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Expression and Clinical Significance of Pim-1 and RON in Lung Cancer Patients with Benign and Malignant Pleural Effusion.

BACKGROUND: This study aimed to investigate the expression differences and diagnostic value of Pim-1 and RON in lung cancer patients with be … oup (p < 0.05). RON expression levels were also significantly elevated in the MPE group (p < 0.01). ROC curve analysis revealed that the areas under the curve (AUC) for diagnosing MPE using pleural effusion Pim-1 and RON were 0.646 (95% CI 0.526 - 0.766) and 0.809 (95% CI 0.715 - 0.904), respectively. The AUC for the combined detection of Pim-1 and RON was …

Serum uric acid as a diagnostic biomarker for preeclampsia: comparison with renal indices and cerebroplacental ratio.

OBJECTIVE: To investigate the diagnostic performance of renal function-related indices (blood urea nitrogen (BUN), serum creatinine (sCr), s … independent predictor of PE, with a substantially increased odds ratio (OR) of 14.082 (P < 0.001). ROC curve analysis revealed that sUA had the highest area under the curve (AUC) for diagnosing PE (AUC = 0.837; 95% CI: 0.775-0.899), with a sensitivity of 75.00% and a specificity of 84.09%. CONCLUSION: Among the multiple renal function indices studied, sUA …

Optimizing surgical indication in patients with borderline resectable pancreatic ductal adenocarcinoma to prevent futile pancreatectomy.

BACKGROUND: Borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC) carries a high risk of early recurrence (ER) despite neoadjuvan … ) and post-NAC CA19-9 levels (149 vs. 27 U/mL; P = 0.002) were significantly higher in ER patients. ROC curve analysis identified a post-NAC CA19-9 cutoff of 100 U/mL (area under the curve, 0.77) predicting ER. Patients with post-NAC CA19-9 ≥100 U/mL had significantly worse progression-free (hazard ratio [HR], 5.84; P < 0.001) and overall survival (HR, 6.36 …

Факторы риска и предсказательная модель для распространения внутриутробной коагуляции у пациентов с множественной миеломой.

Multieloma (MM) — гематологическая халатность, содержащая приблизительно 10% Из всех рака крови. Пациенты с MM подвергаются риску распространения внутриваскулярной коагуляции (DIC), что является серьезным осложнением, характеризующимся системной активацией коагуляции, приводящей к микротромби, дисфункции органов и сильному кровотечению. Цель этого исследования состоит в том, чтобы изучить распространенность ДМО среди пациентов ММ и выявить факторы риска, связанные с развитием ДМО. Мы также стремились разработать формулу прогнозирования для оценки риска ДИС. Ретроспективный анализ был проведен

Совпадение в аннотации оригинала
ObjectivesMultiple myeloma (MM) is a hematologic malignancy comprising approximately 10% of all blood cancers. Patients with MM are at risk … ion analysis included prothrombin time (PT), fibrin degradation products (FDP), and D-dimer levels. ROC curve analysis indicated that the predictive model had strong discriminatory power, with an area under the curve (AUC) of 0.927. A predictive formula for the probability of DIC occurrence was developed based on the logistic regression model.ConclusionsThe …

Early differential diagnosis models of Talaromycosis and Tuberculosis in HIV-negative hosts using clinical data and machine learning.

BACKGROUND: Talaromyces marneffei is an emerging pathogen, and the number of infections in HIV-negative individuals is increasing. In HIV-ne … logistic regression analysis was 0.918 (0.884-0.953). The model was verified in the validation set. ROC curve analysis of the validation set showed that the AUC (95 % CI) was 0.900 (0.841-0.959). CONCLUSION: These new differential diagnosis models can calculate the probability of either talaromycosis or tuberculosis.

Novel Index Combining Pan-Immune-Inflammatory Index and Hemoglobin Levels (PIV/Hb) Predicts Trismus Rates Efficiently after Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer.

PURPOSE: To evaluate the predictive potency of a novel index combining the pan-immune-inflammatory index and hemoglobin levels (PIV/Hb) for … cteristic (ROC) curve analysis. RESULTS: Post-CCRT RIT was diagnosed in 20.2% of the patients. The ROC curve analysis determined 68.4 g/dL as the ideal PIV/Hb cutoff that effectively divided patients into two distinct groups (area under the curve: 94.7%; specificity: 86.4%; sensitivity: 87.4%). RIT was significantly more prevalent in the PIV/Hb > 68 group …

Establishing a prediction model of infection during the intravesical instillation of bladder cancer: a multicenter retrospective study.

