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Saliva Immunoglobulin Concentrations Are Associated with Colostrum Intake and with Serum Concentrations in Newborn Calves.

The transfer of passive immunity (TPI) is vital for newborn calf health and is typically assessed through blood sampling to measure serum or plasma IgG or total protein levels. Saliva offers a less invasive alternative. This study evaluated the potential of saliva for assessing TPI. Saliva and serum samples were collected from 20 calves at birth and on days 1, 2, and 7 of life to measure IgG, IgA, IgM, and total protein concentrations. Colostrum fed to the calves was also analyzed for gross composition and immunoglobulin content. Colostrum intake and composition were associated with saliva IgG…

Comparison of IgG and lactoferrin levels in the serum and colostrum of holstein and buffalo cows and in their calves.

This study compared immunoglobulin G (IgG) and lactoferrin concentrations in the serum and colostrum of cows and buffaloes, as well as in the serum of their calves. A total of 20 dams (10 Holstein cows and 10 buffaloes) and their 20 calves (10 Holstein calves and 10 buffalo calves) were included. Blood samples were collected from all calves on days 0 (before colostrum intake), 1, 2, 7, 14, and 30. In addition, blood and colostrum samples were obtained from the dams on days 0, 1, and 2. IgG and lactoferrin concentrations were measured using enzyme-linked immunosorbent assay (ELISA) with species…

Antioxidant Capacity of Colostrum of Mothers with Gestational Diabetes Mellitus-A Cross-Sectional Study.

Background: Women with gestational diabetes mellitus (GDM) are vulnerable to oxidative stress, yet limited data exist on the antioxidant potential of their breast milk. This study aimed to evaluate the antioxidant capacity and basic composition of colostrum in women with GDM compared to healthy controls, focusing on total antioxidant capacity (TAC) and enzymatic antioxidants: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Methods: The study included 77 lactating mothers: 56 with gestational diabetes (15 managed with diet/exercise-GDM G1; 41 required insulin-GDM G…

Microneedle loaded with luteolin-colostrum-derived exosomes: a dropless approach for treatment of glaucoma.

Glaucoma, a leading cause of irreversible blindness, is marked by elevated intraocular pressure (IOP) and retinal ganglion cell death. Traditional IOP-lowering eye drops often fail to penetrate the ocular barrier, leading to suboptimal outcomes. Microneedles (MN), offer a promising minimally invasive and localized alternative. Our study aimed to formulate a naturally-derived nanodelivery system using Luteolin-loaded colostrum-derived exosomes (LUT-EX) and propolis in MN arrays for better ocular delivery. The isolated exosomes were uniform, averaging 50.83 nm in size, with a zeta potential of -…

Biochemical properties of sheep colostrum and its potential benefits for lamb survival: a review.

Colostrum is the initial secretion of the mammary glands following parturition, which offers main food, protection, and biological active substances for the new born. The most threatening episode of neonate's life is the initial two weeks after birth. This period is associated with high neonatal mortality and morbidity. These worthwhile losses lead to a poor prolificacy rate, low profitability, and ultimately poor performance in animal production. Hence, both diseases and mortality cause valuable losses in terms of production and economic losses. The survival of neonate is correlated with thei…

Success of replantation of avulsed teeth using human colostrum as an interim storage medium.

OBJECTIVES: Tooth avulsion is defined as total tooth displacement from the alveolar socket; the best treatment is replantation of the tooth. Human milk influences body health, growth, and development related to the presence of micro and macro nutrient components. This study assessed the effects of human colostrum as a storage medium on the success of tooth replantation. METHODS: The upper left incisor of 30 adult male Wistar rats was extracted, and the rats were divided into three groups according to the storage medium of the extracted tooth for replantation: Hank's balanced salt solution (HB…

Development of a method for isolating bovine colostrum mononuclear leukocytes for phenotyping and functional studies.

