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Salient Voice Symptoms in Primary Muscle Tension Dysphonia.

INTRODUCTION: Patients with primary muscle tension dysphonia (pMTD) commonly report symptoms of vocal effort, fatigue, discomfort, odynophonia, and aberrant vocal quality (eg, vocal strain, hoarseness). However, voice symptoms most salient to pMTD have not been identified. Furthermore, how standard vocal fatigue and vocal tract discomfort indices that capture persistent symptoms-like the Vocal Fatigue Index (VFI) and Vocal Tract Discomfort Scale (VTDS)-relate to acute symptoms experienced at the time of the voice evaluation is unclear. Finally, correlations between voice symptoms and acoustic …

Quantifying the burden of hereditary hemorrhagic telangiectasia on quality of life and psychological health: a cross-sectional study.

BACKGROUND: Despite the considerable burden that hereditary hemorrhagic telangiectasia (HHT) imposes, few studies have investigated its effe … rhagic Telangiectasia (NOSE-HHT); Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue - Short Form 8a - Fatigue interfere scale (PROMIS-Fatigue 8a); Hospital Anxiety and Depression Scale (HADS-A and HADS-D); and Short Form Health Survey (SF-36). Statistical analyses included Spearman's correlations, univariate analyses, Tukey's hones …

A comprehensive analysis of the adverse drug events of metastatic and unresectable gastrointestinal stromal tumor treatment options: avapritinib, imatinib, regorafenib, ripretinib, and sunitinib safety insights and implications.

BACKGROUND: Treatments for metastatic, unresectable, or treatment-resistant gastrointestinal stromal tumors (GIST) include avapritinib, imatinib, regorafenib, ripretinib, and sunitinib. The FDA Adverse Event Reporting System (FAERS) database collects medication-related adverse events (AEs). DESIGN AND METHODS: Reports in the FAERS database from each medication's FDA approval to June 30, 2025 were analyzed. Reports containing other medications or indications outside of GIST treatment were excluded. RESULTS: Avapritinib was associated with fatigue (n = 826, 10.2%), nausea/vomiting (n = 574, 7.…

How useful is the expanded disability status scale to neuropsychiatrists?

BACKGROUND: The Expanded Disability Status Scale (EDSS) is a gold-standard disability measure in multiple sclerosis (MS) notwithstanding its … , anxiety and depression (Hospital Anxiety and Depression Scale anxiety and depression sub-scales), fatigue (Modified Fatigue Impact Scale), and self-perception of deficits (Perceived Deficit Questionnaire) was determined with regression analyses (linear or logistic where appropriate). RESULTS: Mean age was 41.79 years (SD=10.27), 75.47% were female, and …

Factors Influencing Quality of Life in Myasthenia Gravis Patients: Results From a Cross-Sectional Study in South of Iran.

BACKGROUND: Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction characterized by fatigue and muscle weakness, often leading to significant impairments in quality of life (QOL). This single-center cross-sectional study investigated factors influencing QOL among MG patients. METHODS: Fifty-two participants diagnosed with MG were assessed using the MG Foundation of America (MGFA) classification and the MG composite (MGC) scale for disease severity. Patients completed validated questionnaires, including the Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), …

Factors influencing employment and absenteeism in working age people with multiple sclerosis.

To examine employment status amongst people with multiple sclerosis (pwMS) in Israel, identify predictors of employment status, and investigate factors contributing to absenteeism amongst employed individuals. This cross-sectional study included 119 pwMS (65 women, mean age, 40.1 years, mean disease duration, 10.0 years). Participants completed self-reported questionnaires assessing employment status, absenteeism, work-related difficulties, perceived fatigue, perceived mobility, bladder and bowel function, fear of falling, and psychological and cognitive factors. The level of disability and in…

Электричество против магнита: Какая стимуляция мозга побеждает за то, чтобы беспокоить симптомы множественного склероза?

