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Depth-resolved vascular profile features for artery-vein classification in OCT and OCT angiography of human retina.

This study is to characterize reflectance profiles of retinal blood vessels in optical coherence tomography (OCT), and to test the potential of using these vascular features to guide artery-vein classification in OCT angiography (OCTA) of the human retina. Depth-resolved OCT reveals unique features of retinal arteries and veins. Retinal arteries show hyper-reflective boundaries at both upper (inner side towards the vitreous) and lower (outer side towards the choroid) walls. In contrast, retinal veins reveal hyper-reflectivity at the upper boundary only. Uniform lumen intensity was observed in

LRG1 Alters Pericyte Phenotype and Compromises Vascular Maturation.

Upregulation of leucine-rich alpha-2-glycoprotein-1 (LRG1) contributes to aberrant neovascularization in many different diseases. In contras … se results reveal that exogeneous LRG1 is sufficient to interfere with the maturation of developing retinal vessels and drive vessel development towards a dysfunctional phenotype. These observations deliver further evidence that LRG1 is an angiopathic factor and highlight the therapeutic potential of blocking LRG1 in diseases characterized by pathogenic angiogene …

Retinal Astrocytes: Key Coordinators of Developmental Angiogenesis and Neurovascular Homeostasis in Health and Disease.

Retinal astrocytes reside mainly in the nerve fiber layer and are central to shaping retinal vessels and maintaining neurovascular balance. Derived from the optic nerve head, they spread across the inner retina to form a meshwork that both supports and instructs the emerging superficial vascular plexus. Immature astrocytes supply vascular endothelial growth factor-A(VEGF-A) to guide endothelial sprouting, while signals from growing vessels promote astrocyte maturation and strengthen the blood-retinal barrier. In disorders such as diabetic retinopathy and neovascular age-related macular degener…

[Ultrasonic aspects of combined hamartoma of the pigment epithelium and retina].

The combined hamartoma of the pigment epithelium and retina is a rare developmental tumor characterized by a plaque of thickened retinal pig … ently reported in association with the combined hamartoma, probably depends on the exudation of the retinal vessels and the traction of the hamartoma on the macula. In addition, the echography allowed us to exclude an extension of the lesion to the choroid and the sclera. The electroretinogram and the electro-oculogram were normal as in such localized lesions of …

TIME-COURSE RETINAL CIRCULATION CHANGES IN EYES WITH CENTRAL RETINAL ARTERY OCCLUSION USING LASER SPECKLE FLOWGRAPHY.

PURPOSE: To evaluate retinal circulation in eyes with central retinal artery occlusion. METHODS: The best-corrected visual acuity (BCVA), fluorescein angiography, and laser speckle flowgraphy values were measured at the first visit in 42 patients with central retinal artery occlusion (42 eyes; mean age, 66.0 ± 14.0 years). Laser speckle flowgraphy was performed at baseline, 1 week, and 1, 3, and 6 months; the difference between the mean blur rate vessel area and mean blur rate tissue area (MV-MT), reflecting the retinal vessel blood flow, was measured. Fluorescein angiography measured the art

Progressive retinal degeneration in transgenic mice with overexpression of endothelin-1 in vascular endothelial cells.

PURPOSE: Endothelin-1 (ET-1), synthesized in vascular endothelial cells, is a potent vasoconstrictor. ET-1-related vascular abnormality has been known to be important in the pathogenesis of glaucoma, especially in normal tension glaucoma. However, the long-term effect of increased vascular ET-1 on the retinal tissue is still unclear. METHODS: The mice with overexpression of ET-1 in vascular endothelial cells (TET-1 mice) were examined with the profile of intraocular pressure (IOP), retinal layer thickness, numbers of retinal ganglion cells (RGCs), and axonal changes associated with blood vess

Marked inhibition of retinal neovascularization in rats following soluble-flt-1 gene transfer.

BACKGROUND: In mouse models of retinopathy of prematurity (ROP) inhibitors of vascular endothelial growth factor (VEGF) functions administer … te inhibition of ischemia-induced retinal neovascularization in rats without affecting pre-existing retinal vessels.

Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa.

