Pharmacological research · 2021
Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development.
СтатьяПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод в очереди
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Lionetti Vincenzo, Bollini Sveva, Coppini Raffaele, Gerbino Andrea, Ghigo Alessandra, Iaccarino Guido, Madonna Rosalinda, Mangiacapra Fabio, Miragoli Michele, Moccia Francesco, Munaron Luca, Pagliaro Pasquale, Parenti Astrid, Pasqua Teresa, Penna Claudia, Quaini Federico, Rocca Carmine, Samaja Michele, Sartiani Laura, Soda Teresa, Tocchetti Carlo Gabriele, Angelone Tommaso
Аннотация
In-depth characterization of heart-brain communication in critically ill patients with severe acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 (COVID-19) pandemic era during intensive care unit (ICU) stay and after ICU or hospital discharge. Emerging research has provided new insights into pathogenic role of the deregulation of the heart-brain axis (HBA), a bidirectional flow of information, in leading to severe multiorgan disease syndrome (MODS) in patients with confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Noteworthy, HBA dysfunction may worsen the outcome of the COVID-19 patients. In this review, we discuss the critical role HBA plays in both promoting and limiting MODS in COVID-19. We also highlight the role of HBA as new target for novel therapeutic strategies in COVID-19 in order to open new translational frontiers of care. This is a translational perspective from the Italian Society of Cardiovascular Researches.