Brain research bulletin · 2025
Articulation-function-associated brain developmental changes in cleft lip and palate patients.
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Zhang Wenjing, Guan Zhongtian, Cao Lei, Sun Liwei, Zhang Xu, Chen Renji, Li Chunlin, Song Weiqun
Аннотация
BACKGROUND: Cleft palate articulation disorder is the most common dysfunction in individuals with cleft lip and palate (CLP), significantly affecting communication and quality of life. Despite previous studies having examined structural and functional brain changes in CLP, age-related functional changes related to articulation disorders remain unclear.
OBJECTIVE: The purpose of this research was to investigate brain functional differences across age groups of CLP patients and correlations with articulation performance.
METHOD: A total of 127 participants were included: 25 CLP children, 34 healthy children, 44 CLP adults, and 24 healthy adults. Resting-state functional magnetic resonance imaging (fMRI) was used to assess brain activity. Voxel-based analysis, functional connectivity, and network topological properties were assessed, along with mediation analysis to explore relationships between age, brain function, and articulation performance.
RESULTS: CLP adults and children showed significant differences in resting-state brain function, particularly in the cerebellar vermis, crus, right parietal lobe, temporal lobe, and right central region-key areas for semantic processing and motor control. CLP adults exhibited greater connectivity between the postcentral gyrus and cerebellar vermis and enhanced small-world properties. Mediation analysis indicated that regional homogeneity in the left medial superior frontal cortex fully mediated the relationship between articulation performance and age.
CONCLUSION: CLP patients with articulation disorders exhibited altered brain functional synchronization as compared to controls, with adults showing further network development. Differences between children and adults highlight variations in treatment focus and stability, and this highlights the necessity of age-specific rehabilitation protocols.
OBJECTIVE: The purpose of this research was to investigate brain functional differences across age groups of CLP patients and correlations with articulation performance.
METHOD: A total of 127 participants were included: 25 CLP children, 34 healthy children, 44 CLP adults, and 24 healthy adults. Resting-state functional magnetic resonance imaging (fMRI) was used to assess brain activity. Voxel-based analysis, functional connectivity, and network topological properties were assessed, along with mediation analysis to explore relationships between age, brain function, and articulation performance.
RESULTS: CLP adults and children showed significant differences in resting-state brain function, particularly in the cerebellar vermis, crus, right parietal lobe, temporal lobe, and right central region-key areas for semantic processing and motor control. CLP adults exhibited greater connectivity between the postcentral gyrus and cerebellar vermis and enhanced small-world properties. Mediation analysis indicated that regional homogeneity in the left medial superior frontal cortex fully mediated the relationship between articulation performance and age.
CONCLUSION: CLP patients with articulation disorders exhibited altered brain functional synchronization as compared to controls, with adults showing further network development. Differences between children and adults highlight variations in treatment focus and stability, and this highlights the necessity of age-specific rehabilitation protocols.