Effect of antioxidants derived from Copaifera langsdorffii Desf. on skin tissue repair in diabetic rats.

OBJECTIVES

to assess the antioxidant effect of topically applied oleoresin from Copaifera langsdorffii Desf. on skin lesions in alloxan-induced diabetic rats.

METHODS

experiments were conducted on 200-300-gram adult male Wistar rats induced with diabetes by aloxan. A 7-millimeter metal punch was used for surgical circular epidermal excision. Animals were divided into five groups of five and treated with saline solution, mineral oil, 10% copaiba oil, essential fatty acids, or absolute copaiba oleoresin for one, seven, or 14 days. Malondialdehyde (MDA), nitrite, and glutathione (GSH) peroxidase concentrations were assessed to investigate oxidative activity progression. Tests were performed on animals approved by CEUA-URCA.

RESULTS

Copaifera langsdorffii Desf significantly reduced MDA and nitrite while increasing GSH. Groups treated with oleoresin, both 10% and absolute, improved assessed parameters.

CONCLUSIONS

these results suggest that Copaifera langsdorffii Desf. oleoresin has antioxidant activity and may protect against oxidative stress in skin lesions of aloxan-induced diabetic rats.