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Cross-Sectional Study of the PREValence of Erectile DysfunctIon in the Arteriopathic Population (PREVEDI).

BACKGROUND: Although the association between erectile dysfunction (ED) and cardiovascular disease is well established, its prevalence in patients with atherosclerosis remains poorly defined. OBJECTIVES: To evaluate ED prevalence, severity, and associated risk factors (RFs) in patients with atherosclerotic disease. MATERIALS AND METHODS: This single-centre, cross-sectional, non-randomised observational study included male patients referred to a vascular surgery service with documented atherosclerotic disease. Erectile function was assessed using the International Index of Erectile Function-15…

The therapeutic effect and mechanism of low-intensity pulsed ultrasound for erectile dysfunction.

As an emerging therapeutic option for erectile dysfunction (ED), low-intensity pulsed ultrasound (LIPUS) has attracted increasing attention. The therapeutic effect of LIPUS is comparable to low-intensity extracorporeal shockwave therapy. However, the underlying mechanism of LIPUS remains unclear. We summarized the current literature to assess the efficacy of LIPUS for ED and elucidate the biological effects caused by LIPUS in different ED models. Preliminary clinical studies demonstrate that LIPUS is beneficial for ED with varying degrees of severity, and its therapeutic effect can be enhanced…

Erectile dysfunction as an early biomarker of cardiovascular toxicity: Mechanisms and clinical implications.

Erectile dysfunction (ED) has been traditionally regarded as a quality-of-life disorder; however, accumulating evidence positions it as an early and clinically actionable biomarker of cardiovascular toxicity. ED and cardiovascular disease share fundamental pathophysiological mechanisms including endothelial dysfunction, reduced nitric oxide bioavailability, oxidative stress, systemic inflammation, autonomic imbalance, and vascular smooth muscle dysfunction. Because penile cavernosal arteries (~1-2 mm diameter) are substantially smaller than coronary arteries (~3-4 mm), the penile vascular bed …

Electrical stimulation for erectile dysfunction: a systematic review and meta-analysis of RCTs.

Recent studies have explored peripheral electrical stimulation (pES) as a potential treatment for erectile dysfunction (ED). This systematic review and meta-analysis evaluate the efficacy of pES in ED patients. A systematic search was conducted across PubMed, Scopus, ScienceDirect, and Web of Science to identify randomized controlled trials (RCTs) published between 2015 and 2025. Studies comparing pES to sham procedures, standard therapies, or no treatment were included. Eligible studies assessed objective or subjective erectile function outcomes, primarily using the International Index of Ere…

Enhancing penile function: the impact of a regenerative multimodal protocol on erectile dysfunction.

BACKGROUND: Erectile dysfunction (ED) is a prevalent condition impacting men's quality of life and is often linked to cardiovascular and metabolic disorders. Conventional treatments like phosphodiesterase type 5 (PDE5) inhibitors could be ineffective for severe cases, indicating a need for innovative approaches. This study aimed to evaluate the efficacy and safety of a multimodal protocol combining low-intensity shockwave therapy (LiST), intrapenile and intravenous umbilical cord-mesenchymal stem cell (UC-MSCs) therapy, and hyperbaric oxygen therapy (HBOT) in men with ED. A retrospective pragm…

A narrative review of endovascular treatment in addressing arterial and venous erectile dysfunction.

Erectile dysfunction (ED) is a worldwide health concern and clinical condition for men, leading to high medical costs and imposing significant emotional and psychological burdens on sufferers annually. ED is associated with multiple causes, including psychological factors and organic issues such as arterial insufficiency and venous leakage. Endovascular treatments have emerged as promising options for managing ED, offering minimally invasive procedures that can improve blood flow to the penis and restore erectile function. Different endovascular interventional approaches have been implemented …

Изучение взаимосвязи между множественным склерозом и эректильной дисфункцией: механизмы и стратегии управления.

