Characteristics of subjective cognitive decline associated with amyloid positivity.
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Janssen Olin, Jansen Willemijn J, Vos Stephanie J B, Boada Merce, Parnetti Lucilla, Gabryelewicz Tomasz, Fladby Tormod, Molinuevo José Luis, Villeneuve Sylvia, Hort Jakub, Epelbaum Stéphane, Lleó Alberto, Engelborghs Sebastiaan, van der Flier Wiesje M, Landau Susan, Popp Julius, Wallin Anders, Scheltens Philip, Rikkert Marcel Olde, Snyder Peter J, Rowe Chris, Chételat Gaël, Ruíz Agustin, Marquié Marta, Chipi Elena, Wolfsgruber Steffen, Heneka Michael, Boecker Henning, Peters Oliver, Jarholm Jonas, Rami Lorena, Tort-Merino Adrià, Binette Alexa Pichet, Poirier Judes, Rosa-Neto Pedro, Cerman Jiri, Dubois Bruno, Teichmann Marc, Alcolea Daniel, Fortea Juan, Sánchez-Saudinós M Belén, Ebenau Jarith, Pocnet Cornelia, Eckerström Marie, Thompson Louisa, Villemagne Victor, Buckley Rachel, Burnham Samantha, Delarue Marion, Freund-Levi Yvonne, Wallin Åsa K, Ramakers Inez, Tsolaki Magda, Soininen Hilkka, Hampel Harald, Spiru Luiza, Alzheimer's Disease Neuroimaging Initiative, FACEHBI study group, PREVENT-AD research group, Tijms Betty, Ossenkoppele Rik, Verhey Frans R J, Jessen Frank, Visser Pieter Jelle
Аннотация
METHODS: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity.
RESULTS: Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages.
DISCUSSION: Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.