Frontiers in endocrinology · 2026
Glucagon-stimulated copeptin response in children: a proof-of-concept study.
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Indirli Rita, Giacchetti Federico, Profka Eriselda, Rodari Giulia, Petria Iulia, Arosio Maura, Giavoli Claudia, Mantovani Giovanna, Ferrante Emanuele
Аннотация
PURPOSE: The diagnostic workup of polyuria-polydipsia syndrome (PPS) is not well-established in children and adolescents, and several non-osmotic copeptin-stimulating agents have been investigated. Glucagon stimulation test (GST) induced a robust copeptin response in adults, but data in children are lacking. This study aimed to investigate copeptin response to GST in children tested for suspected growth hormone (GH) deficiency.
METHODS: Twenty children (9 girls, age 10.3 ± 2.9 years) with no PPS underwent GST (30 µg/kg of glucagon i.m.). Plasma glucose, GH, cortisol, and copeptin were measured before and 60, 90, 120, 150, and 180 min after glucagon injection.
RESULTS: Median copeptin concentration was 4.1 pmol/L (IQR 3.3-6.7) at baseline and 10.6 pmol/L (5.4-17.9) at peak concentration (+87% at 150 min). No adverse events were recorded.
CONCLUSION: GST is safe and effective at enhancing copeptin secretion in children with intact neurohypophysial function, and further studies are warranted to assess its accuracy in the differential diagnosis of PPS.
METHODS: Twenty children (9 girls, age 10.3 ± 2.9 years) with no PPS underwent GST (30 µg/kg of glucagon i.m.). Plasma glucose, GH, cortisol, and copeptin were measured before and 60, 90, 120, 150, and 180 min after glucagon injection.
RESULTS: Median copeptin concentration was 4.1 pmol/L (IQR 3.3-6.7) at baseline and 10.6 pmol/L (5.4-17.9) at peak concentration (+87% at 150 min). No adverse events were recorded.
CONCLUSION: GST is safe and effective at enhancing copeptin secretion in children with intact neurohypophysial function, and further studies are warranted to assess its accuracy in the differential diagnosis of PPS.