Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
Wormian bones: expanded differential diagnosis and implications for abnormal head shape in infancy.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Alter Noah E, Rogers James L, Puc Marcelina, Hoang Anthony, Galdyn Izabela, Bonfield Christopher M, Pontell Matthew, Golinko Michael
Аннотация
PURPOSE: Wormian bones (WB) are accessory ossicles that develop within cranial sutures. While typically benign, their presence in large numbers has been associated with various genetic and developmental disorders. This study aims to characterize the prevalence, anatomical distribution, and clinical associations of WB in a pediatric population undergoing cranial CT imaging.
METHODS: A retrospective review was conducted at Monroe Carell Jr. Children's Hospital at Vanderbilt. Pediatric patients aged 0 to 18 years who underwent cranial CT imaging for any clinical indication were included. WB were radiologically confirmed, and demographic data, cephalic index, and comorbidities were collected and analyzed.
RESULTS: Among the 13,519 patients who underwent cranial CT imaging, 77 (0.57%) had radiologically confirmed WB, totaling 476 ossicles. The prevalence increased to 2.1% when examining our clinic cohort over a 5-year period. The lambdoid suture was the most common site (343/476, 72.1%), followed by the posterior fontanelle (53/476, 11.1%). Multiple WB (≥ 2) represented the most common phenotype (52/77, 67.5% of cases), and 13 patients (16.8%) had at least one associated skeletal or craniofacial condition, most commonly craniosynostosis (10/13, 76.9%). Cephalic index analysis demonstrated a predominance of brachycephaly (54/77, 70.1%).
CONCLUSION: This study presents a comprehensive evaluation of WB in a large pediatric cohort. WB may co-exist with craniosynostosis or other skeletal conditions such as osteogenesis imperfecta. Given the greater prevalence of WB compared to craniosynostosis (2.1%: clinic cohort & 0.57%: institutional cohort vs. 0.05%), clinicians should consider WB in the differential diagnosis of abnormal head shape in infancy, particularly in a subspecialist practice.
METHODS: A retrospective review was conducted at Monroe Carell Jr. Children's Hospital at Vanderbilt. Pediatric patients aged 0 to 18 years who underwent cranial CT imaging for any clinical indication were included. WB were radiologically confirmed, and demographic data, cephalic index, and comorbidities were collected and analyzed.
RESULTS: Among the 13,519 patients who underwent cranial CT imaging, 77 (0.57%) had radiologically confirmed WB, totaling 476 ossicles. The prevalence increased to 2.1% when examining our clinic cohort over a 5-year period. The lambdoid suture was the most common site (343/476, 72.1%), followed by the posterior fontanelle (53/476, 11.1%). Multiple WB (≥ 2) represented the most common phenotype (52/77, 67.5% of cases), and 13 patients (16.8%) had at least one associated skeletal or craniofacial condition, most commonly craniosynostosis (10/13, 76.9%). Cephalic index analysis demonstrated a predominance of brachycephaly (54/77, 70.1%).
CONCLUSION: This study presents a comprehensive evaluation of WB in a large pediatric cohort. WB may co-exist with craniosynostosis or other skeletal conditions such as osteogenesis imperfecta. Given the greater prevalence of WB compared to craniosynostosis (2.1%: clinic cohort & 0.57%: institutional cohort vs. 0.05%), clinicians should consider WB in the differential diagnosis of abnormal head shape in infancy, particularly in a subspecialist practice.