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[Guidelines for the management of chronic cough in adults].

Patients with chronic cough experience major alteration in their quality of life. Given its numerous etiologies and treatments, this disease … s indicate the pharmacological and non-pharmacological interventions of use in URCC. Amitriptyline, pregabalin, gabapentin or morphine combined with speech and/or physical therapy are mainstays in treatment strategies. Other treatment options, such as P2X3 antagonists, are being developed and have generated high hopes among physicians and patients alike.

Effectiveness of Gabapentinoids for Cancer-related Rectal and Vesical Tenesmus: Report of Four Cases.

Gabapentinoids could be assumed to relieve cancer-related rectal/vesical tenesmus based on their pharmacological mechanism. Four patients we … 66.7%, and 66.7%, respectively. The initiation dose of gabapentin was 200 or 400 mg/day and that of pregabalin was 75 mg/day in one patient. Gabapentinoids were effective at low doses administered over a short duration to patients with refractory cancer-related rectal/vesical tenesmus.

Low Dose Naltrexone in the Treatment of Fibromyalgia.

BACKGROUND: ConclusionFibromyalgia is a chronic pain disorder characterized by diffuse musculoskeletal pain, fatigue, sleep disturbance and cognitive impairment. OBJECTIVE: A significant number of fibromyalgia patients do not respond adequately to the current drugs approved by the Food and Drug Administration (FDA) for fibromyalgia treatment including pregabalin, milnacipran, duloxetine. Thus, there is still a need for adjunctive therapies. METHOD: Naltrexone is an opioid receptor antagonist used to treat alcohol and opioid dependence. It is hypothesized that low dose naltrexone causes trans…

[Diabetic asymmetric proximal neuropathy].

AIM: To study the prevalence, clinical features and treatment of diabetic asymmetric proximal neuropathy (DAPN). MATERIAL AND METHODS: Four … the definite myotome were key symptoms of DAPN. The efficacy of double therapy of neuropathic pain (pregabalin and duloxetine) and vitamin B complex was shown. A role of glucocorticoids and normal human immunoglobulin in treatment of DAPN is discussed.

[How neuropathic is sciatica? The mixed pain concept].

Different pathophysiological mechanisms are thought to operate in chronic sciatica. Nociceptive and neuropathic pain components can be disti … ., antidepressants such as amitriptyline and anticonvulsants such as gabapentin, carbamazepine, and pregabalin. Therefore, the combination of these analgesic compounds with NSAID could be useful in patients with sciatic pain who do not respond to NSAID.

Puberty-Onset Selective Mutism in a Female Adolescent With Autism Spectrum Disorder.

Selective mutism (SM) is a rare anxiety disorder typically diagnosed in early childhood. It is characterized by a persistent failure to spea … ASD. A multidisciplinary treatment approach involving cognitive behavioral therapy, fluoxetine, and pregabalin led to complete remission of SM and marked improvements in academic and social functioning. This case underscores the importance of recognising atypical anxiety presentations in adolescents with ASD and highlights the value of early, individualized, …

Trigeminal neuralgia: a practical guide.

Trigeminal neuralgia (TN) is a highly disabling disorder characterised by very severe, brief and electric shock like recurrent episodes of f … nostic work-up. Carbamazepine and oxcarbazepine are drugs of first choice. Lamotrigine, gabapentin, pregabalin, botulinum toxin type A and baclofen can be used either alone or as add-on therapy. Surgery should be considered if the pain is poorly controlled or the medical treatments are poorly tolerated. Trigeminal microvascular decompression is the first-lin …

Modern indications for the use of opipramol.

Opipramol is considered as a pharmacological agent that does not fit the classification taking into account the division of antidepressants, antipsychotics and anxiolytics. It has a structure related to tricyclic antidepressants but it has a different mechanism of action, i.e. binding to sigma1 and to sigma2 sites. It has been regarded as an effective drug in general anxiety disorders together with other agents like SSRI`s, SNRI`s, buspirone and pregabalin for many years. It can however also be indicated in other conditions, e.g. it may be used as a premedication in the evening prior to surger…

Prurigo nodularis: an update on etiopathogenesis and therapy.

Prurigo nodularis (PN) is a chronic, highly pruritic condition characterized by the presence of hyperkeratotic, excoriated, pruritic papules … no RCT are available and its use is impractical due to the unfavorable safety profile. Gabapentin, pregabalin and the neurokinin receptor 1 antagonist, aprepitant, seem also to be effective in the therapy of PN, but RCTs are still lacking.

Interpreting effect sizes and clinical relevance of pharmacological interventions for fibromyalgia.

Duloxetine, milnacipran, and pregabalin are approved by the United States Food and Drug Administration for the management of fibromyalgia. A number of meta-analyses, pooled analyses, and systematic reviews have been published in recent years involving the efficacy of these three medications for pain in fibromyalgia. Despite being based on the same clinical data, some analyses found these treatments to have a clinically relevant effect on pain, while others concluded that the advantages were small or of questionable clinical relevance. This commentary discussed possible reasons behind these dif…

[2013 vulvodynia update].

Provoked vestibulodynia represents the most frequent cause of dyspareunia before menopause. Vulvodynia's pain and burning sensations are rel … aphic biofeedback, drug treatment of pain with antidepressants (amitriptyline…) or anticonvulsants (pregabaline…) and a psychosexual support.

Управление герпесом Зостером и постгерпетической нейронгией.

