Case Commentary: Successful use of olorofim for the treatment of multi-drug-resistant Lomentospora prolificans infection in a child.

Lomentospora prolificans is a multi-drug-resistant filamentous fungus that can cause invasive disease in both immunocompromised and immunocompetent hosts. Current treatment options are limited. Olorofim is an investigational antifungal that demonstrates activity against several different molds, including many that are resistant to other antifungals. The case presented by Fortini et al. (Antimicrob Agents Chemother 69:e00602-25, 2025, https://doi.org/10.1128/aac.00602-25) describes the successful use of olorofim treatment in an 8-year-old who suffered from Lomentospora prolificans tendonitis, synovitis, and osteomyelitis.