Tumori · 2021
Stereotactic body radiotherapy for T1 glottic cancer: dosimetric data in 27 consecutive patients.
СтатьяНазвание и аннотация: Перевод в очереди
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Sanguineti Giuseppe, Pellini Raul, Vidiri Antonello, Marzi Simona, D'Urso Pasqualina, Terrenato Irene, Farneti Alessia, Fuga Valentina, Ungania Sara, Landoni Valeria
Аннотация
AIM: Because the clinical feasibility of stereotactic body radiotherapy (SBRT) for early glottic cancer (T1) is controversial, we report dosimetric results in 27 consecutive patients from a prospective phase I and II study that started in 2017.
METHODS: In our approach, only the parts of the true vocal cord containing cancer and those immediately adjacent are planned to be treated to 36 Gy and 30 Gy, respectively, in 3 fractions. Several dosimetric metrics for both target volumes and organs at risk were extracted from individual plans and results were compared to those achieved by other authors in a similar setting.
RESULTS: Proper coverage was reached at planning in 2/3 of planning treatment volume 30 Gy, but only 4 planning treatment volume 36 Gy; conversely, the maximum dose objective was met for most of the patients on either arytenoid cartilage, but this was not the case for 51.9% and 96.3% of cricoid and thyroid cartilages, respectively. Our dosimetric results are similar to if not better than those achieved by others.
CONCLUSION: SBRT in 3 fractions for T1 glottic lesions is dosimetrically challenging. Clinical validation is awaited.
METHODS: In our approach, only the parts of the true vocal cord containing cancer and those immediately adjacent are planned to be treated to 36 Gy and 30 Gy, respectively, in 3 fractions. Several dosimetric metrics for both target volumes and organs at risk were extracted from individual plans and results were compared to those achieved by other authors in a similar setting.
RESULTS: Proper coverage was reached at planning in 2/3 of planning treatment volume 30 Gy, but only 4 planning treatment volume 36 Gy; conversely, the maximum dose objective was met for most of the patients on either arytenoid cartilage, but this was not the case for 51.9% and 96.3% of cricoid and thyroid cartilages, respectively. Our dosimetric results are similar to if not better than those achieved by others.
CONCLUSION: SBRT in 3 fractions for T1 glottic lesions is dosimetrically challenging. Clinical validation is awaited.