Spine · 2026
Neurologic Adverse Events Following Three-Column Osteotomy for Adult Spine Deformities: A Prospective Multicenter Study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Kim Andrew H, Sulieman Ahmed, Durand Wesley M, Raad Micheal, Lenke Lawrence G, Gum Jeffrey L, Hostin Richard A, Line Breton G, Lafage Virginie, Lafage Renaud, Hamilton D Kojo, Smith Justin S, Diebo Bassel G, Passias Peter G, Protopsaltis Themistocles S, Klineberg Eric O, Ames Christopher P, Daniels Alan H, Gupta Munish C, Schwab Frank J, Shaffrey Christopher I, Bess Shay, Burton Douglas C, Lee Sang Hun, Kebaish Khaled M, International Spine Study Group
Аннотация
STUDY DESIGN: Prospective, multicenter study.
OBJECTIVE: To compare and characterize complications in adult spinal deformity (ASD) patients with and without three-column osteotomy (3CO).
SUMMARY OF BACKGROUND DATA: Although 3CO is associated with increased risk of neurologic adverse events, no study has, to our knowledge, compared and characterized sensory and motor neurologic complications in ASD patients with versus without 3CO.
MATERIALS AND METHODS: Demographics, surgical characteristics, and neurologic complications were collected for 553 ASD patients. Lower extremity motor scores (LEMSs) were compared at baseline and postoperatively. Multivariate analysis was performed to identify risk factors associated with neurologic adverse events.
RESULTS: Among 553 ASD patients, 130 (23.5%) underwent 3CO. More patients with 3CO were revision patients (67.7% vs . 35.0%; P <0.001), presented with sagittal deformity (43.9% vs . 31.0%; P =0.008), and had longer operative times (455.6 vs . 407.3 min; P =0.001) and greater estimated blood loss (EBL) (1650 vs . 1000 mL; P <0.001) than patients without 3CO. The incidence of neurologic adverse events was greater among patients with versus without 3CO (23.1% vs . 15.4%; P =0.04). Multivariate analysis revealed that older age [odds ratio (OR) 1.288 per 10-year increase, 95% CI: 1.060-1.565, P =0.01] and longer operative time (OR: 1.088, 95% CI: 1.001-1.004, P =0.01) were significant predictors of neurologic adverse events. No between-group difference in LEMS was observed at six-week (49.0 vs . 49.0; P =0.90) or one-year (49.4 vs . 49.3; P =0.71) follow-up. By one-year follow-up, 20.5% of 3CO patients and 21.6% of patients without 3CO had residual motor deficit.
CONCLUSIONS: Compared with patients who did not undergo 3CO, more patients with 3CO had prior instrumentation, presented with sagittal deformity, had longer operative time and greater EBL, and were more likely to have a neurologic adverse event. At one-year follow-up, there was no significant difference in LEMS between the two groups.
LEVEL OF EVIDENCE: Level III.
OBJECTIVE: To compare and characterize complications in adult spinal deformity (ASD) patients with and without three-column osteotomy (3CO).
SUMMARY OF BACKGROUND DATA: Although 3CO is associated with increased risk of neurologic adverse events, no study has, to our knowledge, compared and characterized sensory and motor neurologic complications in ASD patients with versus without 3CO.
MATERIALS AND METHODS: Demographics, surgical characteristics, and neurologic complications were collected for 553 ASD patients. Lower extremity motor scores (LEMSs) were compared at baseline and postoperatively. Multivariate analysis was performed to identify risk factors associated with neurologic adverse events.
RESULTS: Among 553 ASD patients, 130 (23.5%) underwent 3CO. More patients with 3CO were revision patients (67.7% vs . 35.0%; P <0.001), presented with sagittal deformity (43.9% vs . 31.0%; P =0.008), and had longer operative times (455.6 vs . 407.3 min; P =0.001) and greater estimated blood loss (EBL) (1650 vs . 1000 mL; P <0.001) than patients without 3CO. The incidence of neurologic adverse events was greater among patients with versus without 3CO (23.1% vs . 15.4%; P =0.04). Multivariate analysis revealed that older age [odds ratio (OR) 1.288 per 10-year increase, 95% CI: 1.060-1.565, P =0.01] and longer operative time (OR: 1.088, 95% CI: 1.001-1.004, P =0.01) were significant predictors of neurologic adverse events. No between-group difference in LEMS was observed at six-week (49.0 vs . 49.0; P =0.90) or one-year (49.4 vs . 49.3; P =0.71) follow-up. By one-year follow-up, 20.5% of 3CO patients and 21.6% of patients without 3CO had residual motor deficit.
CONCLUSIONS: Compared with patients who did not undergo 3CO, more patients with 3CO had prior instrumentation, presented with sagittal deformity, had longer operative time and greater EBL, and were more likely to have a neurologic adverse event. At one-year follow-up, there was no significant difference in LEMS between the two groups.
LEVEL OF EVIDENCE: Level III.