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Decrease in hospital admissions for febrile seizures and reports of hypotonic-hyporesponsive episodes presenting to hospital emergency departments since switching to acellular pertussis vaccine in Canada: a report from IMPACT.

OBJECTIVE: Acellular pertussis vaccines were introduced with the promise of an improved safety profile compared with whole-cell vaccines. In … ours after immunization with a pertussis-containing vaccine or 5 to 30 days after immunization with measles-mumps-rubella vaccine. HHE episodes had to occur within 48 hours of receipt of a pertussis-containing vaccine. Poisson regression models were used to compare the average number of monthly admissions for seizures and HHEs before and after introductio …

[Viral agents in patients with infectious processes of the central nervous system].

Local statistics report a great number of cases of neurological diseases of unidentified cause. The purpose of this research was to determin … uelan equine encephalomyelitis (VEE), Herpes simplex (HSV), Epstein Barr (EBV), Dengue, Rubella and Measles virus, through ELISA and indirect immunofluorescence techniques. Of the 54 samples studied, 33 (61.11%) were positive. %). The etiological agents implicated were VEE 14 cases (42.42%); HSV 11 cases (33.33%); EBV 5 cases (15.15%) and Dengue 3 cases ( …

Effect of reminder notices on the timeliness of early childhood immunizations.

OBJECTIVE: To determine whether reminder notices would improve the timeliness of toddler-age vaccinations. DESIGN: Prospective, randomized, controlled trial. POPULATION STUDIED: Two convenience cohorts of 320 children due to receive either measles-mumps-rubella (MMR) vaccine (at 12 months of age) or diphtheria-pertussis-tetanus (DPT)-inactivated polio (IPV)- Haemophilus influenzae type b (Hib) booster vaccine (at 18 months of age). SETTING: Suburban community. INTERVENTIONS: Parents of the identified children were randomly assigned either to a group to receive a reminder notice of pending …

The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis.

We report an extended set of neuroimmunological data detected in cerebrospinal fluid (CSF) from n = 267 patients with definite multiple sclerosis (MS). Known frequencies of oligoclonal IgG (98%), frequencies of intrathecal fractions of IgG, IgA and IgM (72%, 9% and 20%, respectively) were confirmed and quantitated as intrathecal fractions, IgIF or CSF concentrations, IgLOC. Eighty-nine per cent of the patients had a combined 'MRZ-reaction', i.e. intrathecal antibody synthesis (Antibody Index, AI > 1.4) against measles, rubella and/or varicella zoster virus. Frequencies of single antibodies dec…

The relation of early nutrition, infections and socio-economic factors to the development of childhood diabetes.

The relationship of development of diabetes from birth up to 15 years of age to the type of feeding in infancy, childhood infections and vac … he ages of three, six and 12 months or older between patients and unaffected siblings. Histories of measles, chicken pox and whooping cough were equally distributed between the two groups. However, introduction of bottle-feeding was significantly more frequent among unrelated controls at three months of age (9/39 diabetics versus 41/83 controls) and six m …

Epidemiology of encephalitis in children: a 20-year survey.

Four hundred five children from the Helsinki area who were 1 month to 16 years old were treated for acute encephalitis at the Children's Hospital, University of Helsinki, from January 1968 through December 1987. Encephalitis occurred most commonly in children 1 to 1.9 years of age, among whom the incidence was 16.7 per 100,000 child-years. The incidence remained quite high until the age of 10 years, and then gradually declined to 1.0 per 100,000 child-years at the age of 15 years. Since 1983, when mumps, measles, and rubella vaccination eradicated the encephalitides associated with these micro…

Sporadic bovine meningo-encephalitis-isolation of a paramyxovirus.

