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Transformative Impact of Nanocarrier-Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons.

Advancing therapeutic progress is centered on developing drug delivery systems (DDS) that control therapeutic molecule release, ensuring precise targeting and optimal concentrations. Targeted DDS enhances treatment efficacy and minimizes off-target effects, but struggles with drug degradation. Over the last three decades, nanopharmaceuticals have evolved from laboratory concepts into clinical products, highlighting the profound impact of nanotechnology in medicine. Despite advancements, the effective delivery of therapeutics remains challenging because of biological barriers. Nanocarriers offe

CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers.

CHAC1, an essential regulator of oxidative stress and ferroptosis, is increasingly recognized for its significant roles in these cellular processes and its impact on various human diseases and cancers. This review aims to provide a comprehensive overview of CHAC1's molecular functions, regulatory mechanisms, and effects in different pathological contexts. Specifically, the study objectives are to elucidate the biochemical pathways involving CHAC1, explore its regulatory network, and discuss its implications in disease progression and potential therapeutic strategies. As a γ-glutamyl cyclotrans

A Review of 3D-Printed Medical Devices for Cancer Radiation Therapy.

This review explores the transformative role of three-dimensional (3D) printing in radiation therapy for cancer treatment, emphasizing its potential to deliver patient-specific, cost-effective, and sustainable medical devices. The integration of 3D printing enables rapid fabrication of customized boluses, compensators, immobilization devices, and GRID collimators tailored to individual anatomical and clinical requirements. Comparative analysis reveals that additive manufacturing surpasses conventional machining in design flexibility, lead time reduction, and material efficiency, while offering

Nanomaterials in gene therapy and genome editing: challenges and emerging directions.

Nanomaterials are redefining the landscape of gene and genome editing, yet their translation to clinical reality remains constrained by multiple unresolved challenges. While they provide structural and functional advantages for delivering nucleic acids and CRISPR/Cas systems across biological barriers, their behavior within living systems is often unpredictable, leading to issues such as off-target editing, immune activation, and inconsistent biodistribution. The design of nanocarriers, whether lipid-based, polymeric, inorganic, must therefore balance efficiency with safety, integrating physic

Screening the Active Phytochemicals From Eclipta prostrata and Unraveling Their Molecular Insight Into Human Malignancies.

Current drugs against multiple human malignancies are limited, and developing new treatment strategies is improbable within a short time. So, considering the current situation, phytochemicals could be a viable option for developing chemotherapeutic agents for managing numerous types of malignancies. Therefore, we aimed to locate all phytochemicals of Eclipta prostrata and unravel their chemotherapeutic mechanisms and strategies individually. We defined 25 active compounds based on their anticancer activities after filtering through IMPPAT and literature search, and these compounds have chemoth

Current State of Human Gene Therapy: Approved Products and Vectors.

In the realm of gene therapy, a pivotal moment arrived with Paul Berg's groundbreaking identification of the first recombinant DNA in 1972. This achievement set the stage for future breakthroughs. Conditions once considered undefeatable, like melanoma, pancreatic cancer, and a host of other ailments, are now being addressed at their root cause-the genetic level. Presently, the gene therapy landscape stands adorned with 22 approved in vivo and ex vivo products, including IMLYGIC, LUXTURNA, Zolgensma, Spinraza, Patisiran, and many more. In this comprehensive exploration, we delve into a rich ass

PROMIS® Health Organization (PHO) 2021 Conference Abstracts.

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… Academy of Information Technology, Warsaw, Poland. 2 Polish Telemedicine and eHealth Society, Warsaw, Poland. 3 Center of Excellence "TeleOrto" for Telediagnostics and Treatment of Disorders and Injuries of the Locomotor System, Medical University of Warsaw, Warsaw, Poland. 4 Department of Medical Informatics …

49th ESCP virtual symposium on clinical pharmacy 19.10.2021-21.10.2021 Clinical pharmacy, working collaboratively in mental health care.

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UEG Week 2017 Oral Presentations

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… Mori 3 1 Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama/Japan 2 Digestive Disease Center, Showa University Koto-Toyosu Hospital, Tokyo/Japan 3 Graduate School Of Informatics, Nagoya University, Nagoya/Japan Contact E-mail Address: ibusiginjp@gmail.com Introduction … Sahin-Tóth 14 1 Clinic For Internal Medicine I, University Clinic Halle (Saale), Halle (Saale)/Germany 2 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany, Leipzig/Germany 3 Center for Exocrine Disorders, Department of Molecular and Cell Biology …

P-Cunt: Подсчитать на основе стойкости гиперинтенсивность белой материи в МРТ мозга.

