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Orthokeratology for stable mild-to-moderate keratoconus: a pilot study on safety and corneal remodeling via quantitative OCT analysis.

OBJECTIVE: To assess the efficacy and safety of overnight orthokeratology (Ortho-K) in patients with stable, mild-to-moderate keratoconus an … 18 initially enrolled patients discontinued treatment, primarily due to visual symptoms (nocturnal glare, halos) or tolerance issues (dry eye, handling difficulties). A total of 23 episodes of mild corneal punctate staining were recorded, all of which resolved completely following temporary lens discontinuation and pharmacological treatment, with no se …

Evaluation of visual stress symptoms in age-matched dyslexic, Meares-Irlen syndrome and normal adults.

AIM: To examine the prevalence of dyslexia and Meares-Irlen syndrome (MIS) among female students and determine their level of visual stress … er in the last 2y. About 13% were recommended eye exercises and one participant experienced pattern glare. Hand preference was not associated with any condition but Group 1 subjects (3/9, 33%) were significantly more likely to be diagnosed of lazy eye than Group 2 (2/27, 7%) and control (27/414, 7%) subjects. The mean±SD of TVSS responses were 63±14 and …

Feasibility of bone marrow edema detection using dual-energy cone-beam computed tomography.

BACKGROUND: Dual-energy (DE) detection of bone marrow edema (BME) would be a valuable new diagnostic capability for the emerging orthopedic … rk consisted of (i) projection interpolation onto matched LE and HE projections views, (ii) lag and glare deconvolutions, and (iii) efficient Monte Carlo (MC)-based scatter correction. Virtual non-calcium (VNCa) images for BME detection were then generated by projection-domain decomposition into an Aluminium (Al) and polyethylene basis set (to remove be …

Multifocal versus monofocal intraocular lenses after cataract extraction.

BACKGROUND: Good unaided distance visual acuity is now a realistic expectation following cataract surgery and intraocular lens (IOL) implant … cal IOLs, including effects on visual acuity, subjective visual satisfaction, spectacle dependence, glare and contrast sensitivity, compared to standard monofocal lenses in people undergoing cataract surgery. SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register), The Cochrane Library 2012, Issue 2, MEDL …

"Best Pick and Hold" with "Wrap and Roll" technique for extreme subluxated crystalline lens.

BACKGROUND: A severely subluxated crystalline lens refers to significant displacement of the eye's natural lens from its normal position, often due to zonular weakness or rupture.[1] This condition can result from trauma, connective tissue disorders like Marfan syndrome, or advanced pseudoexfoliation.[2,3] Visual symptoms include blurred vision, monocular diplopia, and glare. On examination, lens edge may be visible within the pupil, and phacodonesis (lens wobbling) may be noted. Severe subluxation increases the risk of complications such as angle-closure glaucoma, lens-induced uveitis, or ret…

[Safety and efficacy of aspheric phakic IOL implantation in myopia: short-term clinical results].

Objective: To evaluate the clinical safety and efficacy of aspheric phakic intraocular lens (PIOL) implantation for myopia correction. Metho … heral vault was observed between groups (both P>0.05). At 1 month postoperatively, the incidence of glare in the experimental group [24.72% (22/89)] was significantly lower than that in the control group [54.26% (51/94)] (P<0.05). And there were no statistically significant differences between the two groups in the incidence of other visual symptoms inc …

Development and Validation of a Preference-Based Glaucoma Utility Instrument Using Discrete Choice Experiment.

IMPORTANCE: A glaucoma-specific instrument for estimating utilities across the spectrum of glaucoma severity is currently lacking, hindering … EXPOSURES: Glau-U comprised 6 quality-of-life attributes: activities of daily living, lighting and glare, movement, eye discomfort, other effects of glaucoma, and social and emotional effects. The descriptions or response options for these attributes were no difficulty or never, some difficulty or sometimes, or severe difficulty or often. MAIN OUTCOME …

Multifocal versus monofocal intraocular lenses after cataract extraction.