Objective: To explore the independent risk factors of infection during the intravesical instillation of bladder cancer and establish a prediction model, which may reduce probability of infection for bladder cancer patients. Material and Methods: 533 patients with newly discovered NMIBC at two hospitals from January 2017 to December 2019 were enrolled in this study. The patients were divided into "infection positive group" and "infection negative group". The clinical data of the two groups were analyzed by logistic regression analyses. Nomogram was generated and ROC curve, calibration curve wer…

Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson's Disease.

INTRODUCTION: Impulse control disorder (ICD) in Parkinson's disease (PD) is a critical nonmotor symptom with personality or neuropsychiatric … ulsive traits (p =0.009) compared with the good-outcome group at the pre-intervention state. In the ROC curve analysis, the Obsessive-Compulsive Inventory showed the highest area under the curve with 80.0% sensitivity and 74.3% specificity in discriminating against the poor-outcome group. CONCLUSIONS: Our results suggest that assessment of obsessive compul …

CircCDYL Serves as a New Biomarker in Mantle Cell Lymphoma and Promotes Cell Proliferation.

INTRODUCTION: Mantle cell lymphoma (MCL) is a rare subtype of B-cell lymphoma. Circular (circ) RNA is a member of the non-coding RNA family. … ect on cell proliferation. RESULTS: CircCDYL was high expressed in the plasma of MCL patients. The ROC curve showed that circCDYL had diagnostic value (area under the curve (AUC) = 0.856). Functionally, circCDYL knockdown inhibited MCL cell proliferation. We conducted bioinformatics analyses and identified a circCDYL-micro (mi)RNA-mRNA/long non-coding (lnc …

Relationship between Activities of Daily Living and Readmission within 90 Days in Hospitalized Elderly Patients with Heart Failure.

AIMS: To examine the relationship between activities of daily living (ADL) and readmission within 90 days and assess the cutoff value of ADL … < 0.01) remained statistically significant. The cutoff value for the motor FIM score determined by ROC curve analysis was 74.5 points (area under the curve = 0.78; p < 0.001). CONCLUSION: The motor FIM score in elderly patients with HF was an independent predictor of rehospitalization within 90 days.

Predictive value of repeated measurements of luteal progesterone and estradiol levels in patients with intrauterine insemination and controlled ovarian stimulation.

OBJECTIVE: The objective of this study is to assess if the difference of repeated measurements of estradiol and progesterone during luteal phase predict the outcome of intrauterine insemination. DESIGN: Prospective study. SETTING: Reproductive clinic. PATIENTS: 126 patients with infertility. INTERVENTION(S): Patients underwent controlled ovarian stimulation with recombinant FSH (50-150 IU/d). The day of IUI patients were given p.o natural micronized progesterone in a dose of 100 mg/tds. RESULTS: The area under the receiver characteristic operating curve (ROC curve) in predicting clinical …

Application of a predictive model of axillary lymph node status in patients with sentinel node metastasis from breast cancer. A retrospective cohort study.

BACKGROUND AND OBJECTIVES: The Axillary Lymph Node Dissection (ALND) is the standard treatment in patients with invasive breast cancer and s … Sensitivity, specificity, positive and negative predictive values and AUC (Area Under Curve) of the ROC curve of the nomogram were then calculated. RESULTS: A cut-off by 50% yielded 92.3% sensitivity, 81,4% specificity, 80% positive predictive value and 92.9% negative predictive value. The ROC curve AUC in these patients was 0.885. CONCLUSIONS: The MSKCC …

Screening for sleep apnoea in mild cognitive impairment: the utility of the multivariable apnoea prediction index.

Purpose. Mild cognitive impairment (MCI) is considered an "at risk" state for dementia and efforts are needed to target modifiable risk fact … pnoea (AHI: r = 0.47, P = 0.017). However, this relationship was not significant in the MCI sample. ROC curve analysis indicated much lower area under the curve (AUC) in the MCI sample compared to the controls across all AHI severity cut-off scores. Conclusions. In older people, the MAPI moderately correlates with AHI severity but only in those who are cogn …

Computer-aided detection of breast cancer on mammograms: a swarm intelligence optimized wavelet neural network approach.

