Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025
Clinical Frailty Scale predicts overall survival after colon cancer surgery in people aged 80 years and older: A prospective multicentre observational study.
СтатьяНаблюдательное исследованиеМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Niemeläinen Susanna, Hyöty Marja, Ehrlich Anu, Jämsen Esa, Koskensalo Selja, Kössi Jyrki, Pinta Tarja, Vihervaara Hanna, Huhtala Heini
Аннотация
AIM: An increasing number of elective colon cancer surgeries are performed on older patients. Frail patients are at a higher risk of postoperative adverse events and early mortality. This prospective, multicentre, observational study aimed to analyse preoperative screening tools and the long-term survival of older patients having elective colon cancer surgery. The focus was on patients who survived more than 3 months postoperatively, excluding the effect of early postoperative mortality.
METHODS: Patients aged ≥80 years with electively operated stage I-III colon cancer were recruited. Prospectively collected data included comorbidities, functional and frailty status, postoperative outcomesand long-term survival. Univariate and multivariable Cox regression analyses were conducted to determine factors associated with long-term survival.
RESULTS: A total of 227 surgical patients were included. Survival rates at 1 and 3 years were 94% and 74% for all patients and 86% and 57% for patients with Clinical Frailty Scale (CFS) 5-9, respectively. In multivariable regression analysis, CFS 5-9 (HR 3.16, 95% CI 1.31-7.63, p = 0.011) and tumour stage III (HR 2.50, 1.16-5.39, p = 0.020) were the patient-related variables affecting survival among those surviving over 3 months postoperatively.
CONCLUSIONS: Preoperative frailty assessed by CFS predicts long-term survival in older patients after curative colon cancer surgery.
METHODS: Patients aged ≥80 years with electively operated stage I-III colon cancer were recruited. Prospectively collected data included comorbidities, functional and frailty status, postoperative outcomesand long-term survival. Univariate and multivariable Cox regression analyses were conducted to determine factors associated with long-term survival.
RESULTS: A total of 227 surgical patients were included. Survival rates at 1 and 3 years were 94% and 74% for all patients and 86% and 57% for patients with Clinical Frailty Scale (CFS) 5-9, respectively. In multivariable regression analysis, CFS 5-9 (HR 3.16, 95% CI 1.31-7.63, p = 0.011) and tumour stage III (HR 2.50, 1.16-5.39, p = 0.020) were the patient-related variables affecting survival among those surviving over 3 months postoperatively.
CONCLUSIONS: Preoperative frailty assessed by CFS predicts long-term survival in older patients after curative colon cancer surgery.