Journal of acquired immune deficiency syndromes (1999) · 2026
Proviral HIV-1 DNA Below Detection in Early Treated Adolescents After Previous Treatment Interruption.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Reddy Kavidha, Kuhn Louise, Barnabas Shaun, Molechan Chantal, Otwombe Kennedy, Jupimai Thidarat, Rutebarika Diana A, Nhampossa Tacilta, Lain Maria G, Archary Moherndran, Maiga Almoustapha I, Violari Avy, Spyer Moira, Barrios-Tascon Ana, Houvessou Gbenankpon M, Peay Holly L, Pahwa Savita, Palma Paolo, Lichterfeld Mathias, Cotton Mark F, Ndung'u Thumbi, CARMA-Global Study Team of the EPIICAL Consortium
Аннотация
BACKGROUND: Low and undetectable HIV-1 DNA levels are associated with greater likelihood of ART-free viral control and may help select candidates for analytic treatment interruption. We investigated predictors of HIV-1 DNA levels in older children and adolescents with perinatally acquired HIV who started ART early in life.
METHODS: Children older than 7 years and adolescents on ART and virally suppressed (<50 copies/mL) who started ART <3 months of age were recruited at sites in South Africa, Mozambique, Uganda, Mali, and Thailand. Previous viral rebound or ART interruption was allowed. HIV-1 DNA was measured in peripheral blood mononuclear cells using droplet-digital PCR. Associations between DNA levels and clinical factors were analyzed using descriptive statistics and χ 2 tests.
RESULTS: Among 89 participants (50.6% female), ART started at a median age of 66 days (IQR: 53-87) and current median age was 12.8 years (IQR: 9.6-16.7). Median HIV-1 DNA was 355 copies/10 6 cells (IQR: 151-912); 10.1% were undetectable (<1 copy/10 6 cells). Undetectable results were more frequent in those with ART interruption (21.7%) than continuous ART (6.1%), P = 0.0485. This was significant only in females (regardless of ART start age) and only in those who started ART < 60 days of age (regardless of sex).
CONCLUSIONS: About 10% of early-treated children and adolescents suppressed on ART had HIV-1 DNA levels below the assay's detection threshold. Previous ART interruption was associated with a greater likelihood of undetectable HIV-1 DNA. These results provide support for the concept of "auto-immunization," where ART interruption may, in certain circumstances, enhance HIV immunity and promote ART-free control.
METHODS: Children older than 7 years and adolescents on ART and virally suppressed (<50 copies/mL) who started ART <3 months of age were recruited at sites in South Africa, Mozambique, Uganda, Mali, and Thailand. Previous viral rebound or ART interruption was allowed. HIV-1 DNA was measured in peripheral blood mononuclear cells using droplet-digital PCR. Associations between DNA levels and clinical factors were analyzed using descriptive statistics and χ 2 tests.
RESULTS: Among 89 participants (50.6% female), ART started at a median age of 66 days (IQR: 53-87) and current median age was 12.8 years (IQR: 9.6-16.7). Median HIV-1 DNA was 355 copies/10 6 cells (IQR: 151-912); 10.1% were undetectable (<1 copy/10 6 cells). Undetectable results were more frequent in those with ART interruption (21.7%) than continuous ART (6.1%), P = 0.0485. This was significant only in females (regardless of ART start age) and only in those who started ART < 60 days of age (regardless of sex).
CONCLUSIONS: About 10% of early-treated children and adolescents suppressed on ART had HIV-1 DNA levels below the assay's detection threshold. Previous ART interruption was associated with a greater likelihood of undetectable HIV-1 DNA. These results provide support for the concept of "auto-immunization," where ART interruption may, in certain circumstances, enhance HIV immunity and promote ART-free control.