South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 1995
HPV typing of vulvovaginal condylomata in children.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Wright C A, Taylor L, Cooper K
Аннотация
OBJECTIVE: To determine the human papillomavirus (HPV) subtypes in vulvovaginal warts in prepubescent children.
DESIGN: Histopathology case series.
SETTING: Outpatient and gynaecology clinics of hospitals in the greater Johannesburg area.
PATIENTS: All cases of vulvovaginal warts diagnosed in children under the age of 12 years received at the South African Institute for Medical Research, Johannesburg, during the period 1 January 1991 to 31 December 1993.
MAIN OUTCOME MEASURES: Positivity for "genital' HPV types 6, 11, 16, 18, 31, 33 and 35 using non-isotopic in situ hybridisation (NISH) and polymerase chain reaction (PCR).
RESULTS: Eight of the 9 vulvovaginal warts contained HPV 11 when assessed by means of NISH (89%). PCR amplified HPV DNA in all 9 (100%) of the biopsies.
CONCLUSION: Detection of genital subtypes of HPV in childhood condylomata acuminata points strongly to sexual abuse, but should only be used as a guide to further investigation by a multidisciplinary team.
DESIGN: Histopathology case series.
SETTING: Outpatient and gynaecology clinics of hospitals in the greater Johannesburg area.
PATIENTS: All cases of vulvovaginal warts diagnosed in children under the age of 12 years received at the South African Institute for Medical Research, Johannesburg, during the period 1 January 1991 to 31 December 1993.
MAIN OUTCOME MEASURES: Positivity for "genital' HPV types 6, 11, 16, 18, 31, 33 and 35 using non-isotopic in situ hybridisation (NISH) and polymerase chain reaction (PCR).
RESULTS: Eight of the 9 vulvovaginal warts contained HPV 11 when assessed by means of NISH (89%). PCR amplified HPV DNA in all 9 (100%) of the biopsies.
CONCLUSION: Detection of genital subtypes of HPV in childhood condylomata acuminata points strongly to sexual abuse, but should only be used as a guide to further investigation by a multidisciplinary team.