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Clinical Efficacy Study of 755 nm Picosecond Laser Combined With 595 nm Pulsed Dye Laser in the Treatment of Port-Wine Stain.

BACKGROUND: Port-wine stain (PWS) is a disfiguring vascular anomaly characterized by persistent cutaneous erythema and progressive tissue hyperplasia. Although pulsed dye laser (PDL) is the first-line treatment and alleviates certain clinical manifestations, incomplete lesion clearance and high recurrence rates persist in some patients, posing significant therapeutic challenges. OBJECTIVE: To evaluate the efficacy and safety of sequential therapy with a 755 nm picosecond laser (PSL) combined with 595 nm PDL versus 595 nm PDL alone in treating PWS. METHODS: Thirty-four patients with PWS were …

Combined radiofrequency electromagnetic and pulsed magnetic field exposure enhances gastric ulcer healing via eNOS-mediated angiogenesis in young rats.

BACKGROUND: This study examined whether combined exposure to radiofrequency electromagnetic field (RF-EMF) and pulsed magnetic field (PMF)s confers gastroprotective and pro-healing effects in an acute ethanol-induced gastric ulcer model by modulating inflammatory, apoptotic, and regenerative pathways. METHODS: Thirty-two female Wistar albino rats were allocated into four groups (Control, RF-EMF+PMF, Ulcer, Ulcer+RF-EMF+PMF; n = 8 each). Gastric ulcers were induced by oral ethanol administration (0.5 ml/100 g). Our innovative exposure combination of 30-min active/90-min passive cycles of 27.12…

Lesion characteristics after pulsed-field ablation in patients with paroxysmal atrial fibrillation and a left common ostium (PFALCO RE-MAP STUDY).

BACKGROUND: Approximately one-fifth of patients undergoing pulmonary vein isolation have a left common ostium (LCO). These patients tend to have worse arrhythmia-free survival when treated with a single-shot device, which may be related to lesion location and ablation thermodynamics. PURPOSE: This study evaluates lesion characteristics around the LCO in paroxysmal atrial fibrillation (AF) patients treated with a pentaspline pulsed-field ablation (PFA) modality. METHODS: Twenty-two patients underwent PFA. Directly after the PFA applications, an electro-anatomical map (EAM) was created using t…

Termination of Longstanding Persistent Atrial Fibrillation Using a Novel Large Focal Lattice-Tip Pulsed Field Ablation Catheter: A Case Report.

Catheter ablation in longstanding persistent atrial fibrillation (AF) presents unique challenges, particularly in patients with large left atria and prior atrioventricular nodal dysfunction. While novel pulsed-field ablation (PFA) has been shown to be safer, no data yet show that a large focal lattice-tip catheter may be more effective. We present a 66-year-old man with symptomatic, longstanding, persistent AF and underlying sick sinus syndrome who underwent catheter ablation using Affera 3D mapping (Medtronic, Minneapolis, MN) and the Sphere 9 catheter (Medtronic, Inc, Mounds View, MN) to pro…

Construction of a nomogram for anxiety and depression in patients with Sjögren's syndrome by combining tongue and pulse characteristics: a cross-sectional study based on a prospective cohort.

OBJECTIVE: To develop and validate a predictive model for predicting psychological complications of Sjögren's syndrome (SS) in combination with tongue and pulse characteristics. METHODS: This cross-sectional study was based on a prospective cohort study including SS patients recruited from 30 major tertiary hospitals in China. Nomograms were developed based on the clinical characteristics, tongue and pulse manifestations, and laboratory tests of these patients, and univariate and multivariate logistic regression analyses were used to screen for various correlates of anxiety and depression, an…

Ultrasound-Guided Peripheral Nerve Pulsed Radiofrequency Combined With Platelet-Rich Plasma Injection for Complex Regional Pain Syndrome：Report of One Case.

Complex regional pain syndrome is a refractory disease characterized by complex pathogenesis，severe chronic pain，and autonomic nervous syste … oral pharmacotherapy for neuropathic pain proved ineffective，she was treated with ultrasound-guided pulsed radiofrequency of the medial plantar nerve combined with platelet-rich plasma injection.Postoperative follow-up showed progressive symptom alleviation.One month after the procedure，the pain score decreased to 0，and autonomic symptoms such as local …

Comparative Efficacy of 595-nm Pulsed Dye Laser versus CO2 Fractional Laser in the Treatment of Scars Following Cleft Lip Repair.

