Efficacy of combining soothing moisturizing repairing cream with glucocorticoids in the treatment of moderate atopic dermatitis in pediatric patients: A prospective observational cohort study.

Glucocorticoids are the most commonly used drugs for the treatment of atopic dermatitis (AD) in children, this study aimed to explore the therapeutic efficacy of combining moisturizers and glucocorticoids in the treatment of moderate AD in pediatric patients. Patients aged 6 to 12 years with moderate AD were involved. The control group received fluticasone propionate cream twice daily, and the experimental group received soothing moisturizing repairing cream combined to the fluticasone. Both groups treated continuously for most 4 weeks until the Symptom Score Reduction Index ≥90% and then entered a 2-week remission phase. Clinical outcomes, fluticasone dosage, Children's Dermatology Life Quality Index, AD recurrence rates, remission duration, and adverse events were compared at the end of the remission period. A total of 54 patients completed the follow-up, with 25 in the control and 29 in the experimental group. The overall clinical efficiency in the experimental group (100%, 95% confidence interval: 88.1-100.0%) was significantly higher than in the control group (84%, 95% confidence interval: 63.9-95.5%) with P = .040. Both groups showed a decrease in Children's Dermatology Life Quality Index. The recurrence rate was remarkably lower, and the remission duration was longer in the experimental group (both P < .05). Combining soothing moisturizing repairing cream with fluticasone cream has good clinical efficacy in the treatment of moderate AD in children. This combination therapy can effectively reduce the risk of relapses during the remission period, improve clinical symptoms, and improve quality of life in children with AD.