Результаты поиска

Propranolol plasma monitoring in children submitted to surgery of tetralogy of Fallot by a micromethod using high performance liquid chromatography.

OBJECTIVE: To evaluate the analytical micromethod using liquid chromatography for the quantification of propranolol in children submitted to … at preceded the day of surgery. Plasma concentration also was normalized with hematocrit due to the hemodilution caused by the CPB procedure. On the other hand a decrease on drug plasma concentration was obtained between periods, the beginning of surgery to the postoperative day 2 (7.09 ng/mL and 0.05 ng/mL, p<0.05 respectively) and from the end of CPB to the …

Transcranial Doppler monitoring and clinical decision-making after subarachnoid hemorrhage.

Our objective was to examine the impact of transcranial Doppler ultrasound (TCD) vasospasm monitoring on clinical decision-making following subarachnoid hemorrhage (SAH). The records of 50 randomly selected patients undergoing serial TCD monitoring following SAH were reviewed. Dates and results of TCDs and cerebral angiograms, the use of hypertensive hemodilution (HH) therapy, and the development of new neurological deficits were recorded. The independent effects of TCD-defined vasospasm and new neurological deficits on patient management were determined with multiple logistical regression. Re…

[A new hydroxyethyl starch for volume replacement: Elohes 6%].

Various consensus groups convened in recent years to discuss plasma volume expansion solutions have suggested limiting the use of human albu … ts on coagulation depend on molecular weight and duration of HES administration. Only in studies of hemodilution lasting 10 days with 6% HES 200/0.62 has VIII/von Willebrand complex been shown to decrease. If the recommended daily dose of this HES is respected, however, coagulation disorders are minimal. The effect of HES on kidney function is at present a sub …

[A comparative study of the effectiveness of 5% human albumin and 10% hydroxyethyl starch (HAES-steril) for correcting hemodynamics and O2 transport in surgical interventions].

Forty patients subjected to cavitary operations were examined. A high risk of hemodynamic disorders necessitated invasive monitoring; with this aim in view a catheter was inserted for measuring arterial pressure and the Swan-Ganz catheter for measuring the pressure in the pulmonary artery, in which helped monitor the hemodynamics and oxygen transport in the course of hypervolemic hemodilution. Plasma substitutes (one of two) were selected at random. After catheterization of the left radial artery and insertion of the Swan-Ganz catheter in the pulmonary artery through the internal right jugular…

Crystalloid versus colloid for fluid resuscitation of hypovolemic patients.

The choice of the initial asanguinous fluid--either crystalloid or colloid--used for the resuscitation of the hypovolemic patient remains controversial. Colloid supporters argue for the careful preservation of the plasma colloid osmotic pressure (PCOP) to protect the lung from pulmonary edema. A careful analysis of the Starling microvascular forces operative at the pulmonary capillary makes such an effect unlikely. In fact, the lung is relatively immune to hemodilution and any decrease in PCOP is roughly one fourth as important as increases in hydrostatic pressure in causing increased fluid ex…

Tailoring cardioplegia delivery circuits with modular heart-lung machines: A narrative review.

BACKGROUND: Cardioplegia remains a cornerstone of myocardial protection during cardiac surgery; however, the configuration of its delivery circuit, particularly priming volume and blood-synthetic surface area, can exert a measurable influence on patient outcomes. Oversized or non-tailored circuits inherently increase hemodilution, inflammatory activation, and coagulation disturbances, effects that are especially pronounced in neonates and small children, whose circulating blood volume is limited. Advances in modular heart-lung machine (HLM) technology have introduced the possibility of tailori…

Applications of Multiparameter Flow Cytometry in the Diagnosis, Prognosis, and Monitoring of Multiple Myeloma Patients.