BACKGROUND: The development of scars presents a common clinical concern in the management of cleft lip patients. Both 595-nm pulsed dye laser (PDL) and CO2 fractional laser are effective treatment options; however, comparative studies between these two modalities are lacking. This study is to evaluate and compare the clinical efficacy of 595-nm PDL versus CO2 fractional laser in the treatment of post-cleft lip scars. METHODS: A total of 34 patients with postoperative cleft lip scars were enrolled between May 2023 and July 2025. Participants were randomly assigned to receive either 595-nm PDL …

Результаты однократной и повторной высокочастотной радиочастотной связи для герпеса-зостера у пациентов с диабетом: ретроспективное исследование.

Пациенты с герпесом зостерной нейронгией (HZN) и коморбидным сахарным диабетом (DM) часто испытывают постоянную боль, которая заметно подрывает качество жизни. Большинство из этих пациентов плохо реагируют на пероральные антиконвульсанты или обычные пульсированные радиочастоты (ПРФ). Неоднократное применение высоковольтных РРР может дать более высокие клинические преимущества и повысить степень удовлетворенности пациентов. ЦЕЛЬ: Это ретроспективное исследование было нацелено на анализ результатов одноразового и многократного высоковольтного PRF для грудной клетки HZN у пациентов с ДМ.ПАТИЕНТЫ

Совпадение в аннотации оригинала
BACKGROUND: Patients with herpes zoster neuralgia (HZN) and comorbid diabetes mellitus (DM) often experience persistent pain that markedly undermines quality of life. Most of these patients respond poorly to oral anticonvulsants or conventional pulsed radiofrequency (PRF). Repeated application of high-voltage PRF may offer superior clinical benefits and impr…

Growth differentiation factor 15 level changes in the early and late periods after radiofrequency and pulsed field catheter ablation of atrial fibrillation.

INTRODUCTION: GDF-15 (growth differentiation factor 15) is a protein from the transforming growth factor β (TGF-β) cytokine family. In patients with atrial fibrillation (AF), it is a potent marker of bleeding adverse events in anticoagulated patients and a predictor of overall mortality. However, its level is affected by various conditions, including radiofrequency catheter ablation (RFCA). The study aimed to describe the dynamics of GDF-15 following a novel AF treatment approach, pulsed field ablation (PFA). METHODS: This prospective observational study enrolled 50 patients [median (IQR) age…

Clinical Factors Predicting Favorable Response to Intense Pulsed Light Therapy for Refractory Meibomian Gland Dysfunction: A 6-Month Cohort Study.

PURPOSE: Meibomian gland dysfunction (MGD) is a global health disorder, which can have a deleterious effect on visual function and quality of life. Intense pulsed light (IPL) therapy has been shown to ameliorate MGD. However, the optimal candidates who would benefit most from IPL remain undetermined. Therefore, we aimed in this study to identify the clinical factors associated with favorable outcomes in patients with MGD after IPL therapy. METHODS: This single-center retrospective study included patients with refractory MGD treated with a course of IPL therapy combined with meibomian gland ex…

Feasibility and Safety of Pulsed Field Ablation for Coronary Sinus and Left Atrial Appendage Isolation and Mitral Isthmus Ablation: Acute and Chronic Findings.

BACKGROUND: The safety and efficacy of pulsed field ablation for pulmonary vein and posterior wall isolation in atrial fibrillation ablation are well established; however, evidence regarding its use in extra-pulmonary vein areas remains limited. The aim of this study was to assess the feasibility and durability of pulsed field ablation for coronary sinus (CS) and left atrial appendage (LAA) isolation and mitral isthmus (MI) ablation. METHODS: We analyzed data from consecutive patients who underwent repeat atrial fibrillation ablation with pulsed field ablation between February and October 202…

Preoperative Diquafosol vs. Intense Pulsed Light with Gland Expression for MGD: Effects on Refractive Accuracy and Tear Film Stability in Cataract Surgery.

Objectives: To compare the effects of two preoperative dry eye treatments-3% diquafosol sodium (DQS) and intense pulsed light with meibomian gland expression (IPL-MGX)-on refractive accuracy in cataract surgery and identify tear break-up time (TBUT) thresholds predictive of refractive success. Methods: In this prospective, paired-eye study, 62 patients (124 eyes) with meibomian gland dysfunction underwent bilateral cataract surgery with the same trifocal intraocular lens. One eye received DQS, while the fellow eye underwent four IPL-MGX sessions before biometry. Postoperative absolute predicti…

Differential inflammatory and myocardial biomarker response after pulsed field ablation for atrial fibrillation using balloon-in-basket vs pentaspline catheters.

