Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2007
Change in cerebral autoregulation as a function of time in children after severe traumatic brain injury: a case series.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Tontisirin Nuj, Armstead William, Waitayawinyu Pichaya, Moore Anne, Udomphorn Yuthana, Zimmerman Jerry J, Chesnut Randall, Vavilala Monica S
Аннотация
OBJECTIVE: The objective of this study was to describe changes in cerebral autoregulation after severe pediatric traumatic brain injury (TBI).
MATERIALS AND METHODS: Two cerebral autoregulation tests were performed during the first 10 days after severe TBI in children <16 years. Cerebral autoregulation was quantified using the mean autoregulatory index (mARI).
RESULTS: Nine (five males/four females) children (10 +/- 5 years) with severe (admission Glasgow Coma Scale (GCS), 5 +/- 2) TBI were enrolled. Thirty (3/9) percent of initial exams revealed impaired cerebral autoregulation; all three had returned to intact cerebral autoregulation on second exam. However, in three of nine (33%) patients, cerebral autoregulation worsened on second exam. Of the factors examined, worsening mARI on second exam was associated with worsening head computed tomography (CT) lesion.
CONCLUSIONS: Cerebral autoregulation often changed and worsened during the first 9 days after severe pediatric TBI. Worsening cerebral autoregulation may mirror worsening TBI.
MATERIALS AND METHODS: Two cerebral autoregulation tests were performed during the first 10 days after severe TBI in children <16 years. Cerebral autoregulation was quantified using the mean autoregulatory index (mARI).
RESULTS: Nine (five males/four females) children (10 +/- 5 years) with severe (admission Glasgow Coma Scale (GCS), 5 +/- 2) TBI were enrolled. Thirty (3/9) percent of initial exams revealed impaired cerebral autoregulation; all three had returned to intact cerebral autoregulation on second exam. However, in three of nine (33%) patients, cerebral autoregulation worsened on second exam. Of the factors examined, worsening mARI on second exam was associated with worsening head computed tomography (CT) lesion.
CONCLUSIONS: Cerebral autoregulation often changed and worsened during the first 9 days after severe pediatric TBI. Worsening cerebral autoregulation may mirror worsening TBI.