The present study reports a method for isolating bovine colostrum mononuclear cells (CMC) for phenotyping and functional studies. As well as being an important source of immunoglobulins, colostrum also contains leukocytes that may be of greater importance for passive immunity than has previously been thought. Different protocols have been reported for isolating leukocytes from bovine colostrum, although none of these have been validated, and phenotypic analysis of cell populations has not always been performed. In this study, bovine CMC were isolated by density gradient centrifugation. Cell po…

Effects of prolonged breastfeeding and colostrum fatty acids on allergic manifestations and infections in infancy.

BACKGROUND: In developed countries World Health Organization recommendation of 6 months' exclusive breastfeeding is under debate. OBJECTIVE: We assessed the impact of predominant breastfeeding (PBF) duration and colostrum long-chain polyunsaturated fatty acids (LC-PUFAs) profile on the risk of allergic manifestations (wheezing and atopic eczema) and infections [low respiratory tract infections (LRTIs) and gastroenteritis] in infancy. METHODS: Information on child feeding practices was obtained from 580 infants of a pregnancy cohort. Presence of infant's health outcomes was documented through…

Говядина колострум как биологическая в клинической медицине: обзор - Часть II: клинические исследования.

Ценность говяжьего колострума как биолога в медицине документально подтверждается клиническими испытаниями и подкрепляется относительно крупными базами данных, содержащими отчеты о конкретных случаях и отдельные выводы. Основные действия включают антибактериальный эффект и модуляцию иммунной реакции. Способность концентратов говяжьего колострума (БКЦ - это поливалентные концентраты говяжьего колострума, получаемые из колострумов нескольких 100 коров) нейтрализовать липополизакариды, т.е. эндотоксины, возникающие в результате гравитивных бактериальных патогенов, и ингибировать интерогенную эндо

Совпадение в аннотации оригинала
The value of bovine colostrum as a biologic in medicine is documented in clinical trials and supported by relatively large databases containing case reports and anecdotal findings. The main actions include an antibacterial effect and modulation of the immune response. The ability of bovine colostrum concentrates (BCC are polyvalent bovine colostrum concentra…

Development of the newborn GI tract and its relation to colostrum/milk intake: a review.

During the immediate postnatal period, the gastrointestinal (GI) tract undergoes profound growth, morphological changes and functional matur … enzymes and to absorb amino acids and glucose. These changes are apparently related to the onset of colostrum ingestion, because starved or water-fed newborns showed little changes in the GI tract. A number of hormones and growth-promoting peptides, such as insulin, cortisol, epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I), have been …

[The significance of antibodies to Pasteurella haemolytica A1 in the colostrum of cows and blood serum of calves].

Antibodies to P. haemolytica were detected in colostral sera of cows and blood sera of calves by means of indirect haemagglutination (IHA) and ELISA. The ELISA titres of the colostral sera of the dams and of the blood sera of the calves showed a significantly positive correlation. There is a positive correlation between the titres of the two serological methods. The results of the challenge infection with P. haemolytica A 1 do not show a correlation between the titres and the severity of the disease. Heifer calves, however, developed more severe pneumonias than calves from older cows.

[Content of essential metals in colostrum of women delivered by cesarean section in early puerperium].

The concentrations of magnesium, iron, copper and zinc were determined by atomic absorption spectrometry in the colostrum of 5 women in puerperium after delivery by Cesarean section. The samples of colostrum were obtained for examination between 11 and 12 hours on puerperium days from 4th to 7th. A significant rise of the concentration between these days was noted only in the case of iron (p less than 0.05). The differences in the levels of other metals over time period were random. The daily supply of these elements with milk to the breast-fed newborn increased evidently in that time period. …

Remission of diarrhoea due to cryptosporidiosis in an immunodeficient child treated with hyperimmune bovine colostrum.

A boy aged 6 months who presented with poor weight gain, diarrhoea, and infection with Pneumocystis carinii was found to have congenital hypogammaglobulinaemia, which did not improve despite monthly treatment with intravenous gammaglobulin. At the age of 3 years and 2 months he developed severe vomiting and diarrhoea due to cryptosporidiosis, which failed to respond to conventional treatment. Infusion of hyperimmune bovine colostrum produced against parasite antigen, given by nasogastric tube, was started after symptoms had persisted for three weeks. His vomiting and diarrhoea resolved within …

Periparturient alpha-lipoic acid supplementation improves ewe antioxidant status, colostrum quality, and lamb growth.

