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Pseudogenes in Juvenile Nasopharyngeal Angiofibroma: First Pilot Observation.

STUDY DESIGN: Experimental laboratory study. OBJECTIVES: The primary purpose was to investigate the independent effects of current amplitude, pulse duration, and current frequency on muscle fatigue during neuromuscular electrical stimulation (NMES). A second purpose was to determine if the ratio of the evoked torque to the activated area could explain muscle fatigue. BACKGROUND: Parameters of NMES have been shown to differently affect the evoked torque and the activated area. The efficacy of NMES is limited by the rapid onset of muscle fatigue. METHODS AND MEASURES: Seven healthy participan…

Evaluation of minimum pinch force while holding in fibromyalgia patients.

OBJECTIVE: This study aimed to investigate the relationship between the minimum pinch force applied during object carrying and physical fatigue in patients with fibromyalgia. For this purpose, the study evaluated the association between the minimum and maximum pinch forces exerted while carrying a weight and both isokinetic muscle strength and the isokinetic fatigue index. METHODS: One hundred eight (54 FMS/54 healthy) women participated. Pinch force was measured with a force sensor, and wrist flexor/extensor strength and fatigue index were evaluated using an isokinetic dynamometer at 180°/s.…

Perceived Executive Functioning Deficits After Diagnosis in Women with Non-Metastatic Breast Cancer Prior to Adjuvant Therapies.

BACKGROUND: Perceived deficits in executive functioning are among the many difficulties that women diagnosed with breast cancer experience. This study assessed the presence of perceived deficits in executive functioning among women with breast cancer prior to systemic treatment and radiation and associations between perceived deficits in executive function and comorbid fatigue, sleep, and mood disturbance. METHOD: Participants were recruited following their breast cancer diagnosis and assessed using the Behavior Rating Inventory of Executive Function for Adults (BRIEF-A), subjective and objec…

[Causes of CO2 retention in patients with chronic obstructive lung disease].

The mechanisms of chronic ventilatory failure in chronic obstructive pulmonary disease are complex. This paper analyses the diverse available information: mechanical factors and gas-exchange, fighter vs. non-fighter, the ventilatory pattern theory and the fatigue threshold theory. Finally we comment on the evidence supporting the new concept that hypercapnia may develop to avoid or prevent fatigue. Indeed, it is very likely that chronic CO2 retention in COPD may develop by mechanical disadvantages of the inspiratory muscles rather than impairment of ventilation-perfusion ratios. This opens a f…

Influence of remote pain on movement control and muscle endurance during repetitive movements.

During fatiguing tasks, people adapt their movement strategies to offset effects of muscle fatigue. Painful stimuli may compete for cognitive resources during this process, impairing fatigue adaptation. This study determined how pain affected movement control and muscle endurance during a repetitive task and how pain catastrophizing moderated these effects. Twenty-two healthy young adults performed timed reaching movements until voluntary exhaustion on two separate days. On 1 day, subjects simultaneously experienced ischemic pain in the contralateral arm. Subjective pain, and effort were recor…

A Sleep Hygiene and Relaxation Intervention for Children With Acute Lymphoblastic Leukemia: A Pilot Randomized Controlled Trial.

BACKGROUND: Sleep disturbance and fatigue are common and distressing pediatric cancer-related outcomes. Sleep hygiene education and relaxation techniques are recommended to improve sleep in healthy children and adult cancer survivors. No studies have tested these interventions to improve sleep and fatigue for children with acute lymphoblastic leukemia (ALL) in the home setting. OBJECTIVES: The aim of this study is to establish the feasibility and acceptability of a sleep hygiene and relaxation intervention to improve sleep and fatigue for children receiving maintenance chemotherapy for ALL. T…

Клинические, функциональные и когнитивные особенности запоздалого склероза.

ВВЕДЕНИЕ: Поздний множественный склероз (LOMS, начало > 50 лет) получает все большее признание и может отличаться от MS (AOMS) для взрослых. ЦЕЛИ: Сопоставление клинических, моторных и когнитивных характеристик LOMS и LOMS. Исследуйте влияние усталости и депрессии на когнитивное расстройство. МЕТОДЫ: В рамках данного исследования по вопросам контроля 41 пациент ЛОМС и 82 пациента АОМС, страдающие различными заболеваниями, прошли неврологическую экспертизу (включая регистрацию факторов сосудистого риска), нейропсихологическую оценку (включая усталость и депрессию) и оценку моторных функций (9 т

Совпадение в аннотации оригинала
INTRODUCTION: Late-onset multiple sclerosis (LOMS, onset > 50 years) is increasingly recognized and may differ from adult-onset MS (AOMS). OBJECTIVES: To compare clinical, motor, and cognitive features of LOMS vs. AOMS, and explore the influence of fatigue and depression on cognitive impairment. METHODS: In this case-control study, 41 LOMS patients and 82 …

Effects of Acute Carnosine and β-Alanine on Isometric Force and Jumping Performance.

