Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2025
[Association of left atrial dilation with the thickening of the intima-media complex of the common carotid artery and risk factors for cerebrovascular complications in patients with comorbidities].
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Murkamilov I T, Aitbaev K A, Fomin V V, Shchendrigin I N, Rayimzhanov Z R, Abdurakhmanov I U, Yusupov F A, Yusupova Z F, Yusupova T F, Abdykadyrov M Sh
Аннотация
OBJECTIVE: To assess the relationship between the left atrial dilation and the thickening of the intima-media complex of the common carotid artery and the risk factors for cerebrovascular complications in patients with comorbidities.
MATERIAL AND METHODS: The study included 254 patients (150 males and 104 females) with comorbidities. Participants were assessed for risk factors for cerebrovascular complications, the thickness of the intima-media complex of the common carotid artery, and the size of the left atrium, considering gender.
RESULTS: In males and females with comorbidities, the most common risk factors for cerebrovascular complications were overweight (33.3% and 25.0%), grade I obesity (32.0% and 37.5%), hypertension (76.0% and 69.2%), tachycardia (52.6% and 51.9%), anemia (46.6% and 33.6%), hypercholesterolemia (36.0% and 36.5%), hypertriglyceridemia (34.6% and 20.1%), dyslipidemia (50.6% and 59.6%), elevated C-reactive protein (32.0% and 34.6%), chronic renal failure (34.6% and 28.8%), increased intima-media thickness of the common carotid artery (69.3% and 62.5%). The linear dimension (2.37±0.31 cm) and indexed volume of the left atrium (45±0.06 mL/m²) in males were significantly higher than in females (2.26±0.30 cm/43±0.05 mL/m²). Correlations were established between the linear size of the left atrium and body mass index (r=0.362), levels of systolic (r=0.159) and diastolic (r=0.150) blood pressure, total cholesterol levels (r=0.204), low-density lipoprotein cholesterol (r=0.221), triglycerides (r=0.746), high-density lipoprotein cholesterol (r=0.721), C-reactive protein (r=0.595) and thickness of the intima-media complex of the common carotid artery (r=0.143). A significant positive relationship was found between the thickness of the intima-media complex of the common carotid artery and the indexed volume of the left atrium (r=0.197) and a negative relationship between the glomerular filtration rate and the left atrial linear size (r=-0.167).
CONCLUSION: A high prevalence of risk factors for cerebrovascular complications has been identified in patients with comorbidities. The study's results suggest that dilation of the left atrium plays a significant role in developing cerebrovascular complications.
MATERIAL AND METHODS: The study included 254 patients (150 males and 104 females) with comorbidities. Participants were assessed for risk factors for cerebrovascular complications, the thickness of the intima-media complex of the common carotid artery, and the size of the left atrium, considering gender.
RESULTS: In males and females with comorbidities, the most common risk factors for cerebrovascular complications were overweight (33.3% and 25.0%), grade I obesity (32.0% and 37.5%), hypertension (76.0% and 69.2%), tachycardia (52.6% and 51.9%), anemia (46.6% and 33.6%), hypercholesterolemia (36.0% and 36.5%), hypertriglyceridemia (34.6% and 20.1%), dyslipidemia (50.6% and 59.6%), elevated C-reactive protein (32.0% and 34.6%), chronic renal failure (34.6% and 28.8%), increased intima-media thickness of the common carotid artery (69.3% and 62.5%). The linear dimension (2.37±0.31 cm) and indexed volume of the left atrium (45±0.06 mL/m²) in males were significantly higher than in females (2.26±0.30 cm/43±0.05 mL/m²). Correlations were established between the linear size of the left atrium and body mass index (r=0.362), levels of systolic (r=0.159) and diastolic (r=0.150) blood pressure, total cholesterol levels (r=0.204), low-density lipoprotein cholesterol (r=0.221), triglycerides (r=0.746), high-density lipoprotein cholesterol (r=0.721), C-reactive protein (r=0.595) and thickness of the intima-media complex of the common carotid artery (r=0.143). A significant positive relationship was found between the thickness of the intima-media complex of the common carotid artery and the indexed volume of the left atrium (r=0.197) and a negative relationship between the glomerular filtration rate and the left atrial linear size (r=-0.167).
CONCLUSION: A high prevalence of risk factors for cerebrovascular complications has been identified in patients with comorbidities. The study's results suggest that dilation of the left atrium plays a significant role in developing cerebrovascular complications.