International journal of medical sciences · 2026
Pennisetum purpureum Schumach Supplementation Enhances Grip Strength in Adults with Low Muscle Mass: A Randomized Controlled Trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Huang Shih-Wei, Liu Ben-Mao, Lee Yu-Hao, Liu Megan F, Ochi Eisuke, Wei Chii-Horng, Yang Ming-Ta
Аннотация
BACKGROUND: Low muscle mass and reduced muscle strength are prevalent among adults, particularly in the aging population, and are associated with an increased risk of sarcopenia-related complications. Pennisetum purpureum Schumach is a plant known for its antioxidant properties, but its effects on muscle strength and function in adults with low muscle mass remain unexplored. In this study, we investigated the effects of Pennisetum purpureum Schumach supplementation on liver and kidney function, hormonal markers, anthropometric measurements, and physical performance in adults with low muscle mass.
METHODS: A 12-week randomized, double-blind, placebo-controlled trial was conducted with 35 participants with low muscle mass and reduced muscle strength. The experimental group received 300 mg of Pennisetum purpureum Schumach extract three times daily, while the placebo group received a placebo. Assessments included grip strength, muscle mass, liver and kidney function, and a 10-meter walk test at baseline, 8 weeks, and 12 weeks.
RESULTS: The experimental group showed a significant increase in grip strength (p < 0.05) after 8 and 12 weeks compared to baseline. No significant changes in muscle mass or performance in the 10-meter walk test were observed. Liver and kidney function remained unaffected in both groups.
CONCLUSION: Pennisetum purpureum Schumach supplementation was associated with an increase in grip strength after 8 and 12 weeks. No definitive effects were identified for muscle mass, walking performance, liver or kidney function, or hormonal markers. Observationally, some variability in testosterone levels was noted among male participants; however, the study lacked the design and statistical power necessary to determine hormonal effects. These findings suggest that the supplementation may be safe and potentially useful, although larger and parameter-comprehensive trials are required to verify physiological mechanisms and confirm efficacy.
METHODS: A 12-week randomized, double-blind, placebo-controlled trial was conducted with 35 participants with low muscle mass and reduced muscle strength. The experimental group received 300 mg of Pennisetum purpureum Schumach extract three times daily, while the placebo group received a placebo. Assessments included grip strength, muscle mass, liver and kidney function, and a 10-meter walk test at baseline, 8 weeks, and 12 weeks.
RESULTS: The experimental group showed a significant increase in grip strength (p < 0.05) after 8 and 12 weeks compared to baseline. No significant changes in muscle mass or performance in the 10-meter walk test were observed. Liver and kidney function remained unaffected in both groups.
CONCLUSION: Pennisetum purpureum Schumach supplementation was associated with an increase in grip strength after 8 and 12 weeks. No definitive effects were identified for muscle mass, walking performance, liver or kidney function, or hormonal markers. Observationally, some variability in testosterone levels was noted among male participants; however, the study lacked the design and statistical power necessary to determine hormonal effects. These findings suggest that the supplementation may be safe and potentially useful, although larger and parameter-comprehensive trials are required to verify physiological mechanisms and confirm efficacy.