BACKGROUND: Pulsed field ablation (PFA) is a nonthermal technique for pulmonary vein isolation (PVI) in atrial fibrillation, offering lesion selectivity with minimal collateral damage. Despite its nonthermal nature, systemic inflammatory and myocardial responses may occur. Catheter design could modulate these effects. OBJECTIVE: The purpose of this study was to compare inflammatory and myocardial biomarker responses after PFA using balloon-in-basket vs pentaspline catheter systems. METHODS: This prospective, nonrandomized, single-center study involved venous blood sampling before and the mor…

The Comparable Efficacy Between Tranexamic Acid Intradermal Injection and Pulsed Dye Laser for Treatment of Post-Acne Erythema: A Split-Face Therapy.

Post-acne erythema (PAE) is persistent erythema after acne vulgaris (AV) inflammatory lesions have resolved. Pulsed dye laser (PDL) is the gold standard for vascular lesions and is effective for PAE. Tranexamic acid (TA) can reduce vascular endothelial growth, angiogenesis, and inflammation by inhibiting plasminogen activity, and can be used in PAE treatment. This case report aim to compare the clinical efficacy of intradermal TA and PDL therapy using a split-face design in a 23-year-old female with moderate AV, post-inflammatory hyperpigmentation (PIH), and PEA. Dermatological examination rev…

Impact of Pulsing a Radio Frequency Glow Discharge Lamp on Emission Yields and Analytical Figures of Merit in Glow Discharge Optical Emission Spectroscopy.

The impact of pulsing a radio frequency (RF) glow discharge lamp on analytical aspects in glow discharge optical emission spectrometry (GD-OES) was investigated. The experiments were done with a LECO GDS950 spectrometer. This instrument has a fixed pulse frequency of 320  Hz and adjustable pulse duty cycles (PDC) 100%-6.4%. In the first part, emission yields (EY) were studied by measuring coated steel samples in compositional depth profiling (CDP) mode. Variations in EY were measured by integrating the intensity of emission lines from several elements through the entire coatings at several PDC…

Pulsed Electromagnetic Field Promotes Doxorubicin-induced Apoptosis by Increasing Caspase-2 Activation in MDA-MB-231 Breast Cancer Cells.

BACKGROUND/AIM: Doxorubicin (DOX) is an effective chemotherapeutic drug for breast cancer. Pulsed electromagnetic field (PEMF) stimulation improves the efficacy of chemotherapeutic agents. However, whether PEMF stimulation modulates DOX-induced caspase-2-dependent apoptosis remains unclear. Thus, this study investigated the effect of PEMF exposure on DOX-induced apoptosis in MDA-MB-231 breast cancer cells. MATERIALS AND METHODS: MDA-MB-231 cells were seeded, and the growth medium was replaced with DOX-containing medium and was either unstimulated or stimulated with 1 h PEMF sessions thrice a …

Development of a multiresidue quantitative screening method based on pulsed amperometric detection at a glassy carbon electrode for sulfonamides monitoring in foodstuffs of animal origin.

A new effective quantitative screening method was developed to detect sulfonamides (SAs) in foodstuffs of animal origin. The method was based on pulsed amperometric detection (PAD) at a glassy carbon electrode (GCE) coupled with a reversed-phase high performance liquid chromatographic separation (RP-HPLC). First, SAs electrochemical behaviour at GCE was investigated by cyclic voltammetry (CV) experiments. In the light of the CV results, a new three-step waveform for pulsed amperometric detection of SAs was designed and optimized by performing flow injection analysis (FIA) of SAs standard solut…

Molecular mechanisms of lung injury from ultra high and conventional dose rate pulsed radiation based on 4D DIA proteomics study.

To investigate the mechanism of ultra-high dose rate pulsed radiation in radiation-induced lung injury (RILI), providing an experimental and theoretical basis for the application of FLASH-RT (FLASH-radiotherapy) in radiotherapy. C57BL/6J mice were randomly divided into three groups: a sham group, a FLASH-irradiated group, and a CONV-irradiated group. A whole-body irradiation with a single dose of 3 Gy (200 Gy/s for FLASH group and 0.3 Gy/s for CONV group) using electron rays was used to establish models of lung injury. After 3 months, lung tissues were stained with HE and Masson stains to obse…

Haemolysis and myocardial and neural injury after monopolar pulsed field ablation using a novel lattice-tip catheter to treat atrial fibrillation.

AIMS: The aim of this study was to assess the risk of haemolysis and the extent of myocardial and neural injury after monopolar, monophasic pulsed field ablation (PFA) using a lattice-tip catheter in comparison to single-shot PF ablation platforms employing bipolar, biphasic waveforms. METHODS AND RESULTS: This prospective study included consecutive patients undergoing PFA for atrial fibrillation (AF) using the Affera™ mapping and ablation system (n = 40). Biomarkers for haemolysis (haptoglobin, lactate dehydrogenase, bilirubin), myocardial injury [high-sensitive troponin T, creatine kinase (…