Результаты поиска

Thiol-ene photoclick hydrogels reinforced with poly(protocatechualdehyde)-coated gallium doped bioactive glass nanoparticles for scarless healing of infected wound.

Complex pathological microenvironment mainly characterized by excessive inflammation, reactive oxygen species (ROS) production, drug-resista … nctions of the PPA@GaBG, the PGBGH hydrogel promoted angiogenesis, granulation tissue formation and re-epithelialization with improved deposition ratio of collagen III/I, which achieved the rapid scarless healing of infected wound.

Biomedical potential of alginate wound dressings - From preclinical studies to clinical applications: A review.

The challenge of impaired wound healing, particularly in diabetes, remains a significant concern in modern medicine. For this reason, new bi … s hydrogel-forming ability supports a moist wound environment, which is conducive to tissue repair, re-epithelialization, and collagen synthesis. Experimental models involving acute and chronic wounds have highlighted alginate's therapeutic potential. Incorporating zinc oxide nanoparticles, platelet-rich plasma, and other bioactive substances into alginate-based mater …

Potential Medical and Surgical Applications of Stromal Vascular Fraction and Adipose-Derived Stem Cells: A Narrative Review.

Adipose-derived cellular therapies, including stromal vascular fraction (SVF) and adipose-derived stem cells (ASCs), have demonstrated incre … arization, modulation of the inflammatory microenvironment, and promotion of granulation tissue and re-epithelialization. Across both indications, these therapies have shown a good safety profile, with minimal adverse events reported. The review also addresses regulatory distinctions, standardization challenges, and biologic variability, particularly in SVF preparatio …

GLP-1 Receptor Agonists as Emerging Modulators of Inflammation and Angiogenesis in Chronic Cutaneous Wound Healing.

Diabetic foot ulcers (DFUs) represent a clinically burdensome and pathophysiologically distinct complication of diabetes mellitus, marked by persistent inflammation, dysregulated immune signaling, impaired angiogenesis, and delayed re-epithelialization. Despite adherence to standardized wound care protocols, DFUs remain recalcitrant to healing, contributing to high rates of recurrence, infection, and lower extremity amputation. Although established in glycemic control, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) exert pleiotropic immunomodulatory and regenerative effects relevant to …

Treatment of chronic anal fissure in Crohn's disease patients with freshly collected autologous adipose tissue: a pilot study.

BACKGROUND: Chronic anal fissures in patients with Crohn's disease (CD) remain a significant therapeutic challenge, particularly when linked to active perianal disease. Conventional treatments often fail, highlighting the need for alternative approaches. This study explores the efficacy and safety of freshly collected autologous adipose tissue injection (AATI) for treating chronic fissures in patients with CD. METHODS: Nine patients with CD with anal fissures were included. The primary outcome was complete healing (CH) at 3 months after last AATI, defined as full fissure re-epithelialization …

Zinc Alginate Hydrogel-Coated Wound Dressings: Fabrication, Characterization, and Evaluation of Anti-Infective and In Vivo Performance.

The delayed healing and infection risks associated with chronic wounds and burns pose significant clinical challenges. Traditional dressings … ressing (46.58%), and spontaneous-healing (37.25%) groups. Histological analysis confirmed enhanced re-epithelialization, neovascularization, and reduced inflammation in WD@AlgZn-treated tissues. The findings suggest that WD@AlgZn offers a promising alternative for advanced wound management, combining structural robustness with bioactive properties to support efficien …

Тематическая доставка 4-аминопиридина усиливает процесс регенерации кожи в обожженных ранах.

Обжигающие раны представляют собой обычное травматическое повреждение, которое ухудшает клеточную функцию и затрудняет процесс выздоровления, часто приводящее к значительным потерям кожи. Хотя автологический пересадка кожи считается золотым стандартом для обработки ожогов, ее широкое применение ограничено из-за заболеваемости на местах у доноров и потребности в больших количествах тканей. Традиционные повязки и методы лечения ран часто не обеспечивают полного выздоровления. Поскольку первоначально УЛХ одобрило лечение множественных склерозов, было также продемонстрировано, что 4-аминопиридин (

Совпадение в аннотации оригинала
Burn wounds are a common traumatic injury that impair cellular function and hinder the healing process, often resulting in significant skin … ver, our in vivo experiments showed that the 4-AP loaded gel accelerates wound healing by enhancing re-epithelialization and hair follicle regeneration and promoting fibroblast to myofibroblast transformation, which supports extracellular matrix remodeling after skin burns. This novel application of the 4-AP gel could offer a promising alternative to current burn woun …

Highly bioactive triple-helical nano collagens for accelerated treatment of photodamaged skin.

Skin damage caused by excessive UV exposure has gradually become one of the most common skin diseases, leading to desquamation, scab formati … ysis further demonstrates their capability of promoting the healing of damaged skin by accelerating re-epithelialization and collagen regeneration. These highly bioactive triple-helical nano collagens present a novel strategy for the treatment of UV-damaged skin, providing promising applications in cosmetics and dermatology.

Successful Management of Chronic Wounds by an Autophagy-Activating Magnetized Water-Based Gel in Elderly Patients: A Case Series.

Chronic wounds pose a significant threat to human health, particularly for the elderly, and require extensive healthcare resources globally. … d wound healing, as indicated by reduced fibrous and necrotic tissue, granulation tissue formation, re-epithelialization, and partial or complete wound closure. These preliminary case studies suggest that a topical gel containing magnetized saline water, which promotes autophagy, may aid healing of chronic wounds in elderly patients. Further investigation is warranted …

Chitosan nanoparticles of new chromone-based sulfonamide derivatives as effective anti-microbial matrix for wound healing acceleration.

