Effect of Tranexamic Acid Administration on the State of Pial Arterial Vessels in Rats with Acute Hemorrahage and Hypothermia.

Using in vivo microscopy, changes in the diameter of pial arterial microvessels were studied in rats with modeled moderate acute blood loss followed by whole-body cooling against the background of a single administration of tranexamic acid at a dose of 10 mg/kg. The antifibrinolytic agent enhanced vasoconstrictor responses of the arterioles during deep cooling, but had no significant effect at the stages of mild and moderate hypothermia.