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Unusual Neurological Complications in a Patient With Monkeypox: A Case Report.

Monkeypox is a zoonotic disease caused by an enveloped single-stranded DNA virus that belongs to the Poxviridae family. It was first identified in humans in the 1970s. In 2022, a monkeypox outbreak spread extensively outside of endemic countries. Monkeypox infection begins with the prodromal symptoms of fever, myalgia, and lethargy, followed by the development of a characteristic maculopapular rash. In most cases, the illness is self-limiting. However, severe cases can lead to devastating neurological complications, such as encephalitis. Here, we present the case of a 31-year-old male patient

Monkeypox: epidemiology, mode of transmission, clinical features, genetic clades and molecular properties.

OBJECTIVE: Recently monkeypox cases have been reported from many non-endemic countries. The objective of this article is to bring out the epidemiology, mode of transmission, clinical features, genetic clades, and molecular properties of monkeypox virus. MATERIALS AND METHODS: A detailed literature review was conducted on monkeypox, using databases PubMed/Medline, EMBASE, PMC and Cochrane Library, for the period between 1985 to 2022. RESULTS: Genetically monkeypox virus can be classified into Central African clade and Western African clades. The sequence similarity between the two strains was…

Perceptions and worries about monkeypox, and attitudes towards monkeypox vaccination among medical workers in China: A cross-sectional survey.

BACKGROUND: The World Health Organization (WHO) declared monkeypox a "public health emergency of international concern" on 23 June 2022. How … answer to monkeypox transmission route (10.19, 5.42-19.17) were more likely to know about monkeypox/monkeypox virus before investigation. 30.7% reported that they were more worried about monkeypox than the coronavirus (COVID-19). Participants reported that the key population most in need of monkeypox vaccination were health practitioners (78.2%) and people with i …

Corneal Ulcer due to Monkeypox Infection.

PURPOSE: To report a rare case of keratitis due to monkeypox infection. METHODS: A 45-year-old male presented with an epithelial corneal ulcer 20 days following initial diagnosis of monkeypox from genital and perioral lesions. PCR analysis of the epithelium confirmed the presence of human monkeypox virus. RESULTS: The patient was hospitalized, and ganciclovir gel, as well as povidone iodine 0.6% and moxifloxacin eyedrops were prescribed. Oral tecovirimat 600 mg was administered during 14 days. A therapeutic contact lens was used. Twenty days after the initial diagnosis of keratitis, the corn…

Outbreaks of monkeypox and serological surveys in nonhuman primates.

In connexion with the recent detection of cases of monkeypox in man in West and Central Africa, the frequency of monkeypox outbreaks in monkeys since 1958, when the disease was first recognized in captive animals, has been investigated. Special incidence surveys were made for this purpose. During the last 3 years, a serological survey has been conducted to find natural foci of monkeypox virus, and a total of 2 242 sera from monkeys of different species from various parts of Africa and Asia have been examined for poxvirus antibodies. The survey failed to detect any significant indication of pox…

Ten-Week Follow-Up of Monkeypox Case-Patient, Sweden, 2022.

A previously healthy male patient had detectable monkeypox virus DNA in saliva 76 days after laboratory confirmation of infection. A comprehensive characterization of viral kinetics and a detailed follow-up indicated a declining risk for transmission during the weeks after monkeypox symptoms appeared.

[Evaluation of antibodies against mpox virus M1R].

The global outbreak of monkeypox in 2022 has aroused widespread concern in public health. To date, the prevention and treatment of monkeypox has mainly relied on smallpox vaccines and drugs. This study aims to screen and obtain therapeutic antibodies with high affinity, neutralizing activity, and protective effects, and provide candidate molecules for the development of specific therapeutic antibodies against monkeypox. Therefore, humanized mice were immunized to screen for antibodies against the envelope protein of the mpox virus. Two M1R-specific antibodies, 12G5 and 12H6, were obtained, wit

Monitoring of monkeypox viral DNA in Prague wastewater.

Monkeypox virus (Mpxv) is a dsDNA virus that has become a global concern for human health in 2022. As both infected people and non-human hosts can shed the virus from their skin, faeces, urine and other body fluids, and the resulting sewage contains viral load representative of the whole population, it is highly promising to detect the spread of monkeypox virus in municipal wastewater. We established a methodology for sewage-based monitoring of Mpxv in Prague and analysed samples (n = 24) already early August-October of 2022 in a municipality with 1.4 million inhabitants that only reported 29 …

Poxviruses isolated from clinically ill and asymptomatically infected monkeys and a chimpanzee.

Poxviruses were isolated from the kidneys of an outwardly healthy chimpanzee trapped in an area of the Democratic Republic of the Congo wher … s monkeys-although similar to one another differed markedly from the classical Copenhagen strain of monkeypox virus. These two viruses were characterized by the formation of small, monomorphic, well-defined pocks without haemorrhages on infected chick embryo chorioallantoic membrane, by the small plaques of the proliferative type that they produced in cell cultur …

An adult patient with suspected of monkeypox infection differential diagnosed to chickenpox.

BACKGROUND: Monkeypox is a zoonosis. The disease has a similar appearance to chickenpox caused by the varicella-zoster virus (VZV). On May 9th 2019, there was one laboratory-confirmed case of monkeypox reported in Singapore. A man was also suspected of having monkeypox on June 1st 2019 in Surabaya, Indonesia, a neighboring country. OBJECTIVE: To report on a suspected case of monkeypox with differential diagnosis to chickenpox. CASE: A 51-year-old male was suspected of having monkeypox after a differential diagnosis of chickenpox. His chief complaint was multiple blisters on his body. From th

Human Pathogenic Monkeypox Disease Recognition Using Q-Learning Approach.