Isolation of a viral agent (107) directly from brain explants of a 15-month-old heifer with symptoms of a sporadic encephalomyelitis is described. The virus shares properties with the paramyxovirus family. It grows in a variety of cell cultures from different species, and induces nuclear and cytoplasmic inclusion bodies in infected cells. Nucleocapsids measuring 17 nm in diameter were found in the nucleus and cytoplasm of these cells when studied electron microscopically, thus indicating a close relationship of the agent to the measles-distemper-rinderpest group. No infectious virus was releas…

Vaccine Preventable Diseases in the Emergency Department.

Vaccine-preventable diseases (VPDs) are re-emerging worldwide, with declining vaccination coverage since the COVID-19 pandemic resulting in … . The accompanying articles in this issue provide practical perspectives on managing diphtheria and measles in the emergency department, addressing vaccine hesitancy and preparing for VPD-related examination questions.

What's Hot This Year in ID Clinical Science 2025.

The diversity and depth of clinical research in the field of infectious diseases in 2025 were impressive. Multiple new antibiotics were approved, innovative uses of technology to improve patient care were tested, and novel approaches were trialed to address longstanding problems in infectious diseases. Despite this progress, the resurgence of measles in 2025 offers a stark reminder that any progress against infectious diseases can quickly be lost if the principles of infectious diseases and public health are abandoned. Some of the most important clinical trials and trends in infectious disease…

Материнская варицелла: ожидаемая роль врачей первичной медико-санитарной помощи в подтверждении иммунного статуса варицеллы у женщин детородного возраста.

При 19-недельной беременности 32-летняя японская женщина представила 3-дневную историю лихорадки и лезвий на коже и была диагностирована варицелла, которая урегулировалась после антивирусной терапии. В первичной клинике ее иммунитет к краснухе и кори, но не к варицелле, был подтвержден во время предубеждения. Материнская варицелла инфекция может вызывать врожденный синдром варицелы, характеризующийся врожденными порочными формами и неврологическими недостатками. В данном случае все женщины детородного возраста должны оцениваться на предмет их иммунитета от варицеллы до беременности, а врачи, з

Совпадение в аннотации оригинала
At 19-week gestation, a 32-year-old Japanese woman presented with a 3-day history of fever and vesicular rashes on the skin and was diagnosed with varicella, which resolved after antiviral therapy. In the primary clinic, her immunity to rubella and measles, but not to varicella, was confirmed at preconception counseling. Maternal varicella infection can caus…

Pediatric Wells syndrome (eosinophilic cellulitis) after vaccination: A case report and review of the literature.

A 4-year-old boy presented with erythematous vesicular plaques, ulceration, edema, and pruritus on the left foot and ankle 10 days after receiving the tetanus, diphtheria, pertussis, and polio; measles, mumps, rubella, and varicella; and hepatitis A/B vaccines. Biopsy showed eosinophilic infiltrates and flame figures, suggesting Wells syndrome. Patch testing showed a 1+ reaction to neomycin and aluminum hydroxide, with a recall reaction of Wells syndrome of the feet bilaterally. We report a rare case of pediatric Wells syndrome triggered by nonthimerosal vaccine components confirmed by patch t…

Emerging outbreaks associated with conflict and failing healthcare systems in the Middle East.

The escalating conflicts in the Middle East have been associated with the rapid collapse of the existing healthcare systems in affected countries. As millions of refugees flee their countries, they become vulnerable and exposed to communicable diseases that easily grow into epidemic crises. Here, we describe infectious disease epidemics that have been associated with conflicts in the Middle East, including cholera, poliomyelitis, measles, cutaneous leishmaniasis, and diphtheria, that call for appropriate preventive measures. Local ongoing wars and failing healthcare systems have resulted in re…

Vaccine-preventable outbreaks: still with us after all these years.

Outbreaks of vaccine-preventable diseases continue to occur in the United States, and they have been occurring at increasing rates over the past decade. Factors contributing to these outbreaks include importation from abroad, under-vaccination of segments of the population, and incomplete protection or waning immunity with certain vaccines. This article reviews recent outbreaks of measles, mumps, and pertussis in the United States to highlight the extent to which outbreaks of these vaccine-preventable diseases are still occurring and even increasing. Appreciating the magnitude of these illness…

Serological survey of a new type of reovirus in humans in China.