BACKGROUND: Good unaided distance visual acuity is now a realistic expectation following cataract surgery and intraocular lens (IOL) implant … cal IOLs, including effects on visual acuity, subjective visual satisfaction, spectacle dependence, glare and contrast sensitivity, compared to standard monofocal lenses in people undergoing cataract surgery. SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2012, Issue 2), MED …

Therapeutic effects and safety of apatinib mesylate on patients with gastric carcinoma peritoneal metastasis in SOX scheme.

OBJECTIVE: The aim of this study was to investigate the diagnostic values of serum tumor markers in gastric carcinoma peritoneal metastasis and the therapeutic efficacy as well as safety of apatinib mesylate combined with Geo+Oxaliplatin (SOX) scheme treatment in gastric carcinoma peritoneal metastasis. PATIENTS AND METHODS: Sixty patients with gastric carcinoma peritoneal metastasis and 11 patients without gastric carcinoma peritoneal metastasis were selected as the research subjects. The levels of serum tumor markers [carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125, CA211, CA2

Comparison of U.S. FDA premarket approval studies between two non-diffractive extended depth of focus lenses (AcrySof IQ Vivity versus TECNIS PureSee).

BACKGROUND: Several recent clinical studies have directly compared TECNIS PureSee with lenses from the Vivity platform; however, direct comp … eyes were unable to detect the mesopic contrast reference pattern at 6 and 12 cpd with and without glare. Visual symptoms and spectacle independence were also reported descriptively because the trials used different questionnaires. Each trial met the safety and performance endpoint limits applicable to its respective ISO 11979-7 edition. CONCLUSIONS: …

Out-of-the-bag intraocular lens dislocation: outcomes of posterior chamber intraocular lens exchange, risk factors, and prevention.

BACKGROUND: Dislocation of posterior chamber intraocular lens is one of the most common complications of intraocular lens implantation. Lens … ents mainly included decrease in visual acuity (17 cases, 47.2%), blurred vision (16 cases, 44.4%), glare (1 case, 2.8%), diplopia (1 case, 2.8%), and halo (1 case, 2.8%). Intraocular lens dislocation into the posterior vitreous cavity (29 eyes, 80.5%), anterior chamber (1 eye, 2.8%) and anterior vitreous cavity (6 eyes, 16.7%) was found in this series. …

Amiodarone-induced ocular and extra-ocular toxicity: a retrospective cohort study.

Amiodarone (AMD) is a largely employed anti-arrhythmic agent for the treatment of recurrent supraventricular and ventricular tachyarrhythmia … rders ranging from blurred vision and deterioration of visual acuity to eye redness and progressive glare were reported in 14 patients and lasting photophobia in the remaining 3 patients. Verticillate keratopathy (VK), stage 1-4, was diagnosed in all of them. Following AMD cessation, the patients were checked after a mean of 94 days and clear corneas we …

Symptoms and Satisfaction of Patients in the Patient-Reported Outcomes With Laser In Situ Keratomileusis (PROWL) Studies.

IMPORTANCE: Patient-reported outcomes should be collected using validated questionnaires prior to and following laser in situ keratomileusis … myopia, hyperopia, and/or astigmatism. MAIN OUTCOMES AND MEASURES: Visual symptoms (double images, glare, halos, and/or starbursts), dry eye symptoms, participant satisfaction (with vision and LASIK surgery), and clinical measures (visual acuity, refractive error, and slitlamp and posterior segment eye examination findings) were assessed preoperatively …

[Comparative clinical study of wavefront-guided laser in situ keratomileusis with versus without iris recognition for myopia or myopic astigmatism].

OBJECTIVE: To explore the postoperative visual acuity results of wavefront-guided LASIK with iris recognition for myopia or myopic astigmati … 004) spatial frequencies of CSF under mesopic condition was better than non-iris recognition group, glare contrast sensitivity function (GCSF) for 3.0 c/d (t = 3.423, P = 0.001) and 6.0 c/d (t = 6.986, P = 0.000) spatial frequencies under mesopic condition and 1.5 c/d (t = 9.839, P = 0.000) and 3.0 c/d (t = 7.367, P = 0.000) spatial frequencies under ph …

Development and Validation of the PaP Score Nomogram for Terminally Ill Cancer Patients.