A new series of chromone and furochromone-based sulfonamide Schiff's base derivatives 3-12 were synthesized and evaluated for their antimicr … he ability of CS-3aNPs to protect skin wounds was evaluated in vivo. CS-3aNPs showed complete wound re-epithelialization, hyperplasia of the epidermis, well-organized granulation tissue formation, and reduced signs of wound infection, as seen through histological assessment which showed minimal inflammatory cells in comparison with untreated wound. Overall, these find …

3D Bioprinting of Artificial Skin Substitute with Improved Mechanical Property and Regulated Cell Behavior through Integrating Patterned Nanofibrous Films.

Three-dimensional (3D) bioprinting has advantages for constructing artificial skin tissues in replicating the structures and functions of na … ctively accelerate the regeneration of large-area skin defects in mouse and pig models by promoting re-epithelialization and collagen deposition. This research developed an effective strategy to prepare composite bioprinting architectures for enhancing mechanical property and regulating cell behavior, and CASS could be a promising skin substitute for treating large-ar …

A suction blister model to characterize epidermal wound healing and evaluate the efficacy of the topical wound healing agent INM-755 in healthy volunteers.

Non-healing wounds represent a substantial medical burden with few effective treatments available. To address this challenge, we developed a … moval of epidermal sheet, enabling quantifiable measurements of wound healing parameters over time. Re-epithelialization was observed, revealing recovery of skin barrier function and perfusion. In the interventional study, differences of treatments over time were quantified using the above-described techniques. Despite differences from disease-specific blistering, our …

Efficacy and Safety of Carbon Dioxide Laser System in the Treatment of Scalp Sebaceous Adenoma With the Use of a New Scanner Unit.

Sebaceous adenoma (SA) is a rare solitary tumor that preferentially affects the forehead and scalp. The objective of this case report was to … e lesions treated while simultaneously protecting the surrounding areas, ensuring the best possible re-epithelialization.

Bone marrow-derived mesenchymal stem cells: A promising therapeutic option for the treatment of diabetic foot ulcers.

Chronic wounds fail to heal through the three normal stages of healing (inflammatory, proliferative, and remodelling), resulting in a chroni … actor secretion, anti-inflammation, differentiation into tissue-specific cells, neovascularization, re-epithelialization and angiogenesis in DFUs. Moreover, clinical trials showed that BMSC treatment in patients with diabetic ulcers improved ulcer healing and the ankle-brachial index, ameliorated pain scores, and enhanced claudication walking distances with no reporte …

Clinical Behavior of the Gingival Margin following Conservative "Coronally Dynamic" Restorations in the Presence of Non-Carious Cervical Lesions Associated with Gingival Recession: A Pilot Study.

Gingival recessions (GR) are often associated with the presence of non-carious cervical lesions (NCCL). The latter result in the disappearance of the cement-enamel junction (CEJ), with consequent difficulties both in measuring the recession itself and in performing root coverage techniques. The restoration of cervical lesions is consequently an important aspect in the treatment of GR, with the re-establishment of a "new" CEJ. This pilot study aimed to verify whether restorative therapy alone, with the execution of a restoration that mimics the convexity of the natural CEJ and thanks to a sligh

A New Postoperative Regimen after CXL and PRK Using Topical NSAID and Steroids on the Open Ocular Surface.

Corneal epithelium removal during photorefractive keratotomy (PRK), TransPRK, or corneal cross-linking (CXL) means that patients experience pain and inflammation after the procedure, which need to be carefully managed with topical drug regimens. One highly effective class of topical analgesics is non-steroidal anti-inflammatory drugs (NSAIDs), but these must be used carefully, as their use has been associated with delayed re-epithelialization and, in rare cases, corneal melting. However, our clinical experience has been that the concomitant use of topical corticosteroids obviates this risk. He…

Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications.

Wound management remains a worldwide challenge. It is undeniable that patients with problems such as difficulties in wound healing, metaboli … other properties (e.g., anti-inflammatory, bactericidal and immune regulation), to accelerate wound re-epithelialization, mimic skin structure and induce skin regeneration. Herein, in this review, we highlighted the importance of tailoring the physicochemical performance and biological functions of polysaccharide-based hydrogel wound dressings. We also summarized and …

Novel preparation of bilirubin-encapsulated pluronic F-127 nanoparticles as a potential biomaterial for wound healing.

Cutaneous wounds deteriorate the health of patients and liable for high economic loss. Previous studies showed promising wound healing poten … reduced inflammatory cells, more myofibroblasts, increased deposition of collagen fibres, and early re-epithelialization. The changes were prominent in bilirubin nanoparticles (0.3%) treated group indicating better granulation tissue, quality of healing and wound maturity. In conclusion, the proposed new encapsulated bilirubin nanoparticles strategy significantly impr …

A case of infectious crystalline keratopathy after corneal cross-linking.

PURPOSE: To present a case of infectious crystalline keratopathy after corneal cross-linking in a child with delayed wound healing, and its … cross-linking procedure, and the first to describe this phenomenon in a child with delayed corneal re-epithelialization. Though corneal cross-linking is a relatively safe procedure, atypical infections like crystalline keratopathy can occur in these patients in the setting of topical steroid use. Atypical organisms such as fungi should always be on the differential, …

5-hydroxymethylfurfural-embedded poly (vinyl alcohol)/sodium alginate hybrid hydrogels accelerate wound healing.

Treating large acute or chronic wounds remains a challenging task because of a lack of effective methods to accelerate wound healing. Though … ed inflammation, enhanced angiogenesis/vascularization, increased collagen production, and promoted re-epithelialization.