Multiple myeloma (MM) is one of the most common hematological malignancies and remains incurable. However, the survival of multiple myeloma … populations, assessing cellularity, immunophenotypic characteristics of plasma cells, and possible hemodilution. This review explores the applications of MFC and NGF in MM, highlighting their roles in diagnosis, response assessment, and prognosis. Beyond their established use in MRD monitoring, flow cytometry-derived immunophenotypic profiles show strong pote …

Optimizing patient blood management through intraoperative goal-directed fluid therapy protocol within an enhanced recovery after cardiac surgery program.

OBJECTIVE: This study assessed the impact of intraoperative goal-directed fluid therapy integrated within an Enhanced Recovery After Surgery … oal-directed fluid therapy within an Enhanced Recovery After Surgery program reduces intraoperative hemodilution, improves coagulation integrity, reduces postoperative bleeding, decreases transfusion needs, and maintains end-organ perfusion after elective cardiac surgery.

Клиническое применение возрастных отсечек для световых цепочек плазменной нейрофильтрации в множественных склерозах.

ЦЕЛЬ: Клиническое использование световых цепочек нейрофильтрации (NfL) требует таких пороговых значений, которые отражают состояние болезней независимо от таких смешающих факторов, как возраст, гемодилиз и сердечно-сосудистые факторы риска. Мы сравнили результаты различных ранее предложенных пороговых значений при разделении случаев с НР и контроля, а также при выявлении различных клинических особенностей НР в разбивке по возрастным группам. МЕТОДЫ: В этом перекрестном исследовании мы включили людей с MS (n = 312) и с учетом возраста, пола и eGFR-сопоставимости (n = 236). Что касается случаев

Совпадение в аннотации оригинала
OBJECTIVE: Clinical use of neurofilament light chain (NfL) requires cut-off values that reflect disease status independently of confounding factors, such as age, hemodilution, and cardiovascular risk factors. We compared the performance of different previously suggested cut-offs in separating MS cases and controls, and in identifying different MS clinical fe…

Incidence and Risk Factors for Postoperative Visual Loss after Cardiac Surgical Procedures: A Systematic Review.

Postoperative visual loss (POVL) is an infrequent yet consequential complication that can follow cardiac surgical interventions. This system … ertension, postoperative edema, prolonged mechanical ventilation, micro-embolization, inflammation, hemodilution, and hypothermia.While the overall incidence of POVL postcardiac surgery remains modest, its potential impact is substantial, necessitating meticulous consideration of modifiable risk factors. Notably, prolonged surgical duration, intraoperative hyp …

Red blood cell transfusion in liver resection.

BACKGROUND: Several modalities exist for the management of hepatic neoplasms. Resection, the most effective approach, carries significant ri … on, parenchymal transection techniques, hemostatic agents, antifibrinolytics, low central pressure, hemodilution, autologous blood recycling), and post-operative (normothermia, correction of coagulopathy, optimization of nutrition, restrictive transfusion strategy) methods. CONCLUSION: Blood loss during hepatectomy is common and several risk factors can be id …

Whole blood platelet aggregation kinetics under cardiopulmonary bypass: A pilot study.

Assessing the platelets' functional status during surgery on cardiopulmonary bypass is challenging. This study used multiple electrode imped … ± 37.2%; thrombin receptor activating peptide: +34.5% ± 18.5%). Thus, after an initial drop due to hemodilution upon establishment of cardiopulmonary bypass, platelet reactivity increased over time which was not outweighed by decreasing platelet counts due to mechanical platelet destruction and absorption. These findings have implications for rational transfu …

Does metabolic alkalosis influence cerebral oxygenation in infantile hypertrophic pyloric stenosis?

BACKGROUND: This pilot study focuses on regional tissue oxygenation (rSO2) in patients with infantile hypertrophic pyloric stenosis in a per … regarding hematocrite and mean r-rSO2, indirectly indicative of an increased renal blood flow under hemodilution, was obtained. CONCLUSIONS: NIRS seems suitable for the detection of a transiently impaired cerebral oxygenation under state of pronounced MA in infants with infantile hypertrophic pyloric stenosis. Correction of MA led to normalization of c-rSO2. …

Platelet closure time in anesthetized Greyhounds with hemorrhagic shock treated with hydroxyethyl starch 130/0.4 or 0.9% sodium chloride infusions.

