Journal of clinical and experimental hematopathology : JCEH · 2025
ALK-negative anaplastic large cell lymphoma with TP53 mutation developing during the administration of baricitinib for atopic dermatitis - A case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Kawai Hidetsugu, Iwata Shino, Shiraiwa Sawako, Miyaoka Masashi, Ogiya Daisuke, Toyosaki Masako, Machida Shinichiro, Suzuki Rikio, Onizuka Makoto, Ogawa Yoshiaki, Nakamura Naoya, Kawada Hiroshi
Аннотация
Severe atopic dermatitis (AD) is known to be associated with a risk of lymphoma. We herein report a case of ALK-negative anaplastic large cell lymphoma (ALK-ALCL) complicated by severe AD during treatment with baricitinib, which is an oral, selective, and reversible Janus Kinase (JAK) 1 and 2 inhibitor used in the treatment of AD. Next-generation sequencing (NGS) demonstrated the TP53 p.G266E mutation, suggesting that this was the trigger of the disease and the cause of its refractory course. The JAK/signal transducer and activator of transcription (STAT) pathway is often activated in tumor cells of ALCLs, suggesting that it is a therapeutic target. The causal connection between baricitinib and lymphomagenesis remains unknown; however, this patient developed ALK-ALCL with TP53 mutations during baricitinib treatment.