Эректильная дисфункция (ЭД) часто встречается у мужчин с множественным склерозом (МС) и возникает из конвергентных нейрогенных, автономических, сосудистых, подстрекательских и психосоциальных путей. Мы синтезируем данные о распространенности эпидемологии и рисках на ЭД в MS, картируем механистические пути связи между центральными и позвоночными повреждениями, автономным-эндетельным дисбалансом и психосоциальными модуляторами и Фенотипами ЭД, а также предоставляем алгоритм поэтапного ухода, интегрирующий нейро-урологические испытания и психо-сексологическую поддержку. В ходе более чем 30 исслед

Совпадение в аннотации оригинала
Erectile dysfunction (ED) is common in men with multiple sclerosis (MS) and arises from convergent neurogenic, autonomic, vascular, inflammatory, and psychosocial pathways. We synthesize epidemiologic prevalence and risk data on ED in MS, map mechanistic pathways linking central and spinal lesions, autonomic-endothelial imbalance, and psychosocial modulators…

The value of audiovisual sexual stimulation with virtual reality in diagnosing erectile dysfunction.

BACKGROUND: The traditional audiovisual sexual stimulation (AVSS) test may experience limitations including low erectile response rate and lack of unified diagnostic criteria. AIM: We aimed to explore the clinical value of AVSS with virtual reality (VR-AVSS) test in assessing erectile function and diagnosing erectile dysfunction (ED). METHODS: Participants 18 to 60 years of age were screened for analysis in 3 clinical centers from June 2020 to March 2022. Demographic data, 5-item International Index of Erectile Function (IIEF-5), erectile hardness score (EHS), and self-reported symptom quest…

A Scoping Review: Is Yoga an Effective Intervention for Erectile Dysfunction and Premature Ejaculation?

There is increasing concern among both healthcare professionals and the general public about the long-term effectiveness and possible adverse effects of medicines used to treat premature ejaculation (PE) and erectile dysfunction (ED). There is also a growing recognition of the advantages of incorporating alternative or traditional approaches into healthcare systems. Yoga is gaining popularity globally and has emerged as a viable adjunct and alternative to add value to patient care and prevention of illnesses, which requires further investigation. This scoping review aimed to explore the effect…

Prevalence and risk factors of erectile dysfunction in cirrhotic patients: An observational study.

BACKGROUND: Erectile dysfunction (ED) is a prevalent complication observed in male patients with liver cirrhosis; however, there is limited understanding of the etiological determinants responsible for its occurrence. The objective of this investigation is to explore potential contributory factors that underlie the development of ED in male patients with liver cirrhosis. METHOD: A cross-sectional study was conducted on 200 male patients with liver cirrhosis, who were divided into three groups according to the Child score. ED was studied using the International Index of Erectile Function (IIEF…

The Effect of Cervical and Lumbar Decompression Surgery for Spinal Stenosis on Erectile Dysfunction.

STUDY DESIGN: Observational study. OBJECTIVES: To evaluate the prevalence of erectile dysfunction and evaluate the effects of decompressive surgery on erectile dysfunction in cervical spinal stenosis and lumbar canal stenosis patients. METHODS: This observational, prospective analysis enrolled patients aged 18-80 with cervical spinal stenosis and/or lumbar canal stenosis that underwent respective decompressive surgery. The IIEF-5 questionnaire was administered preoperatively, and at 6- and 12-months postoperatively to assess erectile dysfunction severity. The EPIC database was queried to det…

Erectile dysfunction and reduced libido in a myasthenia gravis patient treated with methotrexate.

Patients with myasthenia gravis treated with methotrexate are usually young and sexually active. Therefore, sexual dysfunction associated with MTX treatment should be considered and specifically searched in them as it can be an under-recognized cause of treatment failure or poor compliance.

The use of combination regenerative therapies for erectile dysfunction: rationale and current status.

Erectile Dysfunction (ED) is defined as the inability to achieve and maintain an erection sufficient for sexual intercourse. Available treatments for ED provide only symptomatic relief, which is for the most part temporary. Regenerative therapies such as Low Intensity Shockwave, Platelet-Rich Plasma, and Stem Cell therapy can potentially provide a "cure" for ED by reversing the underlying pathology of ED rather than just treating the symptoms. Low Intensity Shockwave therapy is the most evidence based at this point and is thought to act by improving penile blood flow, repairing previous nerve …

The role of aripiprazole in improvement of penile erection in schizophrenia patients with erectile dysfunction.

