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Anti-human T lymphocyte porcine immunoglobulin attenuates experimental autoimmune encephalomyelitis by inhibiting T cell activation.

Anti-human T lymphocyte porcine immunoglobulin (P-ATG) is a type of anti-thymocyte globulin (ATG) drug that has been used as an immunosuppressant for severe aplastic anemia and graft-versus-host disease for decades. However, the potential application of ATG for the direct treatment of Multiple sclerosis (MS) and the immune regulatory mechanisms are still unclear. In this study, the therapeutic effects and possible underlying mechanisms of P-ATG were evaluated in the rat model of experimental autoimmune encephalomyelitis (EAE), the animal model of MS. P-ATG could bind to T cells in both human a…

Identification of virulence-related amino acid mutations of avian encephalomyelitis virus associated with vaccination methods.

Avian encephalomyelitis virus (AEV), a picornavirus, primarily infects the central nervous system of 1 to 2-week-old young chickens but not pullets. When wild-type AEV undergoes serial passaging in chicken embryos, it becomes to be embryo-adapted and can cause avian encephalomyelitis in chickens of all ages following intracutaneous infection through parenteral routes. This study was conducted to explore whether an outbreak of AEV in 95-day-old chickens was linked to inadvertent embryo adaptation of the AEV vaccine and its association with vaccination method. In this study, an AEV strain AEV/JS…

Myelin-oligodendrocyte glycoprotein (MOG) antibody-associated acute disseminated encephalomyelitis (ADEM) in an adult with dengue.

Dengue is the most worldwide arbovirus and uncommonly causes encephalitis or acute disseminated encephalomyelitis (ADEM). Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has recently been recognized as a spectrum of monophasic or relapsing course demyelininating syndromes. We present the first case of MOGAD ADEM in an adult with dengue from Brazil. The patient was a 21-year-old man with no relevant medical or epidemiological history and a confirmed diagnosis of dengue with no warning signs after three days of classical clinical manifestations. In the next days, the pati…

Late Lyme neuroborreliosis encephalomyelitis with distinct MRI features-a case report and systematic literature review.

BACKGROUND: Central nervous system (CNS) Lyme neuroborreliosis (LNB) rarely occurs. Clinical and radiological findings are heterogenous and considered unspecific, often delaying the time to diagnosis and treatment. Recently, specific clinical courses and MRI patterns have been proposed for patients presenting with brainstem encephalitis, but their relevance remains unclear. OBJECTIVE: To describe radio-clinical features of patients with CNS-LNB encephalomyelitis, and to further investigate potential specific imaging patterns that could facilitate the diagnosis. METHODS: We report a case of l…

Pearls & Oy-sters: Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Presenting as Encephalomyelitis With Leptomeningeal Enhancement.

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an uncommon diagnosis in the differential for leptomeningeal enhancement. This case highlights the presentation, imaging features, and investigations important for diagnosis of GFAP astrocytopathy to ensure timely treatment of this corticosteroid-responsive disease. A 50-year-old man from Hong Kong presented with 10 days of progressive urinary retention, dysarthria, diplopia, and gait ataxia after a viral illness. Initial nonenhanced MRI brain was negative. After he developed encephalopathy, repeat MRI with gadolinium on admis

Targeted lipidomics dataset of central nervous system and plasma from mice with experimental autoimmune encephalomyelitis.

This dataset was generated from a preclinical study that used the relapsing-remitting experimental autoimmune encephalomyelitis (EAE) model in SJL/J mice to examine lipid signalling in neuroinflammation. The study examined how the reference compounds FTY720 (fingolimod, 0.5 mg/kg/day) affected the autotaxin/lysophosphatidic acid (ATX/LPA) axis and related lipid mediators. The mice were divided into three groups: control (no EAE), EAE, and EAE plus fingolimod. Tissue samples were collected from the plasma, cerebellum, hippocampus, and prefrontal cortex, resulting in 26 biological samples. Targe…

Половые особенности участия пептида кальцитонина, связанного с геном, сигнализирующего о боли в экспериментальном аутоиммунном энцефаломиелите.

ВВЕДЕНИЕ: Нейропическая боль (НФ) является одним из наиболее разрушительных и недостаточно управляемых симптомов множественного склероза (МС). В его нынешнем виде NP - это трудное состояние, которое нужно лечить, поскольку многие широко используемые методы болеутоляющего лечения неэффективны. В настоящее время проводятся исследования, свидетельствующие о гендерных различиях в механизме NP в MS, что усложняет поиск новых методов лечения. Хотя широко известно, что пациенты-женщины чаще, чем пациенты-мужчины, развивают СС, в меньшей степени признается тот факт, что у них также более высока вероят

Совпадение в аннотации оригинала
INTRODUCTION: Neuropathic pain (NP) is one of the most devastating and under-managed symptoms of multiple sclerosis (MS). As it stands, NP i … NP treatments specifically for female patients with MS. METHODS: Using the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, we have characterized the outgrowth in culture as well as the spinal innervation pattern of peptidergic primary sensory afferents in both sexes. We then used a receptor antagonist to disrupt neuropeptide signaling from these …

Liraglutide Attenuates Disease Severity in Experimental Autoimmune Encephalomyelitis by Modulating Splenic T Helper Cell Subsets.

