Effects of (+)-cyanidanol-3 on chronic liver injury.

Thirty patients of both sexes, suffering from alcoholic or diabetic liver injury, were studied in order to establish therapeutic effects of daily 3000 mg (+)-cyanidanol-3 administered for 3 weeks. In addition to subjective complaints, alterations in liver-specific enzyme-levels, changes in serumlipoids, the BSP half-time, activity of the microsomal enzyme-system and changes in the diabetic metabolism were studied. During the observation significant improvement of the disturbed enzyme-activities, decrease of the high lipoid level, reduction of the BSP half-time and the increasing activity of the microsomal enzyme-system could be proved. In case of diabetic patients a favourable change of the metabolic status could be established. Subjective complaints of patients subsided. In case of 17 patients the radionuclide HIDA method was applied too in order to study the dynamics of bile-transport. A moderately significant acceleration of the bile-transport could be observed. While continuing the treatment of 15 patients for 6 months, a control liver biopsy was carried out and in 10 cases it revealed favourable changes in the histological finding. During cyanidanol treatment gastrointestinal intolerance was observed in two patients, but only temporarily. Immune haemolysis did not occur.