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Effect of timing of surgery on postoperative complications and prognosis in elderly patients with hip fractures.

BACKGROUND: In clinical practice, there is no standardized criteria for the optimal timing of hip fracture surgery in the elderly, and there is much controversy. OBJECTIVES: To investigate the effect of timing of surgery on postoperative complications and prognosis in elderly patients with hip fractures. METHODS: Retrospectively analyzed 636 elderly hip fracture patients over 65 years old. The patients were divided into early group (< 3 days), intermediate group (3-7 days) and late group (> 7 days) according to the time from fracture to surgery, and the three groups were compared with the po…

Prognosis of transphyseal hematogenous osteomyelitis in children: three case reports and a literature review.

BACKGROUND: Transphyseal hematogenous osteomyelitis(THO) has been considered a potential cause of severe sequelae due to its damage to the growth plate. It has been reported that growth disturbance would take place if the area of involvement exceeds 7%. However, the growth plate seems to have more potential to recover and regain normal function. CASE PRESENTATION: We report three cases of hematogenous osteomyelitis(HO) in children (ages 9 weeks, 4 years, and 13 years respectively ) with significant physeal involvement. All patients underwent surgical debridement and antibiotic therapy. Follow

Evaluation of Long-Term Clinical and Radiographic Prognosis of Avulsed Teeth: A Retrospective Study.

BACKGROUND/AIM: Avulsion injuries have an uncertain prognosis. This study aims to evaluate periodontal ligament healing patterns and factors affecting the survival of replanted avulsed teeth. MATERIALS AND METHODS: In this retrospective study, data from 204 avulsed teeth in 143 children (mean age: 9.6 ± 2 years) who sustained avulsion injuries were reviewed. Primary teeth, non-replanted permanent teeth, and cases with follow-up shorter than 60 days were excluded. Data analysis included 60 replanted permanent teeth from 41 patients (18 girls and 23 boys), with a follow-up period ranging from 2…

Prognosis of intentional replantation for periapical periodontitis teeth: a systematic review and meta-analysis.

BACKGROUND: Intentional replantation (IR) includes extraction, subsequent treatment, and replantation of teeth. It is regarded as a final strategy to preserve teeth affected by periapical periodontitis. This review aims to evaluate the overall prognosis and key prognostic factors of IR for periapical periodontitis teeth. METHODS: Ten databases (Ovid MEDLINE, Ovid Embase, etc.) and two registers were searched up to June 2024. Two independent review authors selected and identified prognostic studies (both prospective and retrospective studies) involving patients with periapical periodontitis te…

Development and validation of nomograms for distant metastasis and prognosis of small intestinal neuroendocrine tumors.

BACKGROUND: Small intestinal neuroendocrine tumors (SI-NETs) are difficult to diagnose early and are associated with a poor prognosis due to distant metastasis (DM). This study aims to develop and validate two prediction models to predict risk of DM and prognosis of SI-NETs patients with DM. METHODS: This study included patients diagnosed with SI-NETs from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2021. Univariate and multivariate logistic regression analyses were used to identify independent risk factors for DM. A nomogram was developed using these fact…

[The impact of peritoneal cytology test results on the prognosis of patients with uterine serous carcinoma].

Objective: To explore the impact of peritoneal cytology (PC) test results on prognosis in patients with uterine serous carcinoma (USC). Methods: Medical record information including history of tubal ligation and preoperative hysteroscopy, pathology, surgery, adjuvant therapy, etc. of USC patients admitted to the Cancer Hospital, Chinese Academy of Medical Sciences from January 2004 to December 2020 was retrospectively collected and the cytological sections of PC were reviewed. Positive peritoneal cytology (PPC) patients were classified as PPC group while negative peritoneal cytology (NPC) pati…

Utilization of Machine Learning in the Prediction, Diagnosis, Prognosis, and Management of Chronic Myeloid Leukemia.

Chronic myeloid leukemia is a clonal hematologic disease characterized by the presence of the Philadelphia chromosome and the BCR::ABL1 fusion protein. Integrating different molecular, genetic, clinical, and laboratory data would improve the diagnostic, prognostic, and predictive sensitivity of chronic myeloid leukemia. However, without artificial intelligence support, managing such a vast volume of data would be impossible. Considering the advancements and growth in machine learning throughout the years, several models and algorithms have been proposed for the management of chronic myeloid le

Prognosis of liver abscess in the intensive care unit (POLAIR), a multicentre observational study.

