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Platelet-derived growth factor receptor-beta in Gorham's disease.

BACKGROUND: A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good … vated circulating platelet-derived growth factor-BB. MANAGEMENT: Spine stabilization, thalidomide, celecoxib, interferon-alpha2b, pamidronate, zoledronate, thoracotomy, pleurectomy, talc pleurodesis, and imatinib mesylate.

Efficacy of COX-2 inhibitors in a case of congenital nephrogenic diabetes insipidus.

A 17-month-old boy presented with failure to thrive, polyuria, and vomiting. He had been diagnosed clinically with nephrogenic diabetes insi … , both drugs were ineffective in controlling water diuresis. Thus, we had to replace these drugs by celecoxib (another selective cyclooxygenase-2 inhibitor). We conclude that the combination hydrochlorothiazide/amiloride/cyclooxygenase-2 inhibitor could be successfully used to treat congenital nephrogenic diabetes insipidus.

Current treatment of juvenile rheumatoid arthritis.

Prognostic factors in juvenile rheumatoid arthritis (JRA) include polyarticular onset, polyarticular disease course, and rheumatoid factor p … erated. Other recently approved agents for rheumatoid arthritis, including infliximab, leflunomide, celecoxib, and rofecoxib, have not been adequately studied in pediatric patients, and the role of these agents in children with JRA remains to be determined.

[Non-steroidal anti-inflammatory agents with selective inhibitory activity on cyclooxygenase-2. Interest and future prospects].

INTRODUCTION: Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the production of primary prostanoids by blocking the access of arachid … ts than standard NSAIDs, but which are not risk-free at high doses); 4) COX-2 selective inhibitors (celecoxib and rofecoxib). Preliminary clinical studies have shown that COX-2 selective inhibitors are as efficient as standard NSAIDs and have fewer adverse digestive side effects, thereby confirming the interest of this proposed classification. In the UK, th …

White adipose atrophy exacerbates cold stress and accelerates aging in male mice.

Adipose tissues are highly dynamic in response to environmental temperature changes. During aging, subcutaneous white adipose tissues (WAT) … din E2 production, which mediates the elevation of core body temperature (CBT). Inhibiting COX-2 by celecoxib or thermotherapy by housing the lipoatrophic mice at 26 °C (normally 22 °C) ameliorates cold stress, restores CBT, reduces aging features, and extends lifespan. Our findings reveal that subcutaneous WAT atrophy and subsequent CBT elevation induced b …

Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.

A beta-carbonic anhydrase (CA, EC 4.2.1.1) from the bacterial pathogen Brucella suis, bsCA 1, has been cloned, purified, and characterized kinetically. bsCA 1 has appreciable activity as catalyst for the hydration of CO(2) to bicarbonate, with a k(cat) of 6.4 x 10(5) s(-1) and k(cat)/K(m) of 3.9 x 10(7) M(-1).s(-1). A panel of 38 sulfonamides and one sulfamate have been investigated for inhibition of this new beta-CA. All types of activities have been detected, with K(I)s in the range of 17 nM to 5.87 microM. The best bsCA 1 inhibitors were ethoxzolamide (17 nM), celecoxib (18 nM), dorzolamide…

Двойная роль оси COX-2/PGE2 в множественном склерозе: от патогенеза до фармакологического ингибирования.

Множественный склероз (MS) — хроническое нервное и демиелинирующее заболевание центральной нервной системы (CNS). Ось циклоксигеназы-2/простагландина Е2 (COX-2/PGE2) играет сложную и двойную роль в ее патогенезе. Хотя его регулирование, как правило, вызывает нейроинфламму, олигодендроцит апоптоз и демиэлизацию, некоторые рецепторы PGE2 (EP2/EP4) также могут выступать в роли посредника в защите. В экспериментальных моделях ингибирование COX-2 (с использованием целекоксиба или мелоксикама) или блокирование провоспалительных рецепторов (EP1/EP3) облегчает патологию заболеваний путем сокращения ин

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic neuroinflammatory and demyelinating disease of the central nervous system (CNS). The cyclooxygenase-2/p … tors (EP2/EP4) can also mediate protective effects. In experimental models, inhibiting COX-2 (using celecoxib or meloxicam) or blocking pro-inflammatory receptors (EP1/EP3) alleviates disease pathology by reducing immune cell infiltration and cytokine production and protecting oligodendrocytes via both COX-2-dependent and independent mechanisms. This review …

Conservative treatment for osteoid osteoma of the odontoid process of the axis: a case report.