The validated Palliative Prognostic (PaP) score predicts survival in terminally ill cancer patients, assigning patients to three different risk groups according to a 30-day survival probability: group A, >70%; group B, 30−70%; and group C, <30%. We aimed to develop and validate a PaP nomogram to provide individualized prediction of survival at 15, 30 and 60 days. Three cohorts of consecutive terminally ill cancer patients were used: one (n = 519) for nomogram development and internal validation, and a second (n = 451) and third (n = 549) for external validation. Multivariate analyses included

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… Glare P., Sinclair C., Downing M., Stone P., Maltoni M., Vigano A. Predicting survival in patients with advanced disease. Eur. J. Cancer. 2008;44:1146–1156. doi: 10.1016/j.ejca.2008.02.030. 7. Glare P., Virik K., Jones M., Hudson M., Eychmuller S., Simes J., Christakis N. … Glare P., Virik K. Independent prospective validation of the PaP score in terminally ill patients referred to a hospital-based palliative medicine consultation service. J. Pain Symptom Manag. 2001;22:891–898. doi: 10.1016/S0885-3924(01)00341-4. 24. Glare P.A., Eychmueller S., McMahon P. …

Surgeon practices regarding postoperative thromboembolic prophylaxis after high-risk spinal surgery.

STUDY DESIGN: Survey study. OBJECTIVE: To assess a sample of spine surgeons' current practices of thromboembolic prophylaxis after high-risk surgery for tumors and trauma. SUMMARY OF BACKGROUND DATA: Although chemoprophylaxis for thromboembolic events is not routinely used after elective spinal surgery, it is more widely recommended in high-risk patients after spine surgery for trauma or tumors. In these high-risk cases, surgeons must decide what method(s) of prophylaxis to use and when it can be safely initiated. Unfortunately, there are limited data evaluating the efficacy or safety of dif

N-acetylcarnosine (NAC) drops for age-related cataract.

BACKGROUND: Cataract is the leading cause of world blindness. The only available treatment for cataract is surgery. Surgery requires highly- … of life outcomes and validated outcome measures in terms of visual acuity, contrast sensitivity and glare, and large enough to detect adverse effects.

Palliative prognostic scores for survival prediction of cancer patients: a systematic review and meta-analysis.

BACKGROUND: The palliative prognostic score is the most widely validated prognostic tool for cancer survival prediction, with modified versions available. A systematic evaluation of palliative prognostic score tools is lacking. This systematic review and meta-analysis aimed to evaluate the performance and prognostic utility of palliative prognostic score, delirium-palliative prognostic score, and palliative prognostic score without clinician prediction in predicting 30-day survival of cancer patients and to compare their performance. METHODS: Six databases were searched for peer-reviewed stud

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… For Lee et al. ( 68 ) and Glare et al. ( 56 ), in group A, the survival probabilities (69.4% and 66%, respectively) were slightly lower than expected (>70%). … Collegian . 2021 ; 28 ( 4 ): 431 - 437 . doi: 10.1016/j.colegn.2020.12.007 85 Glare P , Sinclair C , Downing M , Stone P , Maltoni M , Vigano A. Predicting survival in patients with advanced disease . …

[Comparison of the visual quality at 1 year following femtosecond laser-assisted LASIK, wavefront-guided femtosecond LASIK and small incision lenticule extraction for myopia and astigmatism].

Objective: To investigate mesopic contrast sensitivity (CS) and high-order aberrations after femtosecond laser-assisted LASIK (FS-LASIK), wa … ich was more than that of the FS-LASIK and SMILE groups (Z=-3.194, -2.977, P=0.001, 0.003). CS with glare of the WF-LASIK group at 12.0 c/d increased from 1.26 (1.18, 1.34) to 1.34 (1.34, 1.63) (Z=-3.608, P=0.000), which was more than that of the FS-LASIK and SMILE groups (Z=-4.033, -2.913, P=0.000, 0.004). Conclusions: FS-LASIK, WF-LASIK and SMILE achi …

Age related macular degeneration and visual disability.

Age-related macular degeneration (AMD) is the leading cause of central blindness or low vision among the elderly in industrialized countries … with macular degeneration. In principle, one aims both at reducing short-wavelength light to reduce glare and at identifying light with specific wavelengths (colours) preferred by the patient for viewing. In both instances, such interventions result in apparent improved contrast sensitivity and better visual acuity. Although specific tests are performed …