PURPOSE: To assess the effects of acute combined L-carnosine and β-alanine (Carn-BA) supplementation on isometric and dynamic tasks. METHODS: Twelve healthy participants performed knee-extensor maximal voluntary contractions (MVCs) and countermovement jumps (CMJs) before and after a fatiguing protocol (45-s continuous CMJs). Isometric and dynamic tests were performed 4 h after ingestion of Carn-BA (2 g of L-carnosine and 2 g of β-alanine) or placebo (PLA), in random order. After the fatiguing protocol, blood lactate concentration ([La-]), general and muscular rating of perceived exertion (RPE

The association of preoperative nutritional status and physical fitness with postoperative outcomes in esophageal cancer: results from the PReoperative intervention to Improve Outcomes in esophageal cancer patients after Resection study.

PURPOSE: This study aimed to investigate whether preoperative nutritional status and physical fitness after prehabilitation are associated with surgical outcomes, functional capacity, fatigue, and quality of life after esophagectomy. METHODS: This multicenter, observational cohort study included patients with esophageal cancer who underwent curative treatment and multimodal prehabilitation as part of standard care. Preoperative assessments included body mass index (BMI), risk of malnutrition, exercise capacity, handgrip strength (HGS), upper leg muscle function, physical activity level, and f…

Прогнозирующее воздействие симптомов, сообщенных пациентом в множестве миеломы.

Результаты, о которых сообщается в " AbstractPatient " (PROs), связаны с результатами лечения в множестве миеломы (ММ) при клинических испытаниях. Однако большинство инструментов ПРО занимает много времени, что затрудняет их использование в повседневной практике. Наше учреждение включило в себя "Скриншот с гематологическими симптомами пациента" (HPRSS), a. 3-item - вопросник по усталости, боли и качеству жизни (КОЛ). Основная цель этого исследования заключалась в оценке воздействия этих симптомов на выживаемость без прогрессирования (ПФС) и общее выживание (ОС) в реальной группе паци

Совпадение в аннотации оригинала
AbstractPatient-reported outcomes (PROs) are associated with treatment outcomes in multiple myeloma (MM) in the clinical trial setting. However, most PRO tools are time consuming, which hinders use in routine practice. Our institution incorporated a "Hematology Patient-Reported Symptom Screen" (HPRSS), a 3-item questionnaire for fatigue, pain, and quality of…

Health-related quality of life outcomes with nipocalimab versus placebo in generalized myasthenia gravis: an analysis of the Vivacity-MG3 study.

BACKGROUND: Generalized myasthenia gravis (gMG) is an autoimmune disorder that is marked by fluctuating muscle weakness and poor health-rela … C) for 24 weeks. The Myasthenia Gravis-Quality-of-Life 15-item revised scale (MG-QoL15r), Neuro-QoL Fatigue, EQ-5D-5L, Patient Global Impression (PGI) of Severity-Fatigue (PGI-S), and PGI-Change Fatigue (PGI-C) were used to measure patient-reported HRQoL. RESULTS: Nipocalimab + SOC improved MG-QoL15r scores versus placebo + SOC (Least square (LS) mean ch …

Relative Importance of Disease-Modifying Antirheumatic Drug Attributes for Patients with Rheumatoid Arthritis.

PURPOSE: The significance of fatigue reduction in rheumatoid arthritis (RA) is well recognized. However, prior patient preference studies on disease-modifying antirheumatic drugs (DMARDs) have not adequately explored the relative importance of fatigue reduction compared to other DMARD attributes or accounted for preference heterogeneity. The objective of this study is to determine the relative importance of DMARD attributes, including fatigue reduction, from the patient perspective. PATIENTS AND METHODS: We conducted a web-based discrete choice experiment (DCE) survey among RA patients in the…

Profile of cerebrospinal microRNAs in fibromyalgia.