Герпес зостер и его продолжение послегерпетической нейронгии (PHN) являются условиями с высокой заболеваемостью. ПХН представляет собой хроническую, изнуряющую нейропотическую боль, которая может сохраняться далеко за пределами разрешения видимых резких проявлений. В настоящем документе содержатся практические руководящие принципы управления герпесом-зостером и ПХН. Для герпеса-зостера противовирусные препараты должны начинаться, предпочтительно в течение 72 часов с момента начала, с тем чтобы уменьшить остроту и продолжительность изверженной фазы и уменьшить интенсивность острой боли. С ПХН м

Совпадение в аннотации оригинала
Herpes zoster and its sequela post-herpetic neuralgia (PHN) are conditions with significant morbidity. PHN is a chronic, debilitating neurop … gents can be considered (in decreasing order of recommendation): the anticonvulsants gabapentin and pregabalin, the tricyclic antidepressants amitriptyline, nortriptyline, and desipramine, and, lastly, the opioid analgesics tramadol, morphine, oxycodone, and methadone. For patients at high risk of developing PHN, early initiation of gabapentin or amitriptyli …

GABA-ergic drugs: exit stage left, enter stage right.

Drugs that enhance gamma-aminobutyric acid (GABA) activity by interacting at post-synaptic GABA(A) receptors have long been used as hypnotic … involving the GABA(A) receptor. These drugs include gabapentin, vigabatrin, tiagabine, lamotrigine, pregabalin and others. Although originally developed as anticonvulsants for epilepsy, they appear to have wider applications for use in affective disorders, especially bipolar depression, anxiety disorders and pain conditions. The current information on the pr …

Current management of pain associated with multiple sclerosis.

While pain is a common problem in patients with multiple sclerosis (MS), it is not frequently mentioned by patients and a more direct approa … ed with antiepileptics as first choice, e.g. carbamazepine, oxcarbazepine, lamotrigine, gabapentin, pregabalin, etc. Painful 'burning' dysaesthesias, the most frequent chronic pain syndrome, are treated with TCAs such as amitriptyline, or antiepileptics such as gabapentin, pregabalin, lamotrigine, etc. Combinations of drugs with different modes of action can …

Post-marketing safety evaluation of mirogabalin using the JADER database.

BACKGROUND: Mirogabalin, a novel third-generation α2-δ calcium channel ligand, is approved for diabetic peripheral neuropathic pain (DPNP). However, its post-marketing safety profile remains insufficiently characterized, particularly regarding novel signals and comparative safety profiles with established therapies. OBJECTIVES: This study aimed to identify and characterize adverse event (AE) signals associated with mirogabalin, evaluate demographic differences, and compare signal strength with pregabalin and gabapentin. METHODS: We conducted a pharmacovigilance analysis using the Japanese Ad…

Efficacy of Pulsed Radiofrequency or Short-Term Spinal Cord Stimulation for Acute/Subacute Zoster-Related Pain: A Randomized, Double-Blinded, Controlled Trial.

BACKGROUND: Postherpetic neuralgia (PHN) is the final stage of varicella zoster infection and a severe refractory neuropathic pain. Hence pr … -11) and the 36-Item Short Form Health Survey (SF-36) at different time points. The average dose of pregabalin (mg/d) administrated at different time points was also recorded. RESULTS: The posttreatment NRS-11 scores in the 2 groups were significantly lower compared with baseline (P < 0.001). The NRS-11 scores in the stSCS group were significantly lower tha …

Trends in Pain Relief in Cancer Patients: Pharmacotherapy and Medical Device Therapy.

The landscape of cancer pain management has evolved significantly with advancements in pharmacological and medical device therapies, shifting focus from opioid reliance to a multimodal treatment approach. This strategy emphasizes the use of non-opioid medications, including NSAIDs, acetaminophen, and adjuvant analgesics such as gabapentin and pregabalin, particularly for managing neuropathic pain. The emerging field of pharmacogenomics enhances personalized pain management, tailoring treatments to individual patient responses to minimize adverse effects and optimize drug efficacy. Additionally…

Prolonged and fluctuating consciousness after mixed overdose: navigating the complexities of polypharmacy, hepatic impairment and flumazenil use.

Mixed drug overdose presents a complex and potentially unpredictable clinical course, particularly in the presence of comorbidities that may alter drug metabolism, half-life and pharmacodynamic effects. We report a man in his 50s presenting with reduced consciousness, Glasgow Coma Scale (GCS) 11, requiring oxygen therapy after ingesting 100 mg diazepam, 1200 mg pregabalin and suspected co-ingestion of zopiclone and gabapentin. Flumazenil produced rapid but transient improvement. However, fluctuating consciousness persisted, with further deterioration in GCS on day 8 that again responded to flu…

Tracing illicit and prescription drug use in a Spanish prison by combining wastewater analysis and pharmaceutical dispensing data.

BACKGROUND AND AIM: We combined wastewater-based epidemiology (WBE) and pharmaceutical dispensing records to distinguish between illicit and … lysis showed high use of several pharmaceuticals, with the highest average PNDL for gabapentinoids. Pregabalin and gabapentin estimates from wastewater exceeded pharmacy dispensing, suggesting internal diversion. Cannabis consumption was about four times higher than community estimates and cocaine was also higher in all campaigns. Ketamine and MDMA use were …

Long-Term Tapentadol Use for Neuropathic Pain in a Hemodialysis Patient with End-stage Renal Disease: A Case Report.

BACKGROUND: Tapentadol is generally not recommended in patients with end-stage renal disease on hemodialysis due to concerns about metabolite accumulation and limited safety data. Evidence in this population is scarce, with no major trials to date. CASE REPORT: A 58-year-old man with end-stage renal disease on hemodialysis developed ischemic monomelic neuropathy after fistula surgery. Previous opioids and tramadol were ineffective; pregabalin, gabapentin, and oxcarbazepine caused intolerable side effects. Due to ongoing citalopram therapy, serotonin-norepinephrine reuptake inhibitor changes w…