BACKGROUND: Osteoid osteoma is a primary benign bone lesion, which constitutes about 10% of all primary benign bone tumors and 3% of all pri … of surgical risks and high expense. Considering the benign nature of osteoid osteoma, we prescribed celecoxib 200 mg per day to the patient. With the treatment, the patient's pain was alleviated gradually and the range of motion of the cervical spine also recovered to normal. At the two-year phone follow-up, the patient was free of symptoms. CONCLUSIONS: F …

Membranous nephropathy in a patient with ankylosing spondylitis: A case report.

RATIONALE: Renal complications in ankylosing spondylitis (AS) were rarely observed, and proteinuria associated with AS can be seen often due to amyloidosis in this kind of complications, while membranous nephropathy (MN) is seldom considered. This article reports a case of coexistence of AS and MN, to provide the exact relationship of these 2 entities and recognized some causes of renal involvement in AS. PATIENT CONCERNS: A 44-year-old female presented with pain of the left leg for 4 years and pedal edema for 2 weeks. DIAGNOSES: AS was diagnosed according to the patient's clinical manifesta

Assessment of drug allergy and determination of safe alternative medications: a retrospective observational study.

BACKGROUND: Drug hypersensitivity reactions (DHRs) represent a major clinical challenge because of their heterogeneous presentations and the … rsensitivity, 119 (61.0%) demonstrated a cross-reactive pattern involving two or more NSAID groups. Celecoxib was tolerated by all 238 challenged patients with isolated NSAID hypersensitivity or combined NSAID and beta-lactam hypersensitivity. Among 167 patients with beta-lactam hypersensitivity, 104 underwent a standardized alternative non-beta-lactam anti …

Active ingredients of Astragalus-ginseng against COPD-associated sarcopenia: network pharmacology and molecular dynamics simulations.

BACKGROUND: Chronic obstructive pulmonary disease (COPD)-associated sarcopenia is a critical comorbidity associated with high morbidity and … structed to identify hub genes using multi-centrality metrics. Molecular docking was performed with celecoxib as a positive control. Three independent 100 ns molecular dynamics (MD) simulations of the FMNT-PTGS2 complex were then performed, and the trajectories were analyzed using the Simulation Interaction Diagram (SID) tool. RESULTS: We identified 1,267 …

Development of explainable machine learning models to predict side effects in patients with rheumatoid arthritis taking methotrexate treatment: a nationwide multicentre cohort study.

OBJECTIVES: Methotrexate (MTX) effectively controls rheumatoid arthritis (RA) but often leads to side effects (SE) such as gastrointestinal … ician visual analogue scale score, alanine aminotransferase, Health Assessment Questionnaire score, celecoxib use and drug adherence. Logistic regression confirmed statistical significance for multiple variables (eg, OR 4.63; 95% CI 1.41 to 20.90 for non-adherence >30 days; OR 1.45; 95% CI 1.14 to 1.85 for celecoxib use). DeLong's test indicated that boosti …

Different metabolism of hexose sugars and sucrose in wound fluid and in fibroblast cultures derived from granulation tissue, hypertrophic scar and keloid.

BACKGROUND AND OBJECTIVES: NSAIDs and cyclo-oxgenase (COX)-2-selective inhibitors have been associated with gastrointestinal (GI) complicati … drugs. RESULTS: Gastroprotective drugs were used by 22% of NSAID/COX-2-selective inhibitor users. Celecoxib, ketoprofen, meloxicam and etoricoxib were most commonly used concomitantly with gastroprotective drugs. Meloxicam and celecoxib were most strongly associated with gastroprotective drugs, after adjustment for age, sex and number of other drugs. Furt …

Comparative Metabolic Profiling and Anti-Inflammatory Evaluation of Ceiba speciosa and Ceiba insignis Flower Extracts.