While the world is working quietly to repair the damage caused by COVID-19's widespread transmission, the monkeypox virus threatens to become a global pandemic. There are several nations that report new monkeypox cases daily, despite the virus being less deadly and contagious than COVID-19. Monkeypox disease may be detected using artificial intelligence techniques. This paper suggests two strategies for improving monkeypox image classification precision. Based on reinforcement learning and parameter optimization for multi-layer neural networks, the suggested approaches are based on feature ext…

Ophthalmic Features and Implications of Poxviruses: Lessons from Clinical and Basic Research.

Amidst the ongoing monkeypox outbreak, global awareness has been directed towards the prevention of viral transmission and case management, with the World Health Organization declaring the outbreak a public health emergency of international concern. Monkeypox virus is one of several species in the Orthopoxvirus genus, with other species of the genus including the variola, cowpox, mousepox, camelpox, raccoonpox, skunkpox, and volepox viruses. Although the nomenclature of these species is based on the animal host from which they were originally isolated, transmission from animals to humans has b…

Обширная загадочная циркуляция поддерживает mopox среди мужчин, которые занимаются сексом с мужчинами.

Среди мужчин, вступающих в половые отношения с мужчинами, по-прежнему поступают сообщения об отдельных случаях применения клеща IIb mpox, при этом в большинстве случаев отсутствуют идентифицируемые каналы передачи. Для того, чтобы решить основные проблемы, мы провели тесты на наличие вируса обезьянопокс в аноректальных мазках у кого-то из мужчин, которые занимаются сексом с мужчинами в Лос-Анджелесе, за которым мы наблюдали одновременно для клинического диагноза Mpox летом 2024 года. Здесь мы подсчитали, что инфекция превысила зарегистрированные случаи заболевания мпоксом в 33 раза (95% довери

Совпадение в аннотации оригинала
Sporadic cases of clade IIb mpox continue to be notified among men who have sex with men, with most lacking identifiable transmission links. To resolve underlying dynamics, we tested prospectively for evidence of monkeypox virus infection in anorectal swabs from a cohort of men who have sex with men in Los Angeles, whom we monitored concurrently for clinical…

Epidemiological, clinical and virological characteristics of four cases of monkeypox support transmission through sexual contact, Italy, May 2022.

Since May 2022, an outbreak of monkeypox has been ongoing in non-endemic countries. We report four cases in Italy in young adult men reporting condomless sexual intercourse. The patients are in good clinical condition with no need for specific antiviral drugs. Biological samples from seminal fluid were positive for monkeypox viral DNA. For many other viruses found in semen there is no evidence of sexual transmission. The possibility of sexual transmission of monkeypox virus needs to be investigated.

Evidence of surface contamination in hospital rooms occupied by patients infected with monkeypox, Germany, June 2022.

The extent of monkeypox virus environmental contamination of surfaces is unclear. We examined surfaces in rooms occupied by two monkeypox patients on their fourth hospitalisation day. Contamination with up to 105 viral copies/cm2 on inanimate surfaces was estimated by PCR and the virus was successfully isolated from surfaces with more than 106 copies. These data highlight the importance of strict adherence of hospital staff to recommended protective measures. If appropriate, pre-exposure or early post-exposure vaccination should be considered for individuals at risk.

Monkeypox and pregnancy.

In May 2022, the World Health Organization reported an emerging global outbreak of monkeypox virus infection. Clinical manifestations of monkeypox allow us to quickly suspect the disease. Until now, no pregnant women infected with this virus have been reported; however, because of its speed of spread worldwide, it is possible that we will soon observe such cases. Thus, it is necessary for obstetrician-gynecologists to know the disease, its clinical manifestations, and the experiences reported in the few previous cases in pregnant women.

Human monkeypox transmitted by a chimpanzee in a tropical rain-forest area of Zaire.

A case of monkeypox infection in a six-month-old baby girl who had been bitten by a wild chimpanzee in Kivu, Zaire, was investigated. The child had not been exposed to any monkeypox-like disease and no cases of such disease had occurred in the surrounding area during previous months. The time of onset of rash was consistent with the virus having been transmitted from the chimpanzee. However, it is still not known whether chimpanzees and other primates or lower mammals are the primary reservoir of monkeypox infection.

Monkeypox: Virology, laboratory diagnosis and therapeutic approach.

Monkeypox infection outbreaks have been observed sporadically in Africa, usually as a result of interaction with wildlife reservoirs. The ge … mic repeats"). There are currently no particular, clinically effective treatments available for the monkeypox virus. An initial treatment is cidofovir. As a monophosphate nucleotide analog, cidofovir is transformed into an inhibitor of viral DNA polymerase by cellular kinases, which is analogous to cidofovir's function in inhibiting viral DNA synthesis. The Europ …

Потенциальная роль пассивной антителной терапии как лечения обезболивающего.

Обезьянопокс, зооноз, вызванный ортопоксическим вирусом обезьянопокс (МПXV), эндемичным для Центральной и Западной Африки, ранее был связан с спорадическими вспышками и редкими случаями, связанными с поездками. Вспышка обезьяны в 2022 году вызвала чрезвычайную ситуацию в области здравоохранения, вызывающую озабоченность международного сообщества, и эта вспышка является беспрецедентной с точки зрения ее масштабов и эпидемиологии. Вспышка была сосредоточена в основном на мужчинах, которые вступали в половые отношения с мужчинами; однако траектория вспышки остается неопределенной, и в настоящее в

Совпадение в аннотации оригинала
Monkeypox, a zoonosis caused by the orthopox monkeypox virus (MPXV) that is endemic to Central and West Africa, was previously linked to sporadic outbreaks and rare, travel-associated cases. An outbreak of monkeypox in 2022 has spurred a public health emergency of international concern, and this outbreak is unprecedented in terms of its scale and epidemiolog…