OBJECTIVE: To investigate the therapeutic effects of liraglutide, a glucagon-like peptide-1 receptor agonist, on clinical progression and splenic T-cell subsets in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis. METHODS: EAE was induced in C57BL/6 mice via myelin oligodendrocyte glycoprotein immunization. The mice were divided into three groups: healthy controls (n = 8), EAE (n = 10), and EAE + liraglutide (n = 10). The EAE + liraglutide treatment group received subcutaneous liraglutide (10 µg/kg every other day) starting at 8 days postimmunization. Body…

Porphyromonas gingivalis усугубляет экспериментальный аутоиммунный энцефаломиэлит, проводя дифференциацию TH1 с помощью сигнала ZAP70/NF-IB.

Множественный склероз (MS) характеризуется хроническим воспалением и обезвоживанием в центральной нервной системе (CNS), главным образом в результате ненормальной активации периферической иммунной системы, в частности клеток TH1. Как основной патоген в периодонтрите, Porphyromonas gingivalis (P. gingivalis) связан с повышенным риском множественных склерозных прогрессий; однако его роль в центральной нервной системе воспаления остается неясной. В этом исследовании мы стремились определить, поощряет ли P. gingivalis периферическую дифференциацию клеток TH1 по сигнальному маршруту ZAP70/NF-InB, т

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is characterized by chronic inflammation and demyelination within the central nervous system (CNS), prim … differentiation via the ZAP70/NF-κB signaling pathway, thereby exacerbating experimental autoimmune encephalomyelitis(EAE), a model of multiple sclerosis. METHODS: C57BL/6J mice were randomly divided into healthy control, periodontitis, EAE, and periodontitis with EAE group. Neurological function was assessed using Weaver's score. Histopathology (H&E, LFB staining …

Ликопен дополнил средиземноморские диеты экспериментальными аутоиммунными энцефаломелитами (EAE) в мышах и изменениями кишечного микробиома.

Цель этого исследования заключалась в определении воздействия средиземноморского рациона питания (MD) и ликопена на развитие EAE и на подстрекательские маркеры. В 43-day :: исследование, 72 Женский C57BL/6 Мыши были случайно разделены на eight группы в зависимости от того, были ли они EAE или наивными (контрольными) мышами, питались западной диетой или MD, и получали ли они ликопен. Во время исследования мышей кормили ад-либитумом, а ликопиновые группы - ликопинами. 10 мг/кг/сут ликопен на мышь каждый день 28 днями в оральной желудке. Мыши были забраны за EAE, принесены в жертву, и их селезенк

Совпадение в полном тексте источника
… Although there is no study showing the effect of MD on Experimental Autoimmune Encephalomyelitis (EAE), there are studies showing that a diet low in total and saturated fat improves EAE (Ahn et al. 2014 ) and that MD components have positive effects on EAE (Unoda et al. 2013 ; Haghikia et al. 2015 …

Расположение RNA на основе RiboTag обнаруживает олигодендроглиевую воспаление в аутоиммунном энцефаломиелите: последствия для патогенеза.

Клетки олигодендроглиевой линии (ООК) необходимы для миелинирования, ремиелиции и нейронной метаболической поддержки, но недавние данные указывают на то, что они также играют активную роль в нейроинфламмации. Цель этого исследования состояла в том, чтобы выявить подстрекательский транслатом ОРЦ в начале экспериментального аутоиммунного энцефаломиэлита (EAE) - широко используемой модели множественного склероза (MS) с использованием последовательности РНК на основе RNA, основанной на RiboTag. Мы пересекли мышей Риботага Olig2-Cre Мыши для получения экспресс-выражения реберосомного белка HA-тагон

Совпадение в аннотации оригинала
Oligodendroglial lineage cells (OLCs) are essential for myelination, remyelination and neuronal metabolic support, but recent evidence suggests they also play active roles in neuroinflammation. This study aimed to identify the inflammatory translatome of OLCs during the onset of experimental autoimmune encephalomyelitis (EAE), a widely used model for Multipl…

Brain inflammation in experimental autoimmune encephalomyelitis induced in Dark Agouti rats with spinal cord homogenate.

We have recently characterized experimental autoimmune encephalomyelitis (EAE) induced in DA rats with spinal cord homogenate without complete Freund's adjuvant (CFA). The main advantage of this multiple sclerosis model is the lack of CFA-related confounding effects which represent the major obstacles in translating findings from EAE to multiple sclerosis. Here, antigen specificity of the cellular and humoral immune response directed against the central nervous system was explored. The reactivity of T and B cells to myelin basic protein, myelin oligodendrocyte glycoprotein, and β-synuclein was…

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity.

