Movement disorders : official journal of the Movement Disorder Society · 2014
Sensory tricks and brain excitability in cervical dystonia: a transcranial magnetic stimulation study.
СтатьяНазвание и аннотация: Перевод в очереди
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Amadio Stefano, Houdayer Elise, Bianchi Francesca, Tesfaghebriel Tekle Habtom, Urban Ivan Pietro, Butera Calogera, Guerriero Roberta, Cursi Marco, Leocani Letizia, Comi Giancarlo, Del Carro Ubaldo
Аннотация
BACKGROUND: Sensory tricks such as touching the face with fingertips often improve cervical dystonia [CD]. This study is to determine whether sensory tricks modulate motor cortex excitability, assessed by paired-pulse transcranial magnetic stimulation [p-pTMS].
METHODS: Eight patients with rotational CD underwent p-pTMS, at rest and when the sensory trick was applied. To test intracortical inhibition [ICI] and facilitation [ICF], the amplitude ratio between conditioned and unconditioned cortical motor evoked potentials was measured at several interstimulus intervals (ISI 1, 3, 15, and 20 ms) and compared with controls mimicking patients' sensory tricks.
RESULTS: At rest, a significant ICF enhancement was found at ISIs 15 through 20 in patients compared with controls, whereas no significant ICI changes were observed. Sensory tricks significantly reduced the abnormal ICF in patients and did not induce any change in controls.
CONCLUSIONS: In our CD patients, sensory tricks seem to improve dystonia through an inhibitory effect on motor cortex excitability.
METHODS: Eight patients with rotational CD underwent p-pTMS, at rest and when the sensory trick was applied. To test intracortical inhibition [ICI] and facilitation [ICF], the amplitude ratio between conditioned and unconditioned cortical motor evoked potentials was measured at several interstimulus intervals (ISI 1, 3, 15, and 20 ms) and compared with controls mimicking patients' sensory tricks.
RESULTS: At rest, a significant ICF enhancement was found at ISIs 15 through 20 in patients compared with controls, whereas no significant ICI changes were observed. Sensory tricks significantly reduced the abnormal ICF in patients and did not induce any change in controls.
CONCLUSIONS: In our CD patients, sensory tricks seem to improve dystonia through an inhibitory effect on motor cortex excitability.