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[Diagnosis and treatment of primary hepatic carcinoid tumor].

OBJECTIVE: To discuss the diagnosis and treatment of primary hepatic carcinoid tumor (PHCT). METHODS: Report one case of huge PHCT treated … 3 cases). Immunohistochemical staining was positive for neuron-specific enolase, chromogranin A and synaptophysin in most cases. Sixteen cases received operation, among which there were 13 removed completely, other 4 cases were treated by transcatheter arterial chemoembolization (TACE). CONCLUSIONS: The definite diagnosis of PHCT depends on pathological and hi …

[Jugulotympanic paraganglioma].

Jugulo-tympanic paraganglioma is the most commonly recognized neoplasia involving the middle ear, arising from chemopressure receptors. Clin … nohistochemical analysis revealed two type of cells: chief cells immunostained for chromogranin and synaptophysin and sustentacular cells immunostained for S-100 protein. Clinical presentation of jugulotympanic paraganglioma, when it isn't associated with evidence of hormone secretion, is referred prevalently to bradyacusia, dizziness, and cranial nerve palsies …

[Repair of peripheral nerve defect by a scroll of amnion derivative compound with cultured autogenous Schwann cell in a rat model].

OBJECTIVE: To test a nerve bridge substitute for peripheral nerve repair by tissue-engineering approach. METHODS: An artificial nerve fabricated with a scroll of amnion derivative (ZQ membrane) and cultured autogenous Schwann cell was sutured to bridge sciatic nerve defect of 2.5 cm in length in rats. The specimens were assessed with tracking study, histology, electrophysiological technique, NF200, and synaptophysin-38 (SYP) immuno histochemical staining 3 months postoperatively. RESULTS: The regenerated nerve sprouted 3 months after the operation. The regenerated nerve fibers were plentiful…

Malignant carcinoid tumor of the common bile duct: report of a case.

Carcinoid tumors of the extrahepatic bile duct are exceedingly rare and account for between 0.1% and 2% of all gastrointestinal carcinoid tu … invaded the adjacent pancreatic tissues. Immunohistochemically, the mass demonstrated chromogranin, synaptophysin, and CD56 positivity. The final pathologic diagnosis was well-differentiated carcinoid tumor of a malignant nature. The patient, who underwent a curative surgical resection, was alive and disease-free at the time of writing.

Peripheral primitive neuroectodermal tumor of the cerebellopontine angle.

Peripheral primitive neuroectodermal tumors are highly malignant small cell neoplasms. A 27-year-old female presented with a 6-month history … ei. Immunohistochemical studies demonstrated positive immunoreactivity for neuron-specific enolase, synaptophysin, chromogranin, vimentin, S-100 protein and p30-32 MIC-2 gene product. The patient was treated with chemotherapy (etoposide, vincristine, adriamycin, ifosfamide and actinomycin D) and radiotherapy. After 65 months of follow-up, the patient presented …

Подклеточная локализация связанных с болезнями прионовых белков в человеческом мозге.

Связанный с болезнями прионный белок (PRP(TSE)) содержит в мозге различные иммунизационные схемы в болезни Креуцфельдта-Якоба, включая синаптические, внеклеточные и связанные с клетками локализации. После разработки соответствующего протокола предварительной обработки в целях улучшения иммунозащиты для PrP(TSE) без повреждения эпитопов других антигенов мы систематически оценивали модели совместной локализации отдельных иммунодепозитов PrP(TSE) с помощью конфокальной лазерной микроскопии, включая оптическое последовательное сечение. Как показывает количественная оценка, наиболее заметная совмес

Совпадение в аннотации оригинала
Disease-associated prion protein (PrP(TSE)) deposits in distinct immunostaining patterns in the brain in Creutzfeldt-Jakob disease, includin … rial sectioning. As shown by quantification, the most prominent co-localization of PrP(TSE) is with synaptophysin, but PrP(TSE) may also co-deposit with connexin-32, a gap junction-related protein. Furthermore, neuronal cell bodies, dendrites, axons, astrocytes, and microglia harbor granular PrP(TSE) deposits. Highly aggregated deposits are focally ubiquitinate …

Immunohistochemical and electron-microscopic identification of neuroendocrine cells in the stomach of uremic rats.

