Brain & development · 2026
Incidence of brushes on electroencephalogram at 36 weeks of postmenstrual age in extremely and late preterm infants.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Maeda Takashi, Shiraki Anna, Takami Nao, Fujito Shota, Ueda Kazuto, Taniguchi Akinobu, Tanaka Ryuichi, Miura Ryosuke, Suzuki Toshihiko, Muramatsu Yukako, Kidokoro Hiroyuki, Sato Yoshiaki
Аннотация
OBJECTIVE: To compare the incidence and topographical distribution of brushes at 36 weeks postmenstrual age (PMA) between extremely preterm (EPI) and late preterm infants (LPI), and to clarify differences in cortical maturation.
METHODS: This retrospective observational study included 23 EPI (22-27 weeks' gestation) and 51 LPI (33-35 weeks' gestation) who underwent electroencephalography (EEG) between 35 and 36 weeks PMA. LPI were further subdivided into appropriate for gestational age (AGA, n = 42) and small for gestational age (SGA, n = 9). Brushes were visually identified in artifact-free segments of active sleep (AS) and quiet sleep (QS). Incidence was quantified as brushes per minute, and regional distributions were analyzed across frontal, central, temporal, and occipital leads.
RESULTS: The incidence of brushes was significantly higher in EPI than in LPI during both AS (median 10.0 vs 4.6/min, p < 0.001) and QS (7.8 vs 4.9/min, p = 0.004). Subgroup analysis revealed higher incidences in LPI-SGA than in LPI-AGA, and comparable levels between EPI and LPI-SGA. Topographically, EPI and LPI-SGA exhibited higher incidence in central and temporal regions compared with LPI-AGA. Inter-rater reliability for brush quantification was strong in AS and moderate in QS.
CONCLUSIONS: Higher incidence of brushes at 36 weeks PMA was more common in EPI and LPI-SGA, suggesting delayed cortical maturation in these vulnerable populations. The findings support the potential of brush persistence as an early EEG marker of cortical vulnerability.
METHODS: This retrospective observational study included 23 EPI (22-27 weeks' gestation) and 51 LPI (33-35 weeks' gestation) who underwent electroencephalography (EEG) between 35 and 36 weeks PMA. LPI were further subdivided into appropriate for gestational age (AGA, n = 42) and small for gestational age (SGA, n = 9). Brushes were visually identified in artifact-free segments of active sleep (AS) and quiet sleep (QS). Incidence was quantified as brushes per minute, and regional distributions were analyzed across frontal, central, temporal, and occipital leads.
RESULTS: The incidence of brushes was significantly higher in EPI than in LPI during both AS (median 10.0 vs 4.6/min, p < 0.001) and QS (7.8 vs 4.9/min, p = 0.004). Subgroup analysis revealed higher incidences in LPI-SGA than in LPI-AGA, and comparable levels between EPI and LPI-SGA. Topographically, EPI and LPI-SGA exhibited higher incidence in central and temporal regions compared with LPI-AGA. Inter-rater reliability for brush quantification was strong in AS and moderate in QS.
CONCLUSIONS: Higher incidence of brushes at 36 weeks PMA was more common in EPI and LPI-SGA, suggesting delayed cortical maturation in these vulnerable populations. The findings support the potential of brush persistence as an early EEG marker of cortical vulnerability.