The Journal of infectious diseases · 2025
Brain Imaging and Whole Blood Targeted Transcriptomic Analyses to Characterize Cerebral Infarctions in Children With Tuberculous Meningitis.
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Huynh Julie, Pretorius Pieter M, Jan Wajanat, Kachramanoglou Carolina, Le Nhat Hoang Thanh, Ngoc Van La, Hoang Hai Thanh, Tran Ny Thi Hong, Pham Tram Ngoc, Dang Do Thu Anh, Vu Dung Thi Mong, Tram Trinh Thi Bich, Vinh Do Dinh, Trinh Tung Huu, Qui Nguyen Dinh, Dang Minh Ha Thi, Frangou Elena, Santana Sierra, Muller Caitlin, Anderson Suzanne T, Gibb Diana M, Nguyen Nhung Thi Hong, Thuong Nguyen Thuy Thuong, Thwaites Guy
Аннотация
We characterized cerebral infarction in children with tuberculous meningitis and explored its relationship with systemic inflammatory mediators using targeted transcriptomic analysis. Children with tuberculous meningitis had baseline magnetic resonance imaging scans and whole blood RNA sequencing for matrix metalloproteinases (MMP-8, MMP-9, TIMP-1), cytokines (IL-10, IL-1β, TNF-α, IFN-γ), and growth factors (VEGF). Overall 22 (73%) children had mild disease and 19 (63%) had cerebral infarctions, which were commonly acute (n = 9, 47%), multiple (n = 14, 74%), and bilateral (n = 12, 63%), occurring in cerebral hemispheres (n = 12, 59%), basal ganglia (n = 10, 53%), and thalamus (n = 5, 26%). Children with infarctions had significantly higher cerebrospinal fluid protein, lower cerebrospinal fluid glucose, and higher systemic MMP-8 expression.