Множественный склероз (MS) — хроническое заболевание, характеризующееся усталостью, болью, когнитивным расстройством и расстройством настроения. Фармакологические методы часто оказывают ограниченное облегчение и имеют побочные эффекты, вызывая интерес к неинвазивным методам нейромодуляции, таким, как транскраниальная стимуляция прямого тока (tDCS) и транскраниальная магнитная стимуляция (TMS). Мы стремились сравнить краткосрочную эффективность TDCS и TMS в снижении усталости, боли, депрессии и когнитивных расстройств у пациентов с MS. МЕТОДЫ: В ходе случайного, одноколючего, трёхмерного испыта

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is a chronic disease marked by fatigue, pain, cognitive impairment, and mood disorders. Pharmacological treatments often provide limited relief and have side effects, prompting interest in non-invasive neuromodulation techniques like transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)…

Investigating physical inactivity and associated health parameters in patients with systemic lupus erythematosus.

BACKGROUND: Physical inactivity, which is highly prevalent in patients with systemic lupus erythematosus (SLE), is an independent risk factor for cardiovascular events and causes many complications. This study aimed to investigate the effect of objective measurement and physical activity level on peripheral muscle strength, exercise capacity, pain, dyspnea, fatigue, anxiety, and depression in patients with SLE. METHODS: The present cross-sectional study analyzed 41 patients with SLE. Clinical and demographic characteristics of patients were recorded. Functional exercise capacity, peripheral m…

Relation between Orotracheal Intubation, Inflammatory Markers, Breathing and Voice in Post-COVID-19.

INTRODUCTION: COVID-19, an infectious disease with a wide spectrum of clinical manifestations and intensities in the human body, it can cause respiratory and vocal disorders, with fatigue. OBJECTIVE: To verify the relation between biological Inflammatory markers D-dimers and C-Reactive Protein, Forced Vital Capacity, Maximum Phonation Time, vocal performance and fatigue, length of hospitalization period and gender of people affected by COVID-19 who were hospitalized, but did not use orotracheal intubation and compare with a group of post-COVID-19 patients with orotracheal intubation. METHODS…

Cognitive Difficulties and Health-Related Quality of Life in Sarcoidosis: An Analysis of the GRADS Cohort.

RATIONALE: Subjective cognitive difficulties are common among sarcoidosis patients; however, previous studies have not modeled the link between cognitive difficulties and health-related quality of life (HRQOL). OBJECTIVES: To determine whether cognitive difficulties are associated with HRQOL in sarcoidosis patients after adjusting for demographics, fatigue, and physical disease severity measures. METHODS: We performed a secondary analysis of the Genomic Research in Alpha-1 antitrypsin Deficiency and Sarcoidosis (GRADS) study data. We examined the association between self-reported cognitive d…

Low-energy laser therapy application on knee joints as an auxiliary treatment in patients with polyarticular juvenile idiopathic arthritis: a dual-arm randomized clinical trial.

Patients with juvenile idiopathic arthritis (JIA) always experience persistent pain and stiffness which induces muscle weakness, fatigue, and functional limitations. This study evaluated whether applying low-energy laser therapy (LLT) on the knee joint could be an effective adjuvant intervention for patients with JIA. Sixty children with polyarticular JIA participated and were randomly allocated to receive either LLT (wavelength λ = 903 nm; power output of 50 mW; and energy of 1.5 J) plus exercises (LLT group) or exercises alone (control group). Pain, peak concentric torque of quadriceps muscl…

Anterior cruciate ligament overuse increases collagen fibril compliance: collagen unraveling and elevated glycosaminoglycan activity in a murine model.

Data increasingly indicates that many anterior cruciate ligament (ACL) injuries are likely due to tissue damage accumulation and the gradual decrease in ACL strength and stiffness over time. Previous ex vivo experiments found molecular-level ACL damage (collagen unraveling) to be associated with increased tissue compliance at the collagen fibril-level. However, it remains unclear if this biomechanical effect is present in vivo, or what effect other modulators of tissue mechanics (e.g., glycosaminoglycans (GAGs)) have in fatigued-damaged ACL matrices. Herein, we investigated the in vivo relatio…

Endothelial dysfunction and metabolic biomarkers in post-COVID-19 syndrome.

Acute SARS-CoV-2 infection has been implicated in the development of endothelial dysfunction and metabolic alterations. These disturbances m … CoV-2 infection. Additionally, we explored the association between these biomarkers and PCS-related fatigue severity as assessed by the Multidimensional Fatigue Inventory (MFI). At a median of 37.4 weeks after SARS-CoV-2 infection, participants with prior infection showed higher levels of soluble thrombomodulin (TM) and L-lactate dehydrogenase (LDH) than …

Comparison of diaphragmatic breathing exercises and incentive spirometry on the functional status of heart failure patients: a randomized controlled trial.