Alpha-lipoic acid (α-LA) is a potent antioxidant with potential to enhance ruminant health and productivity, yet its effects in late-pregnant ewes are not well defined. This study evaluated α-LA supplementation (600 mg/day) from 60 days prepartum to 8 weeks postpartum on blood biochemistry, immunity, colostrum and milk composition, microbiological quality, and lamb performance in Egyptian ewes. Thirty ewes were randomly allocated to control or α-LA groups (n = 15). On day one postpartum, α-LA ewes had higher serum albumin (2.87 vs. 2.45 g/dL), globulin (2.76 vs. 2.58 g/dL), total protein (5.64…

Periparturient Changes in Maternal Body Temperature and Colostrum Physicochemical Characteristics in Rasa Aragonesa Ewes.

Accurate identification of the periparturient period is essential for improving reproductive management in sheep. This study evaluated changes in maternal temperature and colostrum physicochemical characteristics during the transition from late gestation to early lactation. Seventeen pregnant ewes were monitored from 36 h before to 36 h after lambing. Vaginal and rectal temperatures were measured by digital thermometry, udder surface temperature by infrared thermography, and colostrum calcium, Brix value and pH were assessed using rapid field methods. Vaginal and rectal temperatures decreased …

Dietary fiber sources affect reproductive and lactation outcomes and colostrum protein concentration in sows.

This study aimed to evaluate the effects of supplementing different dietary fiber sources during late gestation. A total of 400 sows (parity 1-5; 215.7 ± 22.8 kg) were allocated in a randomized block design with four treatments: control (no added fiber), soybean hulls, lignocellulose, and micronized citrus pulp (n = 100 per treatment). Diets were isoenergetic and isonitrogenous, differing only in fiber source, and were provided from day 89 of gestation to weaning. Reproductive traits, piglet performance, fecal score, serum biochemical parameters, and colostrum yield and composition were evalua…

Comparison Between Antenatal and Postnatal Colostrum From Women With and Without Type 1 Diabetes.

BackgroundSupplementary feeding, colostrum or, in some countries, commercial milk formula, is given to newborns of women with Type 1 diabetes to prevent neonatal hypoglycemia. Few studies have explored the content of colostrum from women with Type 1 diabetes.Research AimsThis study aimed to investigate the macronutrients in colostrum collected during pregnancy and in the early postpartum period to compare colostrum contents in women with and without Type 1 diabetes.MethodsIn this cohort study, we collected colostrum among 20 women, 10 with and 10 without Type 1 diabetes, at 10 different time p…

Isolation, characterization, and immunomodulatory activity evaluation of probiotic strains from colostrum and canine milk.

BACKGROUND: This study aimed to characterize potential probiotic strains for use in dogs to prevent infectious enteropathies. Lactic acid bacteria (LAB) isolated from canine milk and colostrum were characterized according to their functional properties, including their resistance to gastrointestinal conditions, inhibitory effect against pathogens, and intestinal adhesion. METHODS: The immunomodulatory effects of the strains were also analyzed in in vitro and in vivo studies. Among the strains evaluated, two LAB strains (TUCO-16 and TUCO-17) showed remarkable resistance to pH 3.0, bile salts, …

Probiotic characteristics of bacteriocin-producing Enterococcus faecium strains isolated from human milk and colostrum.

As potential probiotic traits of human milk-isolated bacteria have increasingly been recognized, this study aimed to evaluate the probiotic properties of bacteriocin-producing Enterococcus faecium strains isolated from human milk and colostrum. Among 118 human milk- and colostrum-isolated lactic cocci, only 29 were identified as Enterococcus. Of these, only four Enterococcus faecium isolates exhibited bacteriocigenic activity against several pathogenic Gram-positive bacteria, including Listeria monocytogenes. These isolates exhibited high acid (up to pH 3.0) and bile tolerance (0.5% oxgall) in…