Developmental cell · 2022
Temporal molecular program of human hematopoietic stem and progenitor cells after birth.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Zhang Yawen, Xie Xiaowei, Huang Yaojing, Liu Mengyao, Li Qiaochuan, Luo Jianming, He Yunyan, Yin Xiuxiu, Ma Shihui, Cao Wenbin, Chen Shulian, Peng Jun, Guo Jiaojiao, Zhou Wen, Luo Hongbo, Dong Fang, Cheng Hui, Hao Sha, Hu Linping, Zhu Ping, Cheng Tao
Аннотация
Hematopoietic stem and progenitor cells (HSPCs) give rise to the blood system and maintain hematopoiesis throughout the human lifespan. Here, we report a transcriptional census of human bone-marrow-derived HSPCs from the neonate, infant, child, adult, and aging stages, showing two subpopulations of multipotent progenitors separated by CD52 expression. From birth to the adult stage, stem and multipotent progenitors shared similar transcriptional alterations, and erythroid potential was enhanced after the infant stage. By integrating transcriptome, chromatin accessibility, and functional data, we further showed that aging hematopoietic stem cells (HSCs) exhibited a bias toward megakaryocytic differentiation. Finally, in comparison with the HSCs from the cord blood, neonate bone-marrow-derived HSCs were more quiescent and had higher long-term regeneration capability and durable self-renewal. Taken together, this work provides an integral transcriptome landscape of HSPCs and identifies their dynamics in post-natal steady-state hemopoiesis, thereby helping explore hematopoiesis in development and diseases.