гиперинтенсивность белых веществ (WMH) является отличительной чертой цереброваскулярной болезни и множественного склероза. Автоматизированные методы сегментации WMH позволяют проводить количественный анализ путем оценки общей нагрузки на повреждения, пространственного распределения повреждений и числа повреждений (т.е. количества подключенных компонентов после установления пороговых значений), все из которых коррелируются с результатами работы пациента. Хотя эти две первые меры, как правило, можно оценить достаточно точно, число повреждений весьма чувствительно к шуму и ошибкам в сегментации,

Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions.

Companion diagnostics (CDx) plays a pivotal role in precision medicine by enabling personalized treatment plans based on individual biomarker profiles. This approach can enhance therapeutic efficacy in selected indications and may reduce healthcare expenditures. Particularly in oncology, precision targeted therapies targeting pathways such as EGFR, HER2, and programmed death-1/programmed death-ligand 1 have established robust models for biomarker-driven treatment. However, rapid advancements in diagnostic technologies, expanding application scopes, and increasingly complex mechanisms of biomar

Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer's disease.

Alzheimer's disease (AD) represents a continuously advancing neurodegenerative condition distinguished by the unremitting deterioration of cognitive abilities and memory impairment, which significantly hampers daily functioning of life. In the absence of disease modifying treatments, it continues to pose a significant global challenge. Though symptomatic treatment exists, the inherent complexity involved with AD pathogenesis related to Aβ plaques, neurofibrillary tangles, neuroinflammation, oxidative stress, etc. poses a tremendous challenge to developing drugs. With the incidence of AD increa

Program-Abstracts

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2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference.

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Systematic review of the tools and outcomes for the assessment of acute radiation dermatitis severity.

Acute radiation dermatitis (ARD) is a common adverse effect experienced by patients undergoing radiation therapy. Effective assessment tools to accurately measure and manage ARD's impact on patients' quality of life and treatment outcomes is needed. The aim of this study was to evaluate the diverse tools and outcome measures used in the assessment of ARD. A systematic review of MEDLINE®, Embase, and Cochrane was conducted for records 1946-March 2024. A total of 423 studies, including 227 randomized controlled trials (RCTs), were included in the analysis. The review identified 58 distinct tools

Next-Generation Sequencing in Oncology: Genetic Diagnosis, Risk Prediction and Cancer Classification.

Next-generation sequencing (NGS) technology has expanded in the last decades with significant improvements in the reliability, sequencing chemistry, pipeline analyses, data interpretation and costs. Such advances make the use of NGS feasible in clinical practice today. This review describes the recent technological developments in NGS applied to the field of oncology. A number of clinical applications are reviewed, i.e., mutation detection in inherited cancer syndromes based on DNA-sequencing, detection of spliceogenic variants based on RNA-sequencing, DNA-sequencing to identify risk modifiers

The 11th NORDIC NUTRITION CONFERENCE NNC2016.

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Abstract Book for the 3rd European Myeloma Network Meeting

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2018 Ежегодное совещание СНГ: Североамериканская конференция по вопросам неадекватности и регулирования.

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… Tero-Pekka Alastalo 1 , Samuel Myllykangas 1 , Pertteli Salmenpera 1 , Mikko Muona 1 , Massimiliano Gentile 1 , Juha Koskenvuo 1 1 Chief Medical Officer and President, Blueprint Genetics 2 Chief Technology Officer, Blueprint Genetics 3 Molecular Technologies Director, Blueprint Genetics 4 Genetic Informatics …

Proceedings to the 2020 Online Conference of the Particle Therapy Cooperative Group (PTCOG2020Online): 13-14 September 2020Organized by the Particle Therapy Cooperative Group (PTCOG), this special online meeting featured abstracts and programs that enabled the communication and cross fertilization for which PTCOG meetings are known.

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… University Hospital Motol, Proton therapy dept., Prague, Czech Republic : 2 PTC Czech- University Hospital Motol, Radiotherapy, Prague, Czech Republic : 3 PTC Czech, Proton therapy dept., Prague, Czech Republic : 4 3rd Faculty of Medicine- Charles University Prague-, Department of Medical Biophysics and Informatics …