Clinical neurology and neurosurgery · 2025
Focal areas of signal intensity in neurofibromatosis type 1: Correlation between MRI findings and cognitive function.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Distefano Chiara, Lo Bianco Manuela, Palmucci Stefano, Ruggieri Martino, Polizzi Agata, Praticò Andrea D
Аннотация
BACKGROUND: Focal areas of signal intensity (FASI) are T2-weighted hyperintensities detected on brain MRI in 43 %-93 % of children with neurofibromatosis type 1 (NF1). Their association with cognitive impairment, a common feature of NF1, remains controversial.
OBJECTIVE: To investigate potential correlations between the presence, number, and location of FASI and cognitive performance in children with NF1.
MATERIALS AND METHODS: Brain MRIs and neuropsychological reports of 17 patients with NF1 (mean age 9.29 ± 3.7 SD) were retrospectively reviewed. Cognitive profiles were assessed using standardized Wechsler scales (WPPSI-III, WISC-III, WAIS-R).
RESULTS: The mean Full Scale Intelligence Quotient (FSIQ) was 84 ± 14.54, within the borderline range; 11.76 % of patients had a diagnosis of Intellectual Disability (ID). A clinically significant discrepancy between Verbal and Performance Intelligence Quotient (PIQ) was observed in 64.7 % of patients, favoring PIQ. The mean number of FASI per patient was 3.94 ± 1.76. Pearson's correlation revealed a non-significant inverse association between total FASI count and FSIQ (r = -0.12, p = 0.621). The cerebellum was the most frequently affected region (70.6 %). Patients with FASI in the cerebellum or brainstem had significantly higher PIQ than those with FASI elsewhere (p < 0.05). The two patients with ID both had thalamic FASI.
CONCLUSIONS: This exploratory study suggests that FASI location and number may be associated with cognitive variability in NF1, but larger studies are needed to confirm these trends.
OBJECTIVE: To investigate potential correlations between the presence, number, and location of FASI and cognitive performance in children with NF1.
MATERIALS AND METHODS: Brain MRIs and neuropsychological reports of 17 patients with NF1 (mean age 9.29 ± 3.7 SD) were retrospectively reviewed. Cognitive profiles were assessed using standardized Wechsler scales (WPPSI-III, WISC-III, WAIS-R).
RESULTS: The mean Full Scale Intelligence Quotient (FSIQ) was 84 ± 14.54, within the borderline range; 11.76 % of patients had a diagnosis of Intellectual Disability (ID). A clinically significant discrepancy between Verbal and Performance Intelligence Quotient (PIQ) was observed in 64.7 % of patients, favoring PIQ. The mean number of FASI per patient was 3.94 ± 1.76. Pearson's correlation revealed a non-significant inverse association between total FASI count and FSIQ (r = -0.12, p = 0.621). The cerebellum was the most frequently affected region (70.6 %). Patients with FASI in the cerebellum or brainstem had significantly higher PIQ than those with FASI elsewhere (p < 0.05). The two patients with ID both had thalamic FASI.
CONCLUSIONS: This exploratory study suggests that FASI location and number may be associated with cognitive variability in NF1, but larger studies are needed to confirm these trends.