Aim To provide evidence regarding the effectiveness of aripiprazole in improving penile erection with a therapeutic strategy of add-on or switching therapy in patients with schizophrenia. Methods. PubMed, Cochrane, Clinical Key, ProQuest, EBSCOhost, and ScienceDirect were searched for any design study that evaluated aripiprazole only or versus control (placebo or other antipsychotic) for erectile dysfunction in patients with schizophrenia. Three studies were identified and analysed from 295 initial articles. Data were then extracted from the studies and summarized descriptively. Results Two hu…

Psychoda albipennis myiasis as a rare cause of erectile dysfunction: A case report.

Urogenital myiasis occurring with the settlement of fly larvae of the order Diptera is facultative and is rarely encountered in humans. This study presents a case of urogenital myiasis caused by Psychoda albipennis in a 42-year-old male patient. The patient was admitted to our hospital with complaints of groin pain, pollakuria and erectile dysfunction and claimed that he saw motile larvae in his urine. Three larvae were collected from the patient's urine, microscopically examined and identified as fourth-stage larvae of P. albipennis. The patient's complaints ceased after the application of an…

Interventions to Treat Erectile Dysfunction and Premature Ejaculation: An Overview of Systematic Reviews.

INTRODUCTION: Sexual dysfunction in men is common, and optimal treatment is complex. Although several systematic reviews concerning treatmen … and combined therapies (PDE5 inhibitors and psychological intervention) were effective in treating erectile dysfunction. Most pharmacologic therapies were associated with adverse effects. CONCLUSIONS: There is suggestive evidence that pharmacologic interventions or combined therapies are more effective than non-pharmacologic interventions for treating sexual dysfunc …

Erectile Dysfunction is Predictive Symptom for Poor Semen in Newlywed Men in Japan.

INTRODUCTION: As a continuous decline in semen concentration has been reported, the concept of male infertility has gained increased attenti … s clarified that even among men beginning their attempts at pregnancy, semen findings were poor and erectile dysfunction was involved in poor semen quality in one-quarter of the men. Tsujimura A, Hiramatsu I, Nagashima Y, et al. Erectile Dysfunction is Predictive Symptom for Poor Semen in Newlywed Men in Japan. Sex Med 2019;8:21-29.

[Efficacy and safety of regular use of sildenafil in the treatment of penile erectile dysfunction].

OBJECTIVE: To investigate the efficacy and safety of regular oral use of sildenafil in the treatment of ED. METHODS: We randomly divided 334 ED patients into three groups to be treated orally with sildenafil tablets at 50 mg qd (sildenafil regular), sildenafil tablets at 100 mg 30 minutes before intercourse (sildenafil on-demand), and tadalafil tablets at 10 mg qd (tadalafil regular), all for 3 months. Then we recorded the IIEF-5 score and penile erection hardness score (EHS) and adverse reactions and compared them among the three groups of patients. RESULTS: There were no statistically sign

The Prevalence and Treatment of Erectile Dysfunction in Male Solid Organ Transplant Recipients.

INTRODUCTION: Erectile dysfunction (ED) is a prevalent and under-recognized complaint among male solid organ transplant recipients. Most research on this topic has focused on kidney transplant recipients alone. In this review, we integrate current research on ED across all types of solid organ transplant recipients and assess the success of current methods of ED treatment in transplant populations. AIM: To review the current literature addressing the prevalence and treatment of ED in the male solid organ transplant population. METHODS: A literature search was conducted using PubMed to identi…

Hormonal and Psychogenic Risk Factors for Erectile Dysfunction in Men with HTLV-1.

INTRODUCTION: Erectile dysfunction (ED) is associated with neurological damage due to human T-lymphotropic virus 1 (HTLV-1) infection, but hormonal and psychogenic factors also cause ED. AIM: To evaluate the association of psychogenic and hormonal factors with ED in men infected with HTLV-1. METHODS: In this cross-sectional study, we compared total testosterone, follicle stimulating hormone, luteinizing hormone, prolactin, anxiety symptoms, depressive symptoms, and neurologic manifestations in HTLV-1-infected men with or without ED. The International Index of Erectile Function was used to de…