BACKGROUND: Liver abscess (LA) is a rare but potentially serious condition with a high mortality rate. Current epidemiological data of LA patients requiring intensive care unit (ICU) admission are limited. METHODS: This multicentre retrospective study included adults admitted to 24 ICUs in France between January 2010 and December 2020. Risk factors for mortality were identified by multivariate analysis. A propensity score was used to adjust for confounders related to the presence of portal vein thrombosis. RESULTS: 335 patients were enrolled. The median age was 66 years [53-73] and 68% were

Clinical characteristics and prognosis of lichen planus: An experience from a teaching Hospital of Pakistan.

BACKGROUND: Lichen planus (LP) is an inflammatory skin disease, characterized by pruritic, violaceous papules with adnexal involvement in some patients. There is scarce literature about clinical presentations of LP in Pakistan and south Asian region. OBJECTIVE: We aimed to assess the clinical characteristics and prognosis of LP in outpatients of a tertiary-care hospital in Karachi, Pakistan. MATERIALS AND METHODS: A retrospective file review was conducted, from January 2017 to December 2020. Data were retrieved from coded dermatology outpatients' database. All files with clinical and/or hist…

Clinical characteristics and factors associated with recurrence and long-term prognosis in patients with MOGAD.

OBJECTIVE: To describe the clinical features, treatment, and prognostic factors affecting recurrence and long-term adverse outcomes of myelin oligodendrocyte antibody-associated disease (MOGAD). METHODS: In this retrospective cohort study, the records of patients diagnosed with MOGAD at Zhengzhou University First Affiliated Hospital between January 2018 and March 2023 were analyzed, and factors associated with recurrence and poor long-term prognosis were identified using logistic regression. RESULTS: Of the 91 patients, 69 (76%) were new cases, 39 (43%) were female, and 47 (52%) were childre…

The Effect of High-Density Lipoprotein on the Rheumatic Mitral Valve Calcification and Surgical Prognosis.

BACKGROUND: Rheumatic heart disease remains the most common valvular heart disease in Asia and often leads to severe calcification of the valve leaflets. However, the causes of calcification and the factors influencing the prognosis of surgical patients are not yet clearly understood. OBJECTIVES: This study aimed to explore the impact of plasma high-density lipoprotein (HDL) levels on the formation of rheumatic mitral valve calcification and the surgical prognosis. METHODS: This retrospective cohort study included 847 patients who underwent mitral valve surgery for rheumatic heart disease at…

A comparative study of the characteristics and prognosis of orbital myositis versus thyroid-associated orbitopathy.

PURPOSE: To compare the clinical presentation, imaging features and outcomes of patients with orbital myositis (OM) and thyroid associated o … imaging features that distinguish OM from TAO. OM is associated with a better clinical outcome and prognosis with a reduced risk of optic neuritis and relapse compared with TAO patients.

Factors associated with diagnostic delay and prognosis in hospitalized patients with strongyloidiasis in Okinawa, Japan.

BACKGROUND: Prognosis and factors correlated to diagnostic delays in patients with strongyloidiasis, a parasitic disease, remain poorly understood. This study investigated the relationship among diagnostic delay, prognosis, and eosinophilia in patients with strongyloidiasis. METHODOLOGY/PRINCIPAL FINDINGS: Hospitalized patients with a confirmed diagnosis of strongyloidiasis at a single hospital over 10 years (2013-2023) were retrospectively screened. Fifty-five inpatients were included (median age, 81 years); 34 patients (61.8%) were male, and all but one patient was born in Okinawa before 19…

Identification of biomarkers related to the progression of cutaneous melanoma and construction of survival prognosis model.

BACKGROUND: Under certain circumstances, nevi may undergo malignant transformation into skin cutaneous melanoma (SKCM), which is a highly aggressive and deadly malignant tumor originating from melanocytes. Early identification of important genes in the development of nevus into melanoma, timely treatment and blocking of the disease process can effectively reduce the occurrence of melanoma. METHODS: Six datasets were downloaded from Gene Expression Omnibus with the keywords "nevus and melanoma". Differentially expressed genes (DEGs) in nevu vs. normal and melanoma vs. nevus were identified. WG

The prognosis of MG patients with different thymic pathology: a multicenter retrospective cohort study.