Recent studies provide some evidence for the contribution of antibody-mediated autoimmune mechanisms to the nature of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Much attention was paid to the autoantibodies (AAb) targeting G protein-coupled receptors as natural components of the immune system. However, the natural AAb network is much more extensive, and has not been previously investigated in these disorders. The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to determine changes in serum content of 33 natural AAb to neural, organ-spec…

MOG antibody-associated encephalomyelitis mimicking bacterial meningomyelitis following ChAdOx1 nCoV-19 vaccination: a case report.

We report a case of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalomyelitis following vector-based vaccination against SARS-CoV-2 that mimicked bacterial meningomyelitis upon initial presentation. A 43-year-old woman who had received a first dose of ChAdOx1 nCoV-19 (Vaxzevria; Astra Zeneca, UK Limited) 9 days earlier presented with subacute sensorimotor paraparesis, urinary retention, headache, meningism, and fever. Clinical findings and cerebrospinal fluid (CSF) features were highly suggestive of bacterial infection; however, despite receiving broad anti-infective…

Antiviral effect of lysosomotropic disaccharide trehalose on porcine hemagglutinating encephalomyelitis virus, a highly neurotropic betacoronavirus.

Many members of the genus Betacoronavirus are neurotropic viruses that frequently cause serious harm to humans or animals, including highly neurotropic porcine hemagglutinating encephalomyelitis virus (PHEV). Nevertheless, very few approved treatments exist to combat these viruses. Lysosomotropic trehalose, a widely used, nontoxic, natural disaccharide that can traverse the blood-brain barrier, has been proposed as a potential antiviral agent for use in prevention or treatment of betacoronavirus-associated infections. The purpose of this study was to determine if trehalose could inhibit PHEV i…

Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome.

BACKGROUND: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19) triggers the development of numerous patholo … n the COVID-19 infected cohorts, although many reported post COVID-19 symptoms overlap with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). AIMS OF REVIEW: In this study, COVID-19 clinical presentation and associated post-infection sequelae (post-COVID-19 condition) were reviewed and compared with ME/CFS symptomatology. KEY SCIENTIFIC CONCEPTS OF REV …

Induced pluripotent stem cells as suitable sensors for fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome.

BACKGROUND: Fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are devastating metabolic neuroimmune diseases that are difficult to diagnose because of the presence of numerous symptoms and a lack of specific biomarkers. Despite patient heterogeneity linked to patient subgroups and variation in disease severity, anomalies are found in the blood and plasma of these patients when compared with healthy control groups. The seeming specificity of these "plasma factors", as recently reported by Ron Davis and his group at Stanford University, CA, United States, and obse…

Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalitis Following COVID-19: Systematic Review and Meta-synthesis.

BACKGROUND AND OBJECTIVES: Since the onset of the COVID-19 pandemic, a growing number of reports have described cases of acute disseminated encephalomyelitis (ADEM) and acute hemorrhagic leukoencephalitis (AHLE) following infection with COVID-19. Given their relatively rare occurrence, the primary objective of this systematic review was to synthesize their clinical features, response to treatments, and clinical outcomes to better understand the nature of this neurologic consequence of COVID-19 infection. METHODS: Patients with a history of COVID-19 infection were included if their reports pro…

NAD+ improved experimental autoimmune encephalomyelitis by regulating SIRT1 to inhibit PI3K/Akt/mTOR signaling pathway.

Quantitative magnetic resonance imaging (MRI) volumetry has become a pivotal component in modern neurology, bridging the gap between detailed neuroimaging and clinical decision-making. By employing advanced imaging techniques like 3D T1-weighted, T2-weighted, and fluid-attenuated inversion recovery (FLAIR) sequences, MRI volumetry enables clinicians to objectively quantify brain volume changes associated with neurological conditions such as Alzheimer's disease, multiple sclerosis, epilepsy, and myotonic dystrophy. Automated segmentation tools, including FreeSurfer, NeuroQuant, volBrain, and Ac

Seropositive anti-MOG antibody-associated acute disseminated encephalomyelitis (ADEM): a sequelae of Mycoplasma pneumoniae infection.

Acute disseminated encephalomyelitis (ADEM) is a demyelinating, autoimmune disease of the central nervous system (CNS). It causes motor and sensory deficits, altered mental status and other neurological symptoms. Though rarely fatal, it has been associated with residual motor and neurocognitive deficits. Our case consisted of a 4-year-old girl who presented with fatigue and unsteady gait after a respiratory illness. During her hospital course, she became progressively weaker and experienced seizures. Imaging showed sections of demyelination in the CNS, and appropriate treatment was started. Ad…