To evaluate the presence of a new type of reovirus (designated R4) in humans, we determined the prevalence of specific antibodies using a neutralization assay and ELISA. The sera from 97 healthy people and 219 patients in our hospital with measles, hand-foot-and-mouth disease, liver diseases, and diarrhoea were investigated. Although the study population was limited, our data suggested that R4 is widespread in the human population. A significantly higher level of R4-specific antibody in patients than in healthy people is worthy of consideration, since it poses a risk for aggravation of the ext…

Anaphylaxis Provoked by Bovine Gelatin Caused by Ingestion of Jelly Candy and Using Hair Gel.

Gelatin, a product obtained by the partial hydrolysis of collagen, is widely used in foods and pharmaceuticals. In the past, most commercially available vaccines, both live and inactivated, contained gelatin as a stabilizer, and allergic reactions to gelatin contained in measles, mumps, and rubella vaccine were reported. However, gelatin-allergy to foods was thought to be rare. It was unknown what factors predisposed recipients to vaccine-related gelatin allergy. There can be a genetic predisposition to gelatin allergy. We report a patient who experienced anaphylactic reaction on ingestion of …

Risk, its perception and the media: the MMR controversy.

This article aims to explore how the media contributes to and generates 'risk' and 'risk perception.' The example of parents refusing to have their children immunised with the measles, mumps and rubella (MMR) vaccine following negative media reporting will be discussed. The media appears to have an important influence on the perception of risk. We are living in a society that is increasingly aware of risk, and in which risk is socially constructed. It is important that healthcare professionals provide clear, consistent, evidence-based information to clients, ensuring that any areas of uncertai…

Update on side effects from common vaccines.

Vaccines have had a tremendous impact on public health by reducing morbidity and mortality from a variety of virulent pathogens. However, unintended side effects continue to pose a potential risk that may outweigh the vaccine's protective attributes. In this review, we discuss recent articles and controversies pertaining to vaccine-associated adverse events. Included in the discussion are influenza, hepatitis B, measles-mumps-rubella, diphtheria-tetanus-pertussis, polio, Haemophilus influenzae type b, and rotavirus vaccines. The importance and contribution of vaccine constituents (such as thim…

Vaccines for persons at high risk due to medical conditions, occupation, environment, or lifestyle, 2003.

The safety and efficacy of current vaccines are reviewed for high-risk populations, such as those with underlying medical conditions or occu … or persons with asthma. Health-care workers are at risk for acquiring and transmitting hepatitis B, measles, and influenza; hence, vaccination against these diseases is recommended.

Transcanal labyrinthectomy in childhood: report of a case.

Vertigo in children is caused by several factors. One such factor is viruses (e.g., mumps, measles, and rubeola) afflicting the inner ear by various mechanisms. In the majority of cases, affected patients improve with clinical therapy and vestibular rehabilitation. We present the case of a child with vertigo as a sequela of mumps virus infection that did not improve with clinical treatment and vestibular rehabilitation. Consequently, the child was submitted to a transcanal labyrinthectomy followed by vestibular rehabilitation, with significant postprocedure improvement of symptoms. We discuss …

Notifications of vaccine preventable diseases in Australia. Quarterly report (January-March 2000).

Vaccine preventable disease notifications for Australia with disease onset dates between January and March 2000 are reviewed. During this quarter, numbers of notifications for Haemophilus influenzae type b disease and measles were the lowest ever recorded, while those for rubella were the lowest recorded since before the epidemic of spring 1992. These are promising trends that are likely to represent a true reduction in disease incidence. Numbers of pertussis notifications declined compared with the last quarter of 1999, but remain high, making up 88% of notifications for the vaccine preventab…