AJNR. American journal of neuroradiology · 1994
Cerebral MR in ophthalmoplegia plus.
СтатьяНазвание и аннотация: Перевод в очереди
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Leutner C, Layer G, Zierz S, Solymosi L, Dewes W, Reiser M
Аннотация
PURPOSE: To evaluate MR patterns in ophthalmoplegia plus and correlate them with clinical symptoms.
METHODS: MR was performed on a 1.5-T whole-body scanner with T2-weighted gradient-echo and spin-echo images. The retrospective analysis included 19 patients with clinically established diagnoses of ophthalmoplegia plus.
RESULTS: Two types of cerebral MR abnormalities were found in ophthalmoplegia plus: brain atrophy and hyperintensities restricted to the white matter and basal ganglia, which appeared as either focal or diffuse areas of high signal intensity and were of strictly supratentorial location. No specific distribution was found. These findings differ markedly from infarction-like lesions found in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.
CONCLUSIONS: MR is sensitive for the detection of central nervous system involvement in ophthalmoplegia plus, but findings are nonspecific. However, cerebral MR in ophthalmoplegia plus is different from other mitochondrial encephalomyopathies and underlines the clinical differentiation of mitochondrial encephalomyopathies.
METHODS: MR was performed on a 1.5-T whole-body scanner with T2-weighted gradient-echo and spin-echo images. The retrospective analysis included 19 patients with clinically established diagnoses of ophthalmoplegia plus.
RESULTS: Two types of cerebral MR abnormalities were found in ophthalmoplegia plus: brain atrophy and hyperintensities restricted to the white matter and basal ganglia, which appeared as either focal or diffuse areas of high signal intensity and were of strictly supratentorial location. No specific distribution was found. These findings differ markedly from infarction-like lesions found in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.
CONCLUSIONS: MR is sensitive for the detection of central nervous system involvement in ophthalmoplegia plus, but findings are nonspecific. However, cerebral MR in ophthalmoplegia plus is different from other mitochondrial encephalomyopathies and underlines the clinical differentiation of mitochondrial encephalomyopathies.
Предметные рубрики MeSH
AdolescentAdultAtrophyBrainBrain DiseasesCerebellar DiseasesDementiaDiagnosis, DifferentialFemaleHumansKearns-Sayre SyndromeMagnetic Resonance ImagingMaleMiddle AgedMitochondrial EncephalomyopathiesMuscular DiseasesOphthalmoplegia, Chronic Progressive ExternalParesisPyramidal TractsRetrospective StudiesSpinal Cord Diseases