Journal of neuroinflammation · 2018
Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Coughlin Jennifer M, Yang Ting, Rebman Alison W, Bechtold Kathleen T, Du Yong, Mathews William B, Lesniak Wojciech G, Mihm Erica A, Frey Sarah M, Marshall Erica S, Rosenthal Hailey B, Reekie Tristan A, Kassiou Michael, Dannals Robert F, Soloski Mark J, Aucott John N, Pomper Martin G
Аннотация
The pathophysiology of post-treatment Lyme disease syndrome (PTLDS) may be linked to overactive immunity including aberrant activity of the brain's resident immune cells, microglia. Here we used [11C]DPA-713 and positron emission tomography to quantify the 18 kDa translocator protein, a marker of activated microglia or reactive astrocytes, in the brains of patients with post-treatment Lyme disease symptoms of any duration compared to healthy controls. Genotyping for the TSPO rs6971 polymorphism was completed, and individuals with the rare, low affinity binding genotype were excluded. Data from eight brain regions demonstrated higher [11C]DPA-713 binding in 12 patients relative to 19 controls. [11C]DPA-713 PET is a promising tool to study cerebral glial activation in PTLDS and its link to cognitive symptoms.
Предметные рубрики MeSH
AcetamidesAdolescentAdultAgedApoptosis Regulatory ProteinsBrainCarbon RadioisotopesCognition DisordersFemaleHumansImage Processing, Computer-AssistedLyme NeuroborreliosisMagnetic Resonance ImagingMaleMembrane ProteinsMiddle AgedNeuropsychological TestsPilot ProjectsPolymorphism, GeneticPositron-Emission TomographyPyrazolesPyrimidinesSeverity of Illness IndexYoung Adult