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Пересадка печени от вирусного гепатита.

В настоящее время показатель выживаемости за один год, составляющий 73-83% для выборочной трансплантации и 55-70% для экстренной трансплантации, делает трансплантацию печени надлежащим лечением как хронического заболевания печени на конечной стадии, так и острой недостаточности печени. Необходимо как можно скорее определить кандидатов на трансплантацию в случае острой недостаточности печени и описать модель отбора с использованием клинических критериев. Периодическая вирусная инфекция после трансплантации является либо возможной, либо доказанной проблемой во всех подгруппах пациентов, но наибо

Совпадение в аннотации оригинала
Current one year survival rates of 73-83% for elective transplantation, and 55-70% for emergency transplantation, render liver transplantati … proven problem in all patient subgroups, but the clearest manifestation is in patients with chronic hepatitis B infection. In our series of 29 patients surviving at least 60 days after transplantation, 41% died as a consequence of recurrent infection at 3-13 months. Delta virus infection appears to confer some protection in this regard, and the role of long …

Carbimazole-induced acute cholestatic hepatitis.

A case of carbimazole-induced cholestatic hepatitis is presented. A woman received carbimazole for hyperthyroidism for 3 months. Five months later, she had prompt recurrence of cholestasis parameters after rechallenge (2 days of treatment). Histologic examination showed predominantly centrilobular cholestasis. Only 5 other cases have been published in the literature. An idiosyncratic mechanism seems likely.

[Granulomatous hepatitis in cytomegalovirus infection].

Authors report the serologically verified CMV hepatitis of a 35-year old man whose hepatic alteration appeared in the form of a granulomatous hepatitis. On this account the characteristics of granulomatous hepatitis cases published so far in the literature are surveyed.

Posttransfusion hepatitis in Toronto, Canada.

Five hundred seventy-six consecutive patients from the surgical, obstetrical, and medical services who had received transfusions of volunteer blood were followed-up at regular intervals for 6 mo. Fifty-three (9.2%) developed acute posttransfusion non A, non B hepatitis. Forty-seven (89%) had an incubation period between 2 and 8 wk. The frequency was not related to the age or sex of the patient, the indications for transfusion, the type of surgery, anesthesia, the presence of perioperative hypotension, or the number of units of blood transfused. There were no cases of fulminant hepatitis. Ninet…

Chronic hepatitis: pathogenesis and treatment.

Current therapies for chronic viral hepatitis, autoimmune "lupoid" chronic active hepatitis, and drug-induced chronic hepatitis are discussed in the context of recent advances in our understanding of the pathophysiology of chronic active liver disease. Accurate diagnosis is the cornerstone of proper treatment; the limitations and pitfalls of conventional techniques are discussed. Current theories of the pathogenesis of chronic hepatitis B are reviewed to provide a framework for the use of antiviral drugs. Data from the early results of therapy with adenine arabinoside, acyclovir, and immunomod…

[Meningoradiculitis associated with hepatitis A].

The case of an eight year old boy affected by a meningoradiculitis in the prodromic phase of an acute hepatitis A is described. The diagnostic was confirmed (ac. anti-HAV-IgM). We point out the finding of this association which hasn't been described up to now.

Toxic hepatitis due to femoxetine.

A 51-year old woman treated with femoxetine--a new serotonin reuptake inhibitor with antidepressive effect--developed toxic hepatitis during the treatment. In spite of that, the elimination half-life of femoxetine in plasma was within normal limits.

Hepatitis B problem in Thailand.

HBV infection is hyperendemic in Thailand. Approximately 5 million Thais are chronic HBV carriers. The prevalence of HBV markers in general … hosis, 58%-66% of PHC and 35%-85% of cryptogenic cirrhosis with PHC were HBsAg positive. Studies on Hepatitis B immune globulin and Hepatitis B vaccine revealed a 70% and 56%, respectively, reduction in the HBsAg prevalence of infants born to HBsAg and HBeAg positive mothers. More epidemiologic, clinical and laboratory studies on HBV infection are being car …

[Amodiaquine-induced hepatitis with leukopenia].

Two patients are presented who during malaria prophylaxis with amodiaquine developed a hepatitis associated with granulocytopenia of short duration. The suspicion that this could be an adverse reaction to amodiaquine was confirmed by a reexposure to the drug.

Changing views on chronic hepatitis.

The histological classification of chronic hepatitis is reviewed. The relative importance of piecemeal necrosis and of lobular necrosis in the progression to cirrhosis is assessed. Recent advances in virological and serological aspects of acute hepatitis are outlined and the importance of concomitant infection with more than one virus is discussed. The pathologist cannot assess prognosis on a histological basis alone without other clinical and serological information.

[Granulomatous hepatitis caused by nomifensine].

Four patients are described who developed granulomatous hepatitis 4-6 weeks after treatment with nomifensin. The granulomas were located both in the portal tract and the liver parenchyma, and contained eosinophils and a few polynuclear giant cells. Serum alkaline phosphatase, alanine aminotransferase and bilirubin were raised in three, two and one patient respectively. After medication was discontinued all abnormalities disappeared within 6-10 weeks. After oral intake of 25-50 mg nomifensin all patients experienced paroxysms of high body temperature for several hours. Reexposure in one patient…

Viral hepatitis and the anaesthetist.

Viral hepatitis is a constant hazard to all operating room personnel. The anaesthetist should avoid contact with patients' blood and saliva as much as is possible. Hepatitis A (HAV) is spread mainly by faecal/oral contact. Carriers are almost non-existent in this disease and the main importance to the anaesthetist is that he may contact a patient who is acutely infected or one who is incubating HAV. Diagnosis of postoperative hepatic dysfunction may then be a problem. Prophylaxis with Gamma globulin is also stressed. Hepatitis B (HBV) and Non-A Non-B hepatitis (NANB) have a high incidence of c…

Toxic hepatitis following ketoconazole treatment.

Ketoconazole, a new broad-spectrum oral antifungal agent, has proved most useful in the treatment of superficial and systemic fungal infections. Chronic conditions like mucocutaneous candidiasis can be treated with but few side effects. An increasing number of cases have, however, been noted of severe toxic hepatitis, following ketoconazole treatment. A new case (a 61-yr-old woman treated for onychomycosis) is reported here.