Multiple sclerosis (Houndmills, Basingstoke, England) · 2025
Reduced brain volumes in children with radiologically isolated syndrome.
СтатьяНазвание и аннотация: Перевод в очереди
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Koukou Georgia, Bartels Frederik, Aigner Annette, Cleaveland Robert, Tuncer Anastasia, Wendel Eva-Maria, Bertolini Annikki, Wassmer Evangeline, Kornek Barbara, Schimmel Mareike, Panzer Andreas, Finke Carsten, Rostásy Kevin
Аннотация
BACKGROUND: Pediatric multiple sclerosis (MS) is associated with reduced brain volumes at first episode compared to healthy controls.
OBJECTIVE: To assess brain volumes in children fulfilling the criteria of radiologically isolated syndrome (RIS) at onset and over time.
METHODS: Clinical course, laboratory findings, MR-imaging in pediatric RIS were compared to controls from the NIH Pediatric MRI Data Repository and a cohort of patients with pediatric MS.
RESULTS: 20 RIS and 37 MS patients were included in the study. Median age at RIS diagnosis was 13.1 years (IQR: 10.3, 14.8) and whole brain volume was reduced by 77 cm3, compared to matched healthy controls (1673 cm3 (1637, 1728) vs 1750 cm3 (1699, 1802)). Nine RIS patients developed MS (RIS-to-MS) at a median age of 15.8 years (12.7,17.0). Longitudinal volumetry revealed lower brain volume in both non-converting and converting RIS patients compared to controls, similar to the trajectory in pediatric MS (RIS -4.7% (-6.5, -2.9), RIS-to-MS -5.1% (-6.9, -3.4), MS -6.6 % (-7.6, -5.5)). Oligoclonal bands, cerebrospinal fluid (CSF) pleocytosis, and reduced brain volume in RIS at diagnosis increased hazards of conversion to MS.
CONCLUSIONS: Reduced whole brain volume is already present in pediatric radiologically isolated syndrome (RIS). Longitudinal analysis of RIS patients revealed reduced brain volume over time, similar to MS.
OBJECTIVE: To assess brain volumes in children fulfilling the criteria of radiologically isolated syndrome (RIS) at onset and over time.
METHODS: Clinical course, laboratory findings, MR-imaging in pediatric RIS were compared to controls from the NIH Pediatric MRI Data Repository and a cohort of patients with pediatric MS.
RESULTS: 20 RIS and 37 MS patients were included in the study. Median age at RIS diagnosis was 13.1 years (IQR: 10.3, 14.8) and whole brain volume was reduced by 77 cm3, compared to matched healthy controls (1673 cm3 (1637, 1728) vs 1750 cm3 (1699, 1802)). Nine RIS patients developed MS (RIS-to-MS) at a median age of 15.8 years (12.7,17.0). Longitudinal volumetry revealed lower brain volume in both non-converting and converting RIS patients compared to controls, similar to the trajectory in pediatric MS (RIS -4.7% (-6.5, -2.9), RIS-to-MS -5.1% (-6.9, -3.4), MS -6.6 % (-7.6, -5.5)). Oligoclonal bands, cerebrospinal fluid (CSF) pleocytosis, and reduced brain volume in RIS at diagnosis increased hazards of conversion to MS.
CONCLUSIONS: Reduced whole brain volume is already present in pediatric radiologically isolated syndrome (RIS). Longitudinal analysis of RIS patients revealed reduced brain volume over time, similar to MS.