Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025
Hyperprocalcitonemia and Endothelial and Microcirculatory Dysfunction in Children With Sepsis and Septic Shock: Single-Center Observational Cohort Study in Colombia, 2021-2024.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Beltrán Hernandez Briam, Fernández-Sarmiento Jaime, Mulett Hernando, Niño Ariza Maria Carolina, Aguirre Gutierrez Valeria, Cárdenas Carolina, Cardona María Paula, Bernal Sierra Tatiana, Cabezas Rosas Marisol, Garzón Angel Lina, Sarta Mauricio, Fernández-Sarta Juan Pablo, La Rotta Isabella, Buelvas-Pérez Juanita, Rodriguez Laura Sofia, Barrera Suárez Maria José, Kissoon Niranjan, Microcirculation-Colombia (MICRO-COL) Research Group
Аннотация
OBJECTIVES: To evaluate the association between hyperprocalcitonemia and endothelial and microcirculatory dysfunction in children with sepsis and septic shock and clinical outcomes.
DESIGN: A prospective observational cohort study, 2021-2024.
SETTING: A tertiary PICU with 15 medical-surgical beds in a university hospital.
PATIENTS: We included children with sepsis and/or septic shock who had serum procalcitonin measured at admission, 24 hours, and 48 hours, simultaneously with microcirculatory assessment using sublingual videomicroscopy and biomarkers of endothelial injury (syndecan-1, angiopoietin-2, and endocan). Hyperprocalcitonemia was defined as procalcitonin greater than 2 ng/mL.
INTERVENTIONS: None.
MEASUREMENTS AND MAIN RESULTS: In 230 patients, 43.9% (101/230) had hyperprocalcitonemia at PICU admission. After adjusting for confounders, children with hyperprocalcitonemia, compared with those with normal procalcitonin, had higher adjusted odds ratio (aOR [95% CI]) of reduced capillary blood flow at 24 hours (aOR, 1.35 [95% CI, 1.08-1.72]) and 48 hours (aOR, 1.14 [95% CI, 1.04-1.24]) after admission. At 24 hours, children with hyperprocalcitonemia compared with those without hyperprocalcitonemia had higher median (interquartile range [IQR]) syndecan-1 levels (125.87 ng/mL [IQR, 49.56-224.30 ng/mL] vs. 107.71 ng/mL [IQR, 62.82-156.55 ng/mL], respectively; p < 0.01) and greater odds of angiopoietin-2 elevation (aOR, 2.28 [95% CI, 1.08-5.17]; p = 0.042). Hyperprocalcitonemia with severe endothelial/microcirculatory dysfunction was associated with fluid overload greater than 10% (aOR, 2.01 [95% CI, 1.06-3.80]; p = 0.033), multiple organ dysfunction (aOR, 1.87 [95% CI, 1.01-3.57]; p = 0.041), and mortality (aOR, 1.66 [95% CI, 1.06-2.61]; p = 0.022). We failed to identify differences in capillary density (4-6 µm), angiopoietin-2, or Endocan between children with and without hyperprocalcitonemia at PICU admission.
CONCLUSIONS: Children with sepsis and septic shock with hyperprocalcitonemia represent a phenotype characterized by endothelial and microvascular dysfunction, which is associated with worse clinical outcomes. Our study suggests that preserving microvascular integrity may be a therapeutic target to reduce microcirculatory damage and improve outcomes.
DESIGN: A prospective observational cohort study, 2021-2024.
SETTING: A tertiary PICU with 15 medical-surgical beds in a university hospital.
PATIENTS: We included children with sepsis and/or septic shock who had serum procalcitonin measured at admission, 24 hours, and 48 hours, simultaneously with microcirculatory assessment using sublingual videomicroscopy and biomarkers of endothelial injury (syndecan-1, angiopoietin-2, and endocan). Hyperprocalcitonemia was defined as procalcitonin greater than 2 ng/mL.
INTERVENTIONS: None.
MEASUREMENTS AND MAIN RESULTS: In 230 patients, 43.9% (101/230) had hyperprocalcitonemia at PICU admission. After adjusting for confounders, children with hyperprocalcitonemia, compared with those with normal procalcitonin, had higher adjusted odds ratio (aOR [95% CI]) of reduced capillary blood flow at 24 hours (aOR, 1.35 [95% CI, 1.08-1.72]) and 48 hours (aOR, 1.14 [95% CI, 1.04-1.24]) after admission. At 24 hours, children with hyperprocalcitonemia compared with those without hyperprocalcitonemia had higher median (interquartile range [IQR]) syndecan-1 levels (125.87 ng/mL [IQR, 49.56-224.30 ng/mL] vs. 107.71 ng/mL [IQR, 62.82-156.55 ng/mL], respectively; p < 0.01) and greater odds of angiopoietin-2 elevation (aOR, 2.28 [95% CI, 1.08-5.17]; p = 0.042). Hyperprocalcitonemia with severe endothelial/microcirculatory dysfunction was associated with fluid overload greater than 10% (aOR, 2.01 [95% CI, 1.06-3.80]; p = 0.033), multiple organ dysfunction (aOR, 1.87 [95% CI, 1.01-3.57]; p = 0.041), and mortality (aOR, 1.66 [95% CI, 1.06-2.61]; p = 0.022). We failed to identify differences in capillary density (4-6 µm), angiopoietin-2, or Endocan between children with and without hyperprocalcitonemia at PICU admission.
CONCLUSIONS: Children with sepsis and septic shock with hyperprocalcitonemia represent a phenotype characterized by endothelial and microvascular dysfunction, which is associated with worse clinical outcomes. Our study suggests that preserving microvascular integrity may be a therapeutic target to reduce microcirculatory damage and improve outcomes.