BACKGROUND: To identify the associations between thymic pathology and the prognosis of myasthenia gravis (MG) patients. METHODS: In this multicenter retrospective study, 1,254 myasthenia gravis (MG) patients who underwent thymectomy across four clinical centers were included. Participants were categorized by thymic pathology into thymomatous and non-thymomatous groups. Primary outcome was postoperative deterioration. Secondary outcomes comprised the proportion of patients achieving minimal manifestation status (MMS) within the first year after surgery and conversion from ocular MG (OMG) to ge…

Association of HLA-DRB1 pocket structures with susceptibility and prognosis of Graves' and Hashimoto's disease.

The physical and/or electrical properties of the peptide-binding pockets of Human Leukocyte Antigen (HLA) class II molecules vary depending on their amino acid sequence, influencing peptide-binding affinity. Previous studies have reported associations between HLA-DRB1 amino acid polymorphisms and susceptibility to Graves' disease (GD) and Hashimoto's disease (HD). We hypothesized that polymorphisms in the peptide-binding region of HLA-DRB1 contribute to disease development and prognosis. This study investigated associations between HLA-DRB1 amino acid polymorphisms and both the development and…

Impact of Donor CMV-Seropostive Grafts on Prognosis of Liver Transplantation for Hepatocellular Carcinoma.

Studies investigating the impact of donor cytomegalovirus (CMV) positivity on the prognosis of liver transplantation (LT) recipients with HCC are currently lacking. A total of 21 759 eligible LT recipients were identified in the UNOS database between January 2002 and June 2023. The patients were divided into the donor CMV-seronegative (n = 7575) and CMV-seropositive (n = 14 814) groups. Moreover, the subgroup analyses by recipient age and gender were conducted. All patients were also divided into 18-40 (n = 271), 40-60 (n = 9538), and ≥ 60 (n = 11 950) groups, male (n = 16 954) and female (n =…

Impact of HPV detection and p16-Ki67 expression on prognosis in anal cancer patients.

INTRODUCTION: HPV infection has been associated with squamous cell carcinoma of the head and neck, genital tract and anal canal. HPV has two … s, all biomarkers tested negative. DISCUSSION: High- and low-risk HPV genotyping helps predict the prognosis of anal canal lesions. High-risk HPV infection and p16 overexpression are associated with malignant tumoral lesions.

OLR1 is closely related to poor prognosis and immune cell infiltration in gastric cancer.

Oxidized low-density lipoprotein receptor 1 (OLR1) in gastric cancer (GC) progression and immune cell infiltration remains unclear. This study aimed to investigate the impact of OLR1 on GC progression and to elucidate its association with immune cell infiltration in GC. OLR1 expression profiles in GC and paired normal tissues were analyzed using datasets from the TCGA, GTEx, and GEO databases, with validation conducted through quantitative real-time PCR (qPCR) and immunohistochemistry (IHC). Differentially expressed genes (DEGs) associated with OLR1 were identified through gene set enrichment

Роль высокоплотного ЭЭГ в диагностике и прогнозировании неврологических заболеваний: систематический обзор.

ЦЕЛЬ: Использование высокоценной электроэнцефалографии (HD-EEG) расширилось в связи с неврологическими расстройствами благодаря анализу связи мозга. Этот метод позволяет создать детальное картирование мозга. Цель заключается в изучении исследований, в которых используется HD-EEG в неврологической и нейродегенеративной документации. МЕТОДЫ: Этот систематический обзор был проведен и представлен в соответствии с ПРИСМА. Были проведены исследования: 1) слабоумия, 2) множественный склероз (MS), 3) болезнь Паркинсона (PD), 4) инсульт, 5) эпилепсия. Результаты: Исследование включало в себя 89 статей:

Совпадение в аннотации оригинала
OBJECTIVE: The use of High-Density Electroencephalography (HD-EEG) increased in neurological disorders, due to analysis of brain connectivit … SIGNIFICANCE: HD-EEG demonstrated it effectiveness in detection of biomarkers for the diagnosis and prognosis. In dementia contributed to misdiagnosis between different subtype and identifying markers of cognitive decline, investigating motor and cognitive networks dynamics in stroke, PD and MS, and to detect task-specific network reorganization.