Many disturbances in electrolyte and hormonal balance in the body induced by functional impairment of renal parenchyma may affect the activi … cells, immunohistochemical reactions were performed using specific antibodies against somatostatin, synaptophysin, neuron-specific enolase and anti-calcitonin gene related peptide. The analysis showed an increased number of APUD cells in the stomach of uremic rats compared to control rats, which may be a morphological expression of their hyperfunction in the fu …

[Pathological and immunohistochemical study of pineal parenchymal tumors].

OBJECTIVE: To investigate the histological typing and differentiation as well as clinical manifestation and prognosis in pineal parenchymal tumors (PPTs). METHODS: The histological typing of 21 PPTs were made by using HE staining. Synaptophysin (Syn), neuron special enolase (NSE), neurofilament (NF), neuroblastoma (NB), glial fibrillary acid protein (GFAP), cytokeratin (CK), desmin (Des) were detected in 20 cases with SP immunohistochemical staining methods. Analysis of the clinical data and follow-up were performed. RESULTS: 9 pineocytomas, 4 pineoblastomas, 8 pineal parenchymal tumors of i…

Teratocarcinosarcoma of the paranasal sinuses: a clinicopathologic and immunohistochemical study.

We report four cases of sinonasal teratocarcinosarcoma (SNTCS), a rare malignant tumor that displays combined features of an immature or mal … epithelial membrane antigen, alpha fetoprotein, glial fibrillary acidic protein, chromogranin, and synaptophysin. The tumors were consistently negative for beta human chorionic gonadotrophin, neurofilament protein, and leukocyte common antigen. The entities considered in the differential diagnosis were poorly differentiated carcinomas, sarcomas, and olfactory …

Divergent differentiation in pleomorphic xanthoastrocytoma. Evidence for a neuronal element and possible relationship to ganglion cell tumors.

We report the detection of cytoplasmic immunoreactivity for neuronal/neuroendocrine antigens in a subpopulation of tumor cells within seven pleomorphic xanthoastrocytomas (PXAs). The expression of glial and neuronal polypeptides was examined in routinely prepared surgical resections by immunohistochemistry using well-characterized antibodies that recognize glial fibrillary acidic protein (GFAP), synaptophysin (SYN), and neurofilament triplet polypeptides (NFPs) in microwave-enhanced single- and double-immunolabelling experiments. Each neoplasm contained cells that were immunoreactive for SYN a…

Immunohistochemical and electron microscopic study of subependymal giant cell astrocytoma.

Six cases of subependymal giant cell astrocytoma (SGCA), five associated with tuberous sclerosis (TS), were reviewed by light microscopy, electron microscopy and immunohistochemistry. Histologically, all cases showed features typical of SGCA. GFAP and neurofilament expression were found in all cases. Synaptophysin and myelin basic protein were positive in single different cases. The MIB-1 positive rate was 0% in 4 cases, 3% in a case with recurrence after a partial resection, and 6.4% in another case with a rapid growing tumor. By electron microscope, glial filament was identified in the tumor…

Pleomorphic pineocytoma with extensive neuronal differentiation: report of two cases.

Two pineal parenchymal tumors are presented, arising in a 54-year-old man and a 72-year-old woman; respectively. They showed isomorphic, cellular areas of small cells, often with characteristic pineocytomatous rosettes, and of medium-sized cells, as well as less cellular regions with highly pleomorphic, often ganglioid large cells. Immunohistochemistry disclosed extensive neuronal differentiation. There was intense positivity for neurofilament protein and microtubule-associated protein 2 in the pleomorphic areas and more variable expression in the isomorphic regions. Diffuse synaptophysin posi…

Bronchial carcinoid: a clinical follow-up study of 33 cases.