Breast cancer is the second leading cause of cancer death in women. Accurate early detection can effectively reduce the mortality rate cause … e inherent discrimination capacity of the proposed system. The result shows that the area under the ROC curve of the proposed algorithm is 0.96853 with a sensitivity 94.167% of and specificity of 92.105%.

Accuracy of two forms of infrared image analysis of the masticatory muscles in the diagnosis of myogenous temporomandibular disorder.

The aim of the present study was to assess the accuracy of two forms of infrared image analysis (area and extension) of the masseter and ant … the measurement of the area of the left anterior temporalis muscle (p = 0.011). The area under the ROC curve was less than the reference values for all muscles evaluated in the analyses of area and extension. Thus, neither method of infrared thermography tested for the quantification of the masseter and anterior temporalis muscles (analysis of area and ext …

Screening tools for obstructive sleep apnea in patients with systemic lupus erythematosus.

BACKGROUND: Obstructive sleep apnea (OSA) seems to be an important comorbidity in systemic lupus erythematosus (SLE) but studies on prevalen … and NoSAS. The ability of these questionnaries to diagnose apnea in SLE patients was analyzed with ROC curves, determining the area under the ROC curve (AUC-ROC) and the respective 95% confidence intervals. RESULTS: The final sample included 19 SLE patients (women: 89.5%; mean age: 35.6 ± 10.3 years; mean BMI: 27.87 ± 6.87 kg/m2) and 20 controls. The preva …

Minimal clinically important difference in patients who underwent decompression alone for lumbar degenerative disease.

BACKGROUND CONTEXT: The minimal clinically important difference (MCID) represents the smallest change in an outcome measure recognized as cl … hange" method for MCIDs. The MCID values for percentage-change in HRQOLs were also calculated using ROC curve analysis. The three cutoff values for each HRQOL were validated using the Youden index for determining the most robust MCIDs. RESULTS: Of the patients, 356 (84.4%) were at least "somewhat satisfied" with the treatment results. The two cutoff values …

Pulmonary complications in children with hematologic malignancies: accuracy of diagnosis with chest radiography and CT.

PURPOSE: To determine the diagnostic accuracy of chest radiography and computed tomography (CT) in patients with complications during treatment for hematologic malignancies. MATERIALS AND METHODS: CT scans were obtained 1 week or less before bronchoscopic sampling or biopsy in 48 pediatric patients (age range, 8 months to 18 years at diagnosis) undergoing treatment for leukemia, lymphoma, or myeloproliferative disease. Radiographs were obtained less than 1 week before CT. Pulmonary complications comprised fungal (n = 11), viral (n = 4), and bacterial (n = 5) pneumonias; cryptogenic organizing

Tumor length-to-height ratio as a predictor of recurrent laryngeal nerve lymph node metastasis in patients with thoracic esophageal squamous cell carcinoma.

BACKGROUND: The metastasis of laryngeal nerve lymph node is mostly found in the upper-and middle esophageal cancer, the ratio of esophageal … ue was 16.66 for LH with an area under the curve value of 0.69. Compared with the Height (H) and L, ROC curve for LH have better performance in predicting the RLN LN metastasis. CONCLUSIONS: LH is a useful predictive tool in the evaluation of RLN LN metastasis for esophageal cancer. The present findings support the result that LH can be an indicator of RLN …

Detection of malignant pleural mesothelioma in exhaled breath by multicapillary column/ion mobility spectrometry (MCC/IMS).

Malignant pleural mesothelioma (MPM) is predominantly caused by previous asbestos exposure. Diagnosis often happens in advanced stages restricting any therapeutic perspectives. Early stage detection via breath analysis was explored using multicapillary column/ion mobility spectrometry (MCC/IMS) to detect volatile organic compounds (VOCs) in the exhaled breath of MPM patients in comparison to former occupational asbestos-exposed and non-exposed controls. Breath and background samples of 23 MPM patients, 22 asymptomatic former asbestos (AEx) workers and 21 healthy non-asbestos exposed persons we