BACKGROUND: Respiratory muscle weakness in heart failure (HF) can deteriorate its symptoms such as fatigue, dyspnea, and impaired functional status. Pulmonary rehabilitation can strengthen these muscles. This study aimed to determine the impact of breathing exercises on fatigue severity, dyspnea, and functional classification in HF patients. METHODS: A three-arm single-blind randomized controlled trial was conducted on 90 hospitalized HF patients in three 30-participant groups including diaphragmatic breathing group (DG), incentive spirometry group (SG), and control group (CG). The interventi…

The impact of fibromyalgia syndrome on obstructive sleep apnea syndrome in terms of pain threshold, daytime symptoms, anxiety, depression, disease severity, and sleep quality: a polysomnographic study.

BACKGROUND: Current studies have focused on the association of fibromyalgia syndrome (FMS) and obsctructive sleep apnea syndrome (OSAS). Results of these studies on the effect of this association have been inconsistent. The current study aimed to investigate the effect of FMS on OSAS regarding sleep quality, pressure pain threshold, fatigue, daytime symptoms, anxiety, and depression, and also to determine the relationship between OSAS severity and FMS. METHODS: In a cross-sectional design, patients diagnosed with OSAS were evaluated in two groups comparing those with and those without FMS. Da…

Priorities for alleviating menopausal symptoms after cancer.

OBJECTIVE: To determine treatment priorities in women cancer patients attending a dedicated Menopausal Symptoms After Cancer service. METHODS: Cancer type and stage were abstracted from medical records. Women ranked up to three symptoms as treatment priorities from the list "hot flushes/night sweats," "mood changes," "vaginal dryness or soreness," "sleep disturbances," "feeling tired or worn out (fatigue)," "sexual problems and/or pain with intercourse," "joint pain," and "something else" with free-text response. For each prioritized symptom, patients completed standardized patient-reported o…

Efficacy of high-intensity aerobic exercise on common multiple sclerosis symptoms.

OBJECTIVES: Fatigue and walking impairment are disabling symptoms of multiple sclerosis (MS). We investigated the effects of progressive aerobic exercise (PAE) on fatigue, walking, cardiorespiratory fitness (VO2 max), and quality of life in people with MS (pwMS). MATERIALS & METHODS: Randomized controlled trial (1:1 ratio, stratified by sex) with a 24-week crossover follow-up and intention-to-treat analysis. Allocation to an exercise (24 weeks of PAE followed by self-guided physical activity) and a waitlist (24 weeks of habitual lifestyle followed by PAE) group. PAE comprised two supervised s…

[​Biomechanics of new implants for HTO].

Biomechanical characteristics of 5 tibial osteotomy plates for the treatment of medial knee joint osteoarthritis were examined. Fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy, using TomoFix™ standard, PEEKPower®, ContourLock®, TomoFix™ small stature plates, and iBalance® implants. Static compression load to failure and load-controlled cyclic fatigue failure tests were performed. All plates had sufficient stability up to 2400 N in the static compression load to failure tests. Screw breakage in the iBalance® group and opposite cortex fractures in all…

From sarcopenia to frailty: a road less traveled.

The physical frailty phenotype consists of fatigue, weight loss, and loss of muscle power. Sarcopenia has been shown to be a major cause of frailty. Six societies including SCWD published a consensus suggesting that all persons older than 70 years of age should be screened for frailty when seeing health professionals. Simple screening tests such as the FRAIL (fatigue, resistance, aerobic, illness, and loss of weight) scale can be used. It is felt that frailty can be treated by exercise (resistance and aerobic), high quality protein, vitamin D, and treatment of the common causes of fatigue. It …

Aetiology of skeletal muscle 'cramps' during exercise: a novel hypothesis.

The aetiology of exercise-associated muscle cramps (EAMC), defined as 'painful, spasmodic, involuntary contractions of skeletal muscle durin … e spindle (increased activity) and the Golgi tendon organ (decreased activity) has been observed in fatigued muscle. We hypothesize that EAMC is caused by sustained abnormal spinal reflex activity which appears to be secondary to muscle fatigue. Local muscle fatigue is therefore responsible for increased muscle spindle afferent and decreased Golgi tendon …