Ceiba insignis and Ceiba speciosa are utilized in traditional medicine for treating inflammatory diseases. The analysis of their extracts by … aride stimulation, both extracts had anti-inflammatory effects like those of the control medication celecoxib, which decreased 5-LOX and TNF-α expression by 0.3554-fold and 0.2263-fold, respectively. Molecular docking highlighted that dihydrosterculic acid showed the tightest fit within 5-LOX center revealing binding energy (∆G = -35.09 kcal/mol). Consequen …

Research Progress of Cyclooxygenase-2 in Colorectal Adenomas.

BACKGROUND: Cyclooxygenase-2 (COX-2) serves as a pivotal molecule bridging inflammation and tumor development, playing a central role in the … ve COX-2 inhibitors have demonstrated clear promise in adenoma chemoprevention (with agents such as celecoxib reducing advanced adenoma recurrence risk by 33%-45%). CONCLUSIONS: COX-2 is a critical early-event biomarker and therapeutic target in colorectal adenomas. Targeting the COX-2 pathway represents a viable strategy for prevention, although challenge …

A Multimodal Analgesia Protocol to Reduce Opioid Use Following Oral Cavity Free Flap Reconstruction.

BACKGROUND: Opioid-based patient-controlled analgesia (PCA) is widely used after head and neck cancer surgery but carries risks such as dependence, sedation, and respiratory depression. Multimodal analgesia (MMA) may offer acceptable pain control with fewer adverse effects. METHODS: We retrospectively analyzed patients who underwent oral cavity resection with free flap reconstruction over 18 months. An MMA regimen of scheduled acetaminophen, celecoxib, and gabapentin was compared to PCA. Outcomes included opioid use, pain scores, and complications. RESULTS: A total of 237 patients were inclu…

Synthesis of Benzazolyl Oxadiazolyl/Thiadiazolyl/Triazolyl Amines and Their Antimicrobial, Antioxidant, In Silico and In Vivo Anti-Inflammatory Activities.

A new series of N2-(benzo[d]azolyl)-1,3,4-oxadiazole/thiadiazole-2,5-diamine derivatives (5a-c, 6a-c) and 5-(benzo[d]azolylamino)-4H-1,2,4-t … ted the highest anti-inflammatory activity among the tested derivatives, though slightly lower than celecoxib. The results suggest that benzo[d]azole-linked heterocycles represent promising scaffolds for further development of multifunctional bioactive agents.

Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis.

Berbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis … potential of different drugs (paclitaxel (PTL), gemcitabine, dexamethasone, doxorubicin (DOX), and celecoxib) in different models. Various attempts could fabricate biologically active derivatives of Ber, such as 4-chlorobenzoyl berbamine (CBB) and O-4- ethoxyl-butyl-berbamine (EBB). The review focuses on the medicinal applications of Ber, particularly anti …

Unveiling the methionine cycle: a key metabolic signature and NR4A2 as a methionine-responsive oncogene in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with notable metabolic reprogramming, yet the pivotal metabolic feature dri … ate that NR4A2 facilitates ESCC growth and negatively impacts patient survival. We further identify celecoxib as an effective inhibitor of NR4A2, offering promise as a new anti-ESCC agent. In summary, our findings underscore the active methionine cycle as a critical metabolic characteristic in ESCC, and pinpoint NR4A2 as a novel methionine-responsive oncoge …

The methionine cycle and its cancer implications.

The essential amino acid methionine is a crucial regulator of sulfur metabolism in a variety of interconnected biochemical pathways. The met … m6A methylation of NR4A2 mRNA, hence regulating proliferation in esophageal carcinoma. Accordingly, Celecoxib, a specific NR4A2 inhibitor, is a potentially powerful inhibitor of tumor growth at least in this specific model. Additionally, formaldehyde, from endogenous or exogenous sources, can directly regulate both SAM steady-state-levels and the one-carbon …