[Brain bioelectrical activity in patients with the fragile X-chromosome syndrome and in their mothers].

30 patients (4-22 years old) and their 12 mothers were examined by means of method of electroencephalography (EEG). Healthy individuals of corresponding age were included in the control group. EEG changes of the same type were observed in all the patients with syndrome of fragile X-chromosome: reduction of occipital alpha-rhythm, prevalence of theta-rhythm in central-parietal and central frontal regions as well as epileptoid activity in parietal and central-parietal cortical regions. These peculiarities could be considered as the markers in syndrome's diagnostics. EEG of mothers (heterozygous carriers of mutant gene) were characterised by considerable variations: increase of rolandic rhythm's presentation in central cortical zones, accumulation of hypersynchronous EEG, increase of rhythmical theta-activity, etc. EEG of mother with shift-like schizophrenia resembled one of proband in one case.