Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica · 2005
[Experimental study on treatment of minimal change nephropathy with Lespedeza michx].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Wang Cai-Yun, Deng Hong-Zhu, Li Hui
Аннотация
OBJECTIVE: To study the therapeutic effect of Lespedeza Michx in experimental rat model of minimal change nephropathy (MCN).
METHOD: The rat MCN model was reproduced by tail-intravenous injection of Adriamycin. The treatment effect of Lespedeza Michx was determined by the detection of urine protein collection for 24 hours, malondialdehyde (MDA), superoxide dismutase (SOD), ATCO, IL-8, TNF-alpha in serum, and renal histopathological changes were observed by microscope.
RESULT: Lespedeza Michx could decrease the contents of urine proteinuria, MDA, IL-8, and TNF-alpha in serum, increase SOD level and improved the pathological change of glomeruli.
CONCLUSION: Lespedeza Michx was effective on MCN.
METHOD: The rat MCN model was reproduced by tail-intravenous injection of Adriamycin. The treatment effect of Lespedeza Michx was determined by the detection of urine protein collection for 24 hours, malondialdehyde (MDA), superoxide dismutase (SOD), ATCO, IL-8, TNF-alpha in serum, and renal histopathological changes were observed by microscope.
RESULT: Lespedeza Michx could decrease the contents of urine proteinuria, MDA, IL-8, and TNF-alpha in serum, increase SOD level and improved the pathological change of glomeruli.
CONCLUSION: Lespedeza Michx was effective on MCN.