INTRODUCTION: Fibromyalgia (FM) is characterized by chronic pain and reduced pain threshold. The pathophysiology involves disturbed neuroendocrine function, including impaired function of the growth hormone/insulin-like growth factor-1 axis. Recently, microRNAs have been shown to be important regulatory factors in a number of diseases. The aim of this study was to try to identify cerebrospinal microRNAs with expression specific for FM and to determine their correlation to pain and fatigue. METHODS: The genome-wide profile of microRNAs in cerebrospinal fluid was assessed in ten women with FM a…

Comparison of the Pull-Out Strength between a Novel Micro-Dynamic Pedicle Screw and a Traditional Pedicle Screw in Lumbar Spine.

OBJECTIVE: This study aimed to investigate the strength of a novel micro-dynamic pedicle screw by comparing it to the traditional pedicle screw. METHODS: Forty-five lumbar vertebrae received a traditional pedicle screw on one side and a micro-dynamic pedicle screw on the other side as follows (traditional group vs micro-dynamic group): 15 vertebrae underwent instant pull-out testing; 15 vertebrae underwent 5000-cyclic fatigue loading testing; and 15 vertebrae underwent 10,000-cyclic fatigue loading testing and micro-computed tomography (micro-CT) scanning. The peek pull-out force and normaliz…

Reduction in respiratory muscle strength following a series of preparatory and maximal static, dry breath-holds.

Breath-hold diving poses significant physiological challenges to maintaining O2 homeostasis. During a maximal breath-hold, numerous, subsequently augmenting, involuntary respiratory muscle contractions against a closed glottis (i.e., involuntary breathing movements, IBMs) may elicit respiratory muscle fatigue, especially under conditions of arterial hypoxemia. Thus, the purpose of this study was to determine whether respiratory muscle fatigue occurs following a series of static breath-holds in 14 trained male divers. To do so, we measured transdiaphragmatic twitch pressure (PDI,TW), maximal in…

Lower-body compression garments worn following exercise improves perceived recovery but not subsequent performance in basketball athletes.

This study examined the effects of lower-body compression garments on perceived recovery and subsequent performance in basketball athletes. In a parallel-group design, 30 recreational, male basketball athletes were randomly allocated to either a control (CON, n = 15, loose-fitting clothing) or experimental group (COMP, n = 15, compression garments) for 15 h following fatigue-inducing, basketball-specific exercise in the evening (1600-1800 h). Perceptual measures of fatigue and muscle soreness, as well as physical performance tests (sprints, jumps and agility), were performed pre-exercise, post…

[Mental health in software engineers. I. Frequency of mental complaints, physical complaints and psychiatric disorders].

This study examined the physical complaints, mental complaints and psychiatric disorders in software engineers. Subjects were 101 male software engineers. They were evaluated by a semistructured interview. Psychiatric diagnosis was based on DSM-III (Diagnostic and Statistical Manual of Mental Disorders, third edition). The results are summarized as follows: 1) Physical complaints were observed in 68% of the subjects with 25% of the subjects complaining of physical ill-health. This study showed that 12% of the subjects had hypertension, 12%, gastritis or gastro-duodenal ulcer, 14%, allergic dis

Субъективная когнитивная жирность связана с более серьезной физической инвалидностью, о которой сообщают пациенты, при множественном склерозе.

Усталость широко распространена во множестве склерозов (МС) и способствует инвалидности и функциональному снижению. Хотя связи между физической усталостью и инвалидностью хорошо описаны, то, как субъективная когнитивная усталость и жирность соотносятся с инвалидностью в РС, по-прежнему недостаточно изучены. МЕТОДЫ: Люди с MS (PwMS; N = 100) завершили самоотчетные мероприятия по выявлению вторичных заболеваний (например, настроение, сон, субъективная когнитивная усталость и жирность). Отличительной переменной является саморегистрируемое состояние инвалидности (измеряемое с помощью ступеней, свя

Совпадение в аннотации оригинала
BACKGROUND: Fatigue is highly prevalent in multiple sclerosis (MS) and contributes to disability and functional decline. While associations between physical fatigue and disability have been well characterized, how subjective cognitive fatigue and fatigability relates to disability in MS remains understudied. METHODS: People with MS (PwMS; N = 100) completed…

Association of Breast Cancer Symptoms with Patients' Quality of Life and Depression; A Croatian Cross-Sectional Study.

AIM: To find out which symptoms are the most associated with a breast cancer patients' quality of life (QoL) and depression. SUBJECTS AND M … ory II. RESULTS: After the adjustment for other symptoms, sociodemographic and clinical variables, fatigue (β=-0.47, P<0.001), pain (β=-0.24, P=0.023), and appetite loss (β=-0.18, P=0.037) were statistically significantly correlated with QoL. Fatigue was the only symptom significantly associated with depression (β=0.39, P=0.006). CONCLUSION: Fatigue, pa …