Thirty-three bronchial carcinoid tumours operated on in a 22-year period are reviewed. They were histologically verified as typical carcinoids with Grimelius' argryophilic staining (25 cases), electron microscopy (6) and immunostaining for synaptophysin (4). Nineteen were endobronchial and 14 peripheral, intraparenchymal tumours. Lymph-node metastases were present at operation in two patients. Two tumours, in patients with Cushing's syndrome, were hormonally active (one secreting ACTH and the other ACTH and calcitonin). There was one case of multiple endocrine neoplasia syndrome, but none of c…

Pulmonary spindle cell carcinoid. Needle aspiration biopsy, histologic and immunohistochemical findings.

Six pulmonary spindle cell carcinoids were reviewed. The patients were asymptomatic women ranging from 56 to 76 years of age. Four cases wer … th vascular, focally hyalinized stroma. Immunoreactivity for chromogranin, neuron-specific enolase, synaptophysin, S-100 protein and Leu-7 was typically present; bombesin, serotonin, insulin and calcitonin were focally present in some cases. No reactivity for adrenocorticotropic hormone, somatostatin, gastrin, vasoactive intestinal polypeptide, pancreatic polyp …

Incidental Grade 2 Appendiceal Neuroendocrine Tumor Presenting as Acute Appendicitis in a Young Adult Male Patient.

Neuroendocrine tumors (NETs) are epithelial neoplasms with neuroendocrine differentiation that can arise throughout the gastrointestinal tra … tive margins and no lymphovascular invasion. Immunohistochemistry was positive for chromogranin and synaptophysin, and the Ki-67 proliferation index was approximately 5%. Given the tumor's small size, complete resection, and absence of high-risk features, no further surgery was performed. The patient was referred to oncology for multidisciplinary follow-up. Thi …

Disease-modifying effect of donepezil on APP/PS1 mice at different stages of Alzheimer's disease.

Despite Alzheimer's disease (AD) representing a significant global health concern, disease-modifying therapeutic options remain elusive. The … ic mice from 8.4 months of age was accompanied by progressive accumulation of Aβ plaques, decreased synaptophysin and vesicular acetylcholine transporter immunoexpression. Donepezil had a disease-modifying effect, slowing the deterioration of all the pathological markers studied when treatment was started in a pre-symptomatic stage of AD. However, in the group …

A Case of Bilateral Carotid Body Tumors.

Sporadic bilateral carotid body tumors are a rare paraganglioma of the head and neck that are often asymptomatic and incidentally found duri … med evidence of paraganglioma with immunohistochemical stains showing neoplastic cells positive for synaptophysin, chromogranin, and S100 without lymph node involvement.

Lymphocytic thyroiditis with an oncocytic alteration in a laboratory beagle.

Histopathological, immunohistochemical, and ultrastructural characteristics of lymphocytic thyroiditis in an untreated four-year-old male be … re positive for thyroglobulin and cytochrome C, and that Type B cells were positive for calcitonin, synaptophysin, and cytochrome C. These results indicate that Type A and B cells stem from follicular and C cells, respectively. Ultrastructural investigation showed that microfollicles and microvilli were evident in the cytoplasm and along the luminal surface of …

Metastatic oncocytic adrenocortical carcinoma of mandible: an extraordinarily rare occurrence.

Adrenocortical carcinoma (ACC) is an uncommon primary cancer in the adrenal gland. Its incidence of showing metastasis in the head and neck … high degree of anaplasia. On immunohistochemical examination, tumor cells were focally positive for synaptophysin, inhibin, vimentin, pancytokeratin (pan-CK), cytokeratin (CK)5/6, CD68, and CK8/18 and immunonegative for CK7, chromogranin, melan-A, S100, SMA, and SATB2. The Ki-67 proliferation index was approximately 20%. To the best of our knowledge, this is th …

[Malignant paraganglioma mimicking multiple myeloma].

We here present a 33-year-old woman who was referred to our hospital with a complaint of back pain and was found to have elevated IgG and hy … the bone marrow with a biopsy revealed the proliferation of abnormal cells with chromogranin A and synaptophysin expression but no expression of hematopoietic and epithelial cell markers. Based on these results together with extra-adrenal lesions, a diagnosis of malignant paraganglioma was made. Malignant paraganglioma is known to frequently cause bone metasta …