PURPOSE: The I307N rhodopsin (Rho) mouse is a light-inducible model of autosomal dominant retinitis pigmentosa (adRP) that may be useful in … etinal detachment contributed to retinal thinning. The RPE remained intact, whereas atrophied major retinal vessels were evident after light damage. CONCLUSIONS: Our time-course analysis of retinal degeneration in the I307N Rho mouse with SD-OCT and other outcome measures should enable the use of the mouse model in preclinical efficacy studies and mechanistic st …

Dialogue between programmed cell death and psoriasis.

Computerized image analysis, including fluorescein angiography, was used to evaluate the retinal, choroidal and optic disk blood flow in 16 patients with normal-tension glaucoma (NTG) and to correlate this measurement with visual fields, retinal vessel width, optic disk pallor and blood pressure (BP). The angle of the ascending slope of the fluorescein dye curve was measured as an index of blood flow from the densitometric and time curves of the fluorescein angiograms in the optic disk, peripapillary choroid, retinal artery and vein for each quadrant. While the ascending slope as well as the r

Neurofibromatosis Type 1 Vasculopathy Presenting as Branch Retinal Vein Occlusion: Case Report and Review of the Literature.

Systemic vascular occlusive disease associated with neurofibromatosis type 1 (NF1) has been reported in the aortic, cerebral, renal, celiac, and mesenteric vessels and is referred to as NF1 vasculopathy. Although retinal vascular involvement in patients with NF1 usually manifests as retinal capillary hemangiomatosis, a few cases of NF1 with retinal vascular occlusive disease have also been described. Here, we report a 2-year-old girl with NF1 who presented with branch retinal vein occlusion and peripheral retinal ischemia secondary to NF1. This case demonstrates that NF1-related retinal occlus

Retinal Structural and Microvascular Alterations in Different Acute Ischemic Stroke Subtypes.

INTRODUCTION: Retinal structural and microvascular damages reflect damage to cerebral microvasculature and neurons. We aimed to investigate neovascular unit abnormalities among patients with large-artery atherosclerosis (LAA) or small-vessel occlusion (SAA) and control subjects. METHODS: Twenty-eight LAA patients, forty-one SAA patients, and sixty-five age- and gender-matched controls were recruited. Based on optical coherence tomography angiography (OCTA), retinal capillary vessel density was assessed in the general and local sectors, and the thickness of individual retinal layer was extract

[Indentation of retinal pigment epithelium in polypoidal choroidal vasculopathy detected by retro-mode (scanning laser ophthalmoscopy)].

PURPOSE: To detect by Retro-mode (RM) imaging the nature and frequency of vascular indentation of the retinal pigment epithelium (RPE) due to polypoidal vessels and vascular networks in polypoidal choroidal vasculopathy (PCV). DESIGN: Retrospective cross-sectional study. PATIENTS AND METHODS: Thirty eyes of 29 Japanese patients with PCV diagnosed by ophthalmoscopy and indocyanine green angiography (IA) were retrospectively analyzed by RM imaging. We evaluated the ratio of detection of polypoidal and network vessels in PCV by RM, the main causes hindering vascular indentation of the RPE, and

Experimental inflammatory serous detachment of the retina.

Rhesus monkey eyes were studied after the development of inflammatory serous retinal detachments following internal carotid artery injection of live, yeast-phase Histoplasma capsulatum organisms. Horseradish peroxidase (HRP) was used as a tracer to examine the inner and outer blood-retinal barriers. The HRP was present in a decreasing gradient from the choroid into the subretinal space and was not found to have leaked from retinal vessels. The source of subretinal fluid in this model of inflammatory serous retinal detachment was leakage from the choroid through a defective outer blood-retinal …

Evaluation of blood flow in the ophthalmic artery and central retinal artery in children with retinopathy of prematurity.

PURPOSE: To evaluate blood flow parameters in the ophthalmic artery and central retinal artery in children with retinopathy of prematurity (ROP). MATERIAL AND METHODS: The study comprised 57 premature children born between 24 and 33 weeks of gestation, with birth weight from 600 g to 1660 g, including 42 preterm children with retinopathy in stage 1, 2, 3 and 3 "plus" and 15 preterm children without retinopathy. Color Doppler ultrasonography (USG-CD) was used to measure in the studied vessels maximal systolic velocity (Vmax), end-diastolic velocity (Vmin) and resistance index (RI). RESULTS: S

Контроль качества в целях обеспечения оптической согласованности в томографии по множественным склерозам: исследование по проверке критериев OSCAR-MP.