OBJECTIVE: To measure platelet closure time (PCT) in dogs during controlled hemorrhagic shock and after fluid resuscitation with hydroxyethy … ased PCT. These results do not support that HES 130/0.4 causes relevant platelet dysfunction beyond hemodilution.

Operator auditory perception and spectral quantification of umbilical artery Doppler ultrasound signals.

OBJECTIVE: An experienced sonographer can by listening to the Doppler audio signals perceive various timbres that distinguish different type … ation of the placental bed (embolization model, 7 lamb fetuses, 370 Doppler recordings) or by fetal hemodilution (anemia model, 4 lamb fetuses, 184 recordings). A subjective 11-step operator auditory scale (OAS) was related to conventional Doppler parameters, PI and time average mean velocity (TAM), and to sound frequency analysis of Doppler signals (sound fre …

Randomized controlled trial of 2 prenatal iron supplements: is there a dose-response relation with maternal hemoglobin?

BACKGROUND: The most appropriate dose of iron to prevent maternal anemia is still unclear. OBJECTIVE: We assessed the dose-response relatio … t supplementation, anemia remained highly prevalent during gestation, partly because of physiologic hemodilution. This trial was registered at clinicaltrials.gov as NCT00642408.

Continuous hemofiltration dose calculation in a newborn patient with congenital heart disease and preoperative renal failure.

OBJECTIVE: To report a case of a newborn patient with renal failure due to polycystic kidneys requiring renal replacement therapy, and total … y in the case of a 3-kg newborn patient with established renal failure needing major cardiosurgery: hemodilution secondary to CPB, transfusion of hemoderivates, and optimal UF rate appear to be effective methods for achieving solute removal. If postoperative continuous hemofiltration is started, however, a "dialytic dose" of 4.5 ml/min allows an adequate creat …

The effect of different volumes of fluid resuscitation on traumatic-hemorrhagic shock at high altitude in the unacclimated rat.

The effects of different volumes of fluid resuscitation on traumatic hemorrhagic shock in unacclimated rats to high altitude were investigat … significantly prolonged the survival time. Although 2 and 3 vol of LR resuscitation caused apparent hemodilution and lung edema, they only partially improved hemodynamic parameters. Meanwhile 2 and 3 vol of LR resuscitation decreased the survival time. These results suggest that 1 and 1.5 vol of LR resuscitation can effectively resuscitate traumatic hemorrhagi …

Diagnostic concordance between bone marrow aspirate and trephine biopsy in hematological neoplasms and non-hematological marrow infiltrations.

Evaluating concurrent bone marrow aspirate (BMA) and trephine biopsy (BMB) specimens demonstrates significant diagnostic complementarity, reducing false-negative rates in plasma cell dyscrasias and marrow infiltrations, and proving that combined evaluation remains essential for accurate laboratory staging across diverse hematological malignancies. This retrospective study at the South Egypt Institute for Oncology evaluated 430 patients who underwent simultaneous BMA and BMB between December 2023 and December 2025 for suspected or confirmed malignancies. Inadequate samples, including hemodilute

Introduction of modified blood priming technique in the neonatal and infant populations undergoing congenital heart surgery.

BACKGROUND: Allogenic blood product transfusion has well-documented risks and adverse outcomes. To limit perioperative transfusions for neon … dioplegia (CPG) circuits is displaced into a syringe with circulating blood to minimize any further hemodilution. RESULTS: We have applied MBP to 26 patients weighing less than 7 kg. The mean amount of PRBC these patients received during CPB, including in the prime, was half the amount when compared to the initial amount of PRBC we include in our institution' …