Revista brasileira de enfermagem · 2026
Effect of antioxidants derived from Copaifera langsdorffii Desf. on skin tissue repair in diabetic rats.
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Fernandes Maria Neyze Martins, Saraiva Andreza Gysllaynny Delmondes, Caldas Nathylle Régia de Sousa, Coelho Hercules Pereira, Lopes Maria do Socorro Vieira, Abreu Rita Neuma Dantas Cavalcante de, Pinheiro Woneska Rodrigues, Sampaio Luis Rafael Leite
Аннотация
OBJECTIVES: to assess the antioxidant effect of topically applied oleoresin from Copaifera langsdorffii Desf. on skin lesions in alloxan-induced diabetic rats.
METHODS: experiments were conducted on 200-300-gram adult male Wistar rats induced with diabetes by aloxan. A 7-millimeter metal punch was used for surgical circular epidermal excision. Animals were divided into five groups of five and treated with saline solution, mineral oil, 10% copaiba oil, essential fatty acids, or absolute copaiba oleoresin for one, seven, or 14 days. Malondialdehyde (MDA), nitrite, and glutathione (GSH) peroxidase concentrations were assessed to investigate oxidative activity progression. Tests were performed on animals approved by CEUA-URCA.
RESULTS: Copaifera langsdorffii Desf significantly reduced MDA and nitrite while increasing GSH. Groups treated with oleoresin, both 10% and absolute, improved assessed parameters.
CONCLUSIONS: these results suggest that Copaifera langsdorffii Desf. oleoresin has antioxidant activity and may protect against oxidative stress in skin lesions of aloxan-induced diabetic rats.
METHODS: experiments were conducted on 200-300-gram adult male Wistar rats induced with diabetes by aloxan. A 7-millimeter metal punch was used for surgical circular epidermal excision. Animals were divided into five groups of five and treated with saline solution, mineral oil, 10% copaiba oil, essential fatty acids, or absolute copaiba oleoresin for one, seven, or 14 days. Malondialdehyde (MDA), nitrite, and glutathione (GSH) peroxidase concentrations were assessed to investigate oxidative activity progression. Tests were performed on animals approved by CEUA-URCA.
RESULTS: Copaifera langsdorffii Desf significantly reduced MDA and nitrite while increasing GSH. Groups treated with oleoresin, both 10% and absolute, improved assessed parameters.
CONCLUSIONS: these results suggest that Copaifera langsdorffii Desf. oleoresin has antioxidant activity and may protect against oxidative stress in skin lesions of aloxan-induced diabetic rats.