ЦЕЛИ: Для оценки судов сетчатки широко используется ангиография оптической совместимости (ОКТА). Цель этого исследования заключалась в оценке влияния качества OCTA, измеряемого на основе ранее введенных критериев OSCAR-MP, на параметры результатов OCTA и надежность результатов повторных испытаний. МЕТОДЫ: В рамках этого перспективного продольного когортного исследования мы провели сетчатку OCTA в исходном режиме и в течение 24 часов на 54 участниках, включая 42 здоровых человека и 12 пациентов с демиелинизирующими заболеваниями CNS. Мы провели проверку надежности параметров конечных результато

Совпадение в аннотации оригинала
OBJECTIVES: Optical coherence tomography angiography (OCTA) is widely used for evaluating retinal vessels. The aim of this study was to assess the influence of OCTA quality, as measured by the previously introduced OSCAR-MP criteria, on OCTA outcome parameters and the reliability of test-retest results. METHODS: In this prospective longitudinal cohort study…

A Multidisciplinary Approach to the Management of Eales Disease: A Case Report and Review of the Literature.

Eales disease manifests as an obliterative periphlebitis affecting the retina; it originates from the periphery and progresses posteriorly. It is characterized by retinal vessel wall inflammation, ischemia, and retinal neovascularization. In this report, we present the case of a 34-year-old male who attended our clinic with a sudden blurring of vision in his right eye. A diagnosis of bilateral retinal vasculitis with vitreal hemorrhage was ascertained in his RE. A dilated ocular fundus examination revealed perivenous sheathing of the peripheral vessels in both eyes. Fluorescein angiography ind

Vessel Caliber in Normal Tension and Primary Open Angle Glaucoma Eyes With Hemifield Damage.

PURPOSE OF THE STUDY: The purpose of the study was to evaluate retinal vessel diameter in age-matched normal tension glaucoma (NTG) and primary open angle glaucoma (POAG) eyes with hemifield involvement. METHODS: Fundus photographs of patients with hemifield defect, good visibility of retinal nerve fiber layer defect, and vessels were compared with 30 controls. One eye of each patient (28 NTG and 30 POAG) was randomly chosen for analysis using Image J software by different clinicians at 2 levels. The structural parameters analyzed included retinal nerve fiber layer defect width, diameter of v

Segmentation and Classification Approaches of Clinically Relevant Curvilinear Structures: A Review.

Detection of curvilinear structures from microscopic images, which help the clinicians to make an unambiguous diagnosis is assuming paramount importance in recent clinical practice. Appearance and size of dermatophytic hyphae, keratitic fungi, corneal and retinal vessels vary widely making their automated detection cumbersome. Automated deep learning methods, endowed with superior self-learning capacity, have superseded the traditional machine learning methods, especially in complex images with challenging background. Automatic feature learning ability using large input data with better genera…

Microvascular impairments detected by optical coherence tomography angiography in multiple sclerosis patients: A systematic review and meta-analysis.

PURPOSE: A systematic review and meta-analysis was conducted to investigate changes in retinal and choroidal microvasculature in patients with multiple sclerosis (MS) using optical coherence tomography angiography (OCTA). METHODS: PubMed and Google Scholar were searched for studies that compared retinal and choroidal microvasculature between MS and healthy controls (HC) with OCTA. MS patients were divided into 2 groups: MS with (MSON) or without optic neuritis (MSNON). RESULTS: Totally, 13 studies including 996 MS eyes and 847 HC eyes were included. Compared with the HC, the vessel density o

Retinal Vascular Plexuses Are Unequally Affected in Canine Inherited Retinal Degenerations.

PURPOSE: To characterize the progression of vascular changes that occur in each retinal plexus, in three canine models of inherited retinal degeneration. METHODS: In this retrospective cohort study, we examined the retinal imaging records of 44 dogs from a research colony that had undergone optical coherence tomography angiography (OCTA) imaging. Animals enrolled included crd2/NPHP5 and xlpra2/RPGR mutant dogs imaged at different stages of photoreceptor loss, as well as RHOT4R/+ dogs after acute light-induced rod degeneration. Also